ChemicalBook > CAS DataBase List > 3-Chloro-4-methylpyridazine

3-Chloro-4-methylpyridazine

Product Name
3-Chloro-4-methylpyridazine
CAS No.
68206-04-2
Chemical Name
3-Chloro-4-methylpyridazine
Synonyms
3-CHLORO-4-METHYLPYRIDAZINE;3-Chloro-4-methyl-1,2-diazine;Pyridazine, 3-chloro-4-methyl-;3-Chloro-4-methylpyridazine97%;3-Chloro-4-methylpyridazine 97%;3-Chloro-4-methylpyridazine ISO 9001：2015 REACH
CBNumber
CB4848477
Molecular Formula
C5H5ClN2
Formula Weight
128.56
MOL File
68206-04-2.mol
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3-Chloro-4-methylpyridazine Property

Melting point:
46-47 °C
Boiling point:
254.7±20.0 °C(Predicted)
Density 
1.234±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
1.54±0.10(Predicted)
color 
White
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C370916
Product name
3-Chloro-4-methylpyridazine
Packaging
1g
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151278
Product name
3-Chloro-4-methylpyridazine
Packaging
500mg
Price
$205
Updated
2021/12/16
Matrix Scientific
Product number
083991
Product name
3-Chloro-4-methylpyridazine
Purity
97%
Packaging
1g
Price
$218
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-84
Product name
3-Chloro-4-methylpyridazine
Purity
95%
Packaging
1g
Price
$264
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC151278
Product name
3-Chloro-4-methylpyridazine
Packaging
1g
Price
$359
Updated
2021/12/16
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3-Chloro-4-methylpyridazine Chemical Properties,Usage,Production

Uses

3-Chloro-4-methylpyridazine is a useful intermediate for the synthesis of pesticides and anti-viral drugs.

Synthesis

33471-40-8

68206-04-2

General procedure for the synthesis of 3-chloro-4-methylpyridazine from 4-methyl-3(2H)-pyridazinone: The product of step c) (12.2 g, 0.112 mol) was dissolved in phosphorochloridic acid chloride (125 mL) and heated to reflux for 3 hours at 90 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and concentrated to near dryness under reduced pressure. The concentrated residue was carefully poured into an ice/water mixture and the pH was adjusted to basic by slowly adding 4N NaOH solution. Subsequently, extraction was carried out with ether and the aqueous phase was then subjected to a secondary extraction with dichloromethane (DCM). All organic phases were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure. Finally, the residue was purified by rapid chromatography on silica gel with 2:1 ethyl acetate-isohexane as eluent to give an orange solid product (11.2 g, 78% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.97 (1H, d, J = 4.9 Hz), 7.35 (1H, d, J = 4.9 Hz), 2.44 (3H, s) ppm.

References

[1] Patent: WO2004/74290, 2004, A1. Location in patent: Page 79
[2] Pharmaceutical Bulletin, 1957, vol. 5, p. 229,233
[3] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 239 - 249

3-Chloro-4-methylpyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-methylpyridazine Suppliers

China 108 Germany 1 India 1 Switzerland 1 United Kingdom 4 United States 15 Global 130
Accela ChemBio Inc.
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+1-858-6993322
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(+1)-858-876-1948
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United States
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Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
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Synthonix Inc
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Alfa Chemistry
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Combi-Blocks Inc.
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SynQuest Laboratories, Inc.
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Matrix Scientific
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Labseeker Inc
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Small Molecules, Inc.
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Frontier Scientific, Inc.
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Waterstone Technology, LLC
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Small Molecules, Inc.
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Atlantic SciTech Group, Inc.
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View Lastest Price from 3-Chloro-4-methylpyridazine manufacturers

Dideu Industries Group Limited
Product
3-Chloro-4-methylpyridazine 68206-04-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-02
Career Henan Chemical Co
Product
3-Chloro-4-methylpyridazine 68206-04-2
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500kg
Release date
2018-08-19

68206-04-2, 3-Chloro-4-methylpyridazineRelated Search:

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