2-Bromo-3-fluoroaniline

Product Name: 2-Bromo-3-fluoroaniline
CAS No.: 111721-75-6
Chemical Name: 2-Bromo-3-fluoroaniline
Synonyms: 2-BROMO-3-FLUORO-PHENYLAMINE;Bromo-3-fluoroaniline;2-BROMO-3-FLUOROANILINE;2-Bromo-3-fluoroaniline 98%;Benzenamine, 2-bromo-3-fluoro-;2-Bromo-3-fluoroaniline, 97%, for synthesis;2-Bromo-3-fluoroaniline ISO 9001：2015 REACH;2-Bromo-3-fluorophenylamine,2-Bromo-3-fluoroaniline
CBNumber: CB4777632
Molecular Formula: C6H5BrFN
Formula Weight: 190.01
MOL File: 111721-75-6.mol

More

Less

2-Bromo-3-fluoroaniline Property

Melting point:: 32-34 °C
Boiling point:: 229.8±20.0 °C(Predicted)
Density: 1.670
Flash point:: 94°(201°F)
refractive index: 1.5830
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Crystalline
pka: 1.52±0.10(Predicted)
color: Off-white
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C6H5BrFN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2
InChIKey: XZRSXRUYZXBTGD-UHFFFAOYSA-N
SMILES: C1(N)=CC=CC(F)=C1Br
CAS DataBase Reference: 111721-75-6(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36-36/37/38-20/21/22
Safety Statements: 9-26-36/37-60
RIDADR: 2811
Hazard Note: Harmful/Irritant
HazardClass: 6.1
HS Code: 29214200

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B961495
Product name: 2-Bromo-3-fluoroaniline
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B961495
Product name: 2-Bromo-3-fluoroaniline
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: PC5082
Product name: 2-Bromo-3-fluoroaniline
Purity: 98%
Packaging: 1g
Price: $32
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-B-23
Product name: 2-Bromo-3-fluoroaniline
Purity: 98%
Packaging: 1g
Price: $37
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB67928
Product name: 2-Bromo-3-fluoroaniline
Packaging: 10g
Price: $75
Updated: 2021/12/16

More

Less

2-Bromo-3-fluoroaniline Chemical Properties,Usage,Production

Chemical Properties

Light yellow liquid

Uses

2-Bromo-3-fluoroaniline is used as pharmaceutical intermediate.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 2151, 1990 DOI: 10.1002/jhet.5570270755

Synthesis

59255-94-6

111721-75-6

General procedure for the synthesis of 2-bromo-3-fluoroaniline from 2-bromo-3-fluoro nitrobenzene: 2-bromo-1-fluoro-3-nitrobenzene (1.0 g, 5.0 mmol) was dissolved in methanol (50 mL) at 0 °C, and NiCl? (2.2 g, 10 mmol) and NaBH? (0.50 g, 14 mmol) were added sequentially. After the addition was completed, the reaction mixture was stirred at 0 °C for 5 min. Subsequently, the reaction was quenched by the addition of water (20 mL) and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried over anhydrous Na?SO? and concentrated under reduced pressure to afford 2-bromo-3-fluoroaniline (600 mg, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl?): δ 7.07-7.02 (m, 1H), 6.55-6.49 (m, 1H), 4.22 (br s, 2H).

References

[1] Patent: CN108002976, 2018, A. Location in patent: Paragraph 0045; 0047; 0050; 0051; 0060; 0069
[2] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437
[3] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 121
[4] Patent: US2011/98311, 2011, A1
[5] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1674

2-Bromo-3-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-Bromo-3-fluoroaniline Suppliers

China 192 Germany 2 India 4 Italy 1 United Kingdom 10 United States 20 Global 229

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Aceschem Inc.

Tel: +1-817863-6948 +1-（817）863-6948
Email: sales@aceschem.com
Country: United States
ProdList: 19632
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

Anthem Pharmaceutical Research LLC

Tel: --
Fax: --
Email: sales@anthempharma.com
Country: United States
ProdList: 3040
Advantage: 30

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

AstaTech, Inc

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 6371
Advantage: 58

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

Asymchem Laboratories, Inc.

Tel: --
Fax: --
Email: info@asymchem.com
Country: United States
ProdList: 1315
Advantage: 69

AcceleDev Chemical LLC

Tel: --
Fax: --
Email: info@acceledev.com
Country: United States
ProdList: 632
Advantage: 42

More

Less

View Lastest Price from 2-Bromo-3-fluoroaniline manufacturers

Career Henan Chemical Co

Product: 2-Bromo-3-fluoroaniline 111721-75-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-08

111721-75-6, 2-Bromo-3-fluoroanilineRelated Search:

Ethyl bromodifluoroacetate 3-Fluoroaniline 2-Fluoroaniline 4-Bromoaniline 4-Fluoroaniline 2-Bromoaniline 2,4,5-Trifluoroaniline 4-(Trifluoromethoxy)aniline BROMOTRIFLUOROMETHANE 2-Bromo-3-fluoronitrobenzene 2,4,5-TRIFLUORO-6-BROMOANILINE 2-Bromo-4,5-difluoronitrobenzene Bromine 2-Bromo-5-fluoroaniline98%,2-BROMO-5-FLUOROANILINE,2-Bromo-5-fluoroaniline 98% 4-Fluorobenzoyl chloride 3-Bromo-4-fluoroaniline98%,3-BROMO-4-FLUOROANILINE,3-Bromo-4-fluoroaniline 98% 3-CHLORO-2,6-DIBROMO-4-FLUOROANILINE 2,4-DIBROMO-6-FLUOROANILINE

2-BROMO-3-FLUOROANILINE

2-BROMO-3-FLUORO-PHENYLAMINE

2-Bromo-3-fluoroaniline 98%

Bromo-3-fluoroaniline

2-Bromo-3-fluoroaniline, 97%, for synthesis

Benzenamine, 2-bromo-3-fluoro-

2-Bromo-3-fluoroaniline ISO 9001：2015 REACH

2-Bromo-3-fluorophenylamine,2-Bromo-3-fluoroaniline

111721-75-6

11721-75-6

Fluorine series

Pyridines

Aniline

Anilines, Aromatic Amines and Nitro Compounds