Benzohydroxamic acid

Product Name: Benzohydroxamic acid
CAS No.: 495-18-1
Chemical Name: Benzohydroxamic acid
Synonyms: BHAM;NSC 3136;NSC 147248;benzohydroxamate;Benzohydroxamsαure;N-HYDROXYBENZAMIDE;n-hydroxy-benzamid;BENZOHYROXAMICACID;benzohydroxamicaci;BENZHYDROXAMIC ACID
CBNumber: CB4764830
Molecular Formula: C7H7NO2
Formula Weight: 137.14
MOL File: 495-18-1.mol

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Benzohydroxamic acid Property

Melting point:: 126-130 °C(lit.)
Boiling point:: 251.96°C (rough estimate)
Density: 1.2528 (rough estimate)
refractive index: 1.5030 (estimate)
storage temp.: 2-8°C
solubility: Soluble in alcohol. Slightly soluble in ether. Insoluble in benzene.
pka: pK1: 8.89(0) (20°C)
form: Solid
color: Rhombic tablets
Water Solubility: 22 g/L (6 ºC)
BRN: 1907585
Stability:: Moisture and Temperature Sensitive
InChIKey: VDEUYMSGMPQMIK-UHFFFAOYSA-N
CAS DataBase Reference: 495-18-1(CAS DataBase Reference)
NIST Chemistry Reference: Benzamide, n-hydroxy-(495-18-1)
EPA Substance Registry System: Benzohydroxamic acid (495-18-1)

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Safety

Hazard Codes: Xn
Risk Statements: 68-40-20/21/22
Safety Statements: 45-36/37-36-22
WGK Germany: 3
RTECS: DF9650000
TSCA: Yes
HS Code: 29280090
Toxicity: LD orl-rat: >500 mg/kg NCNSA6 5,26,53

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 412260
Product name: Benzhydroxamic acid
Purity: 99%
Packaging: 5g
Price: $76.6
Updated: 2024/03/01

TCI Chemical

Product number: B0061
Product name: Benzohydroxamic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $36
Updated: 2024/03/01

TCI Chemical

Product number: B0061
Product name: Benzohydroxamic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $143
Updated: 2024/03/01

Alfa Aesar

Product number: A10509
Product name: Benzohydroxamic acid, 98%
Packaging: 10g
Price: $80.2
Updated: 2024/03/01

Alfa Aesar

Product number: A10509
Product name: Benzohydroxamic acid, 98%
Packaging: 25g
Price: $166
Updated: 2024/03/01

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Benzohydroxamic acid Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh3 and Bi(O(t)Bu)3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.

Uses

Benzhydroxamic acid may be employed for the Pd-catalyzed synthesis of benzisoxazolones.

Preparation

To a rapidly stirred suspension of 19.6 gm (0.35 mole) of powdered anhydrous potassium hydroxide in 120 ml of pyridine, maintained at 0-5°C, is a added a solution of 13.9 gm (0.2 mole) of hydroxylamine hydrochloride in 100 ml of pyridine.
While maintaining the reaction temperature at 0-5°C, 15 gm (0.1 mole) of ethyl benzoate is added. Vigorous stirring is continued at room temperature for 6 hr. Then the solids are filtered off. The solids are washed with cold water to remove inorganic coproducts. The remainder, recrystallized from aqueous ethanol, represents a 94% yield of potassium benzohydroxamate.
This salt is triturated with cold 0.01 TV hydrochloric acid. From this mixture, by the usual procedures, 12.5 gm (91% overall) of benzohydroxamic acid is isolated, m.p. 131°C (from aqueous alcohol).

Synthesis Reference(s)

Tetrahedron Letters, 33, p. 5055, 1992 DOI: 10.1016/S0040-4039(00)61187-5

General Description

Rhombic crystals or light beige solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Benzohydroxamic acid is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzohydroxamic acid emits toxic fumes of nitrogen oxides.

Fire Hazard

Flash point data for Benzohydroxamic acid are not available; however, Benzohydroxamic acid is probably combustible.

Safety Profile

Moderately toxic by ingestion.Mutation data reported. When heated to decomposition itemits toxic fumes of NOx.

Benzohydroxamic acid Preparation Products And Raw materials

Raw materials

Sodium chloride Ethyl acetate Hydrochloric acid Methanol Sodium hydroxide Hydroxylamine hydrochloride Hydroxylamine sulfate Methyl benzoate Ethyl benzoate

Preparation Products

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View Lastest Price from Benzohydroxamic acid manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Benzohydroxamic acid 495-18-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: Benzohydroxamic acid 495-18-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-09-13

Hebei Chuanghai Biotechnology Co,.LTD

Product: Benzohydroxamic acid 495-18-1
Price: US $5.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-12

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BENZHYDROXAMIC ACID

BENZOHYDROXAMIC ACID

N-HYDROXYBENZAMIDE

N-BENZOYLHYDROXYLAMINE

Benzamide,N-hydroxy-

benzohydroxamate

n-hydroxy-benzamid

Phenylhydroxamic acid

phenylhydroxamicacid

BENZOYL HYDROXIMIC ACID

Benzohydroxamsαure

Benzoylhydroxamic acid

benzoylhydroxamicacid

Hydroxylamine, N-benzoyl-

BenzohydroxamicAcid,>98%

Benzamide, N-hydroxy- (9CI)

Benzohydroxamicacid,99%

BENZOHYROXAMICACID

N-Benzoylhydroxylamine,Benzhydroxamicacid

BENZHYDROXAMIC ACID extrapure

BHAM

Benzeneformhydroxamic acid

Benzhydroxamic acid,N-Hydroxybenzamide

NSC 147248

NSC 3136

Benzhydroxamic acid 99%

Benzohydroxamic acid for synthesis

Benzohydroxamic Acid &gt

benzohydroxamicaci

Benzohydroxamic Acid extrapure, 99%

enzohydroxamic acid

Benzohydroxamic acid (6CI, 8CI)

BENZHYDROXAMIC ACID(BHA)

495-18-1

C7H7NO2

Hydroxylamines (N-Substituted)

Hydroxylamines

Organic Building Blocks

Nitrogen Compounds

C7

Carbonyl Compounds

Carboxylic Acids

Building Blocks

Aromatics

AMIDE

Hydroxylamines

Hydroxylamines (N-Substituted)

Inhibitors