3-Chloro-4-methylpyridazine
- Product Name
- 3-Chloro-4-methylpyridazine
- CAS No.
- 68206-04-2
- Chemical Name
- 3-Chloro-4-methylpyridazine
- Synonyms
- 3-CHLORO-4-METHYLPYRIDAZINE;3-Chloro-4-methyl-1,2-diazine;Pyridazine, 3-chloro-4-methyl-;3-Chloro-4-methylpyridazine97%;3-Chloro-4-methylpyridazine 97%;3-Chloro-4-methylpyridazine ISO 9001：2015 REACH
- CBNumber
- CB4848477
- Molecular Formula
- C5H5ClN2
- Formula Weight
- 128.56
- MOL File
- 68206-04-2.mol
3-Chloro-4-methylpyridazine Property
- Melting point:
- 46-47 °C
- Boiling point:
- 254.7±20.0 °C(Predicted)
- Density
- 1.234±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 1.54±0.10(Predicted)
- color
- White
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C370916
- Product name
- 3-Chloro-4-methylpyridazine
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC151278
- Product name
- 3-Chloro-4-methylpyridazine
- Packaging
- 500mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 083991
- Product name
- 3-Chloro-4-methylpyridazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 3H32-5-84
- Product name
- 3-Chloro-4-methylpyridazine
- Purity
- 95%
- Packaging
- 1g
- Price
- $264
- Updated
- 2021/12/16
- Product number
- FC151278
- Product name
- 3-Chloro-4-methylpyridazine
- Packaging
- 1g
- Price
- $359
- Updated
- 2021/12/16
3-Chloro-4-methylpyridazine Chemical Properties,Usage,Production
Uses
3-Chloro-4-methylpyridazine is a useful intermediate for the synthesis of pesticides and anti-viral drugs.
Synthesis
33471-40-8
68206-04-2
General procedure for the synthesis of 3-chloro-4-methylpyridazine from 4-methyl-3(2H)-pyridazinone: The product of step c) (12.2 g, 0.112 mol) was dissolved in phosphorochloridic acid chloride (125 mL) and heated to reflux for 3 hours at 90 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and concentrated to near dryness under reduced pressure. The concentrated residue was carefully poured into an ice/water mixture and the pH was adjusted to basic by slowly adding 4N NaOH solution. Subsequently, extraction was carried out with ether and the aqueous phase was then subjected to a secondary extraction with dichloromethane (DCM). All organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure. Finally, the residue was purified by rapid chromatography on silica gel with 2:1 ethyl acetate-isohexane as eluent to give an orange solid product (11.2 g, 78% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.97 (1H, d, J = 4.9 Hz), 7.35 (1H, d, J = 4.9 Hz), 2.44 (3H, s) ppm.
References
[1] Patent: WO2004/74290, 2004, A1. Location in patent: Page 79
[2] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 239 - 249
3-Chloro-4-methylpyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloro-4-methylpyridazine manufacturers
- Product
- 3-Chloro-4-methylpyridazine 68206-04-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
- Product
- 3-Chloro-4-methylpyridazine 68206-04-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19