5-Chloro-1H-pyrazolo[4,3-b]pyridine

Product Name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
CAS No.: 94220-45-8
Chemical Name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
Synonyms: 5-chloro-1H-pyrazolo[4;5-Chloro-1H-pyrazolo[4,3-...;5-chloro-2H-pyrazolo[4,3-b]pyridine;5-CHLORO-1H-PYRAZOLO[4,3-B]PYRIDINE;1H-Pyrazolo[4,3-b]pyridine,5-chloro-;5-Chloro-1H-pyrazolo[4,3-b]pyridine
CBNumber: CB4770800
Molecular Formula: C6H4ClN3
Formula Weight: 153.57
MOL File: 94220-45-8.mol

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5-Chloro-1H-pyrazolo[4,3-b]pyridine Property

Boiling point:: 323.8±22.0 °C(Predicted)
Density: 1.531±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 9.74±0.40(Predicted)
Appearance: Off-white to light yellow Solid
InChIKey: PYZUYYOYVZFJGX-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BLN00012
Product name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
Purity: Aldrich
Packaging: 1g
Price: $783
Updated: 2025/07/31

TRC

Product number: C380685
Product name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
Packaging: 250mg
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 073018
Product name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
Purity: 95+%
Packaging: 5g
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: W9664
Product name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
Packaging: 5g
Price: $178
Updated: 2021/12/16

ChemScene

Product number: CS-D0857
Product name: 5-Chloro-1H-pyrazolo[4,3-b]pyridine
Purity: 98.21%
Packaging: 5g
Price: $88
Updated: 2021/12/16

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5-Chloro-1H-pyrazolo[4,3-b]pyridine Chemical Properties,Usage,Production

Uses

5-Chloro-1H-pyrazolo[4,3-b]pyridine is an intermediate used to prepare 2-aryl or heteroaryl indole derivatives as ASIC channel modulators for treating pain, bone diseases, and other disorders.

Synthesis

164666-68-6

94220-45-8

6-Chloro-2-methylpyridin-3-amine (12.8 g, 0.09 mol) was used as starting material and dissolved in chloroform (500 mL). Acetic anhydride (34.0 mL, 0.36 mol) and potassium acetate (10.6 g, 0.11 mol) were added sequentially, and the reaction mixture was stirred and reacted at 60 °C for 2 hours. Subsequently, isoamyl nitrite (27.8 mL, 0.21 mol) and 1,4,7,10,13,16-hexaoxacyclooctadecane (2.4 g, 8.90 mmol) were added to the reaction system, and the reaction continued to be stirred at 60 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting crude product was dissolved in a solvent mixture of methanol (225 mL) and water (50 mL), cooled to 0 °C and potassium carbonate (45 g) was added in batches. The mixture was stirred at 0 °C for 10 min, then brought to room temperature and continued stirring for 3 h. The mixture was then cooled to room temperature and stirred for 3 h. The reaction solution was then mixed with potassium carbonate. Water was added to the reaction solution and stirred at room temperature for 1 h. The precipitate was collected and washed with cold water and hexane. The resulting solid was dried in a vacuum oven at 50 °C overnight to afford the target product 5-chloro-1H-pyrazolo[3,4-b]pyridine (13.6 g, 97% yield) as a white solid.LRMS (m/z): 154,156 ([M+H]+, [M+3]+).1H-NMR (300 MHz, CDCl3)δ: 7.35 (d, 1H), 7.84 (dd, 1H), 8.26 (d, 1H), 10.39 (s, 1H).

References

[1] Patent: WO2017/220431, 2017, A1. Location in patent: Page/Page column 35
[2] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0745; 0747-0749

5-Chloro-1H-pyrazolo[4,3-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Chloro-1H-pyrazolo[4,3-b]pyridine Suppliers

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View Lastest Price from 5-Chloro-1H-pyrazolo[4,3-b]pyridine manufacturers

Career Henan Chemical Co

Product: 5-Chloro-1H-pyrazolo[4,3-b]pyridine 94220-45-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-07

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Heterocycle-Pyridine series