Ozagrel hydrochloride
- Product Name
- Ozagrel hydrochloride
- CAS No.
- 78712-43-3
- Chemical Name
- Ozagrel hydrochloride
- Synonyms
- Vega;Ozag;Domenan;OKY-046 HCl;(e)-ohydrat;OZAGREL HCL;OzagrelHcl99%;oky046hydrochloride;Ozagrel Impurity 44;oky-046hydrochloride
- CBNumber
- CB4765488
- Molecular Formula
- C13H13ClN2O2
- Formula Weight
- 264.71
- MOL File
- 78712-43-3.mol
Ozagrel hydrochloride Property
- Melting point:
- 214-217°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- H2O: soluble
- form
- solid
- color
- white to off-white
- Water Solubility
- H2O: soluble
- Merck
- 14,6980
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
- CAS DataBase Reference
- 78712-43-3(CAS DataBase Reference)
Safety
- RIDADR
- 3077
- WGK Germany
- 2
- RTECS
- UD3380000
- HS Code
- 29332900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O1385
- Product name
- Ozagrel hydrochloride hydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $116
- Updated
- 2025/07/31
- Product number
- O1385
- Product name
- Ozagrel hydrochloride hydrate
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $354
- Updated
- 2022/05/15
- Product number
- O0419
- Product name
- Ozagrel Hydrochloride Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- O0419
- Product name
- Ozagrel Hydrochloride Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- 1510
- Product name
- Ozagrelhydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $104
- Updated
- 2021/12/16
Ozagrel hydrochloride Chemical Properties,Usage,Production
Description
Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane A2 (TXA2) synthetase (IC50 = 4 nM). It does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase, or PGE2 isomerase (IC50 > 1 mM)[1]. Ozagrel HCl inhibits platelet aggregation in vitro[2] and arachidonate-induced arterial contraction in vivo. It protects against arachidonate-induced sudden death in rabbits[3] and alleviates liver injury induced by acetaminophen overdose in mice[4].
History
Ozagrel hydrochloride was initially developed jointly by Ono Pharmaceutical Co., Ltd. and Kissei Pharmaceutical Co., Ltd. in Japan. Approved for marketing in Japan in 1988, it became the world's first commercially available potent thromboxane A2 (TXA2) synthase inhibitor. This medication is primarily indicated for the treatment of patients with ischaemic cerebrovascular disease, as it exhibits dual effects of inhibiting platelet aggregation and dilating blood vessels, thereby effectively preventing thrombus formation.
Uses
Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice.
Definition
ChEBI: Ozagrel hydrochloride is an organic molecular entity.
IC 50
TXA2/TP
References
[1] SEIJI HIRAKU . Pharmacological Studies on the TXA2 Synthetase Inhibitor (E)-3-[p(1H-lmidazol-1-Ylmethyl)Phenyl]-2-Propenoic Acid (OKY-046)[J]. Japanese journal of pharmacology, 1986, 41 3: Pages 393-401. DOI:10.1254/jjp.41.393
[2] JUN NAITO . Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets[J]. European journal of pharmacology, 1983, 91 1: Pages 41-48. DOI:10.1016/0014-2999(83)90359-x
[3] LEE C. EDMONDS Allan M L. Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death[J]. Life sciences, 1984, 35 17: Pages 1763-1768. DOI:10.1016/0024-3205(84)90273-x
[4] YOSHIRO TOMISHIMA. Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.[J]. BMC Gastroenterology, 2013, 13: 21. DOI:10.1186/1471-230x-13-21
Ozagrel hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ozagrel hydrochloride Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
- Tel
- --
- Fax
- --
- export@ecochem.dk
- Country
- Europe
- ProdList
- 6371
- Advantage
- 66
- Tel
- --
- Fax
- --
- Sales@kemikalieimport.dk
- Country
- Europe
- ProdList
- 6685
- Advantage
- 47
View Lastest Price from Ozagrel hydrochloride manufacturers
- Product
- Ozagrel hydrochloride 78712-43-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Ozagrel hydrochloride 78712-43-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-19