Description Reference
ChemicalBook > CAS DataBase List > 4-Fluorobenzoic acid

4-Fluorobenzoic acid

Description Reference
Product Name
4-Fluorobenzoic acid
CAS No.
456-22-4
Chemical Name
4-Fluorobenzoic acid
Synonyms
PFBA;P-FLUOROBENZOIC ACID;potassium 2,2,3,3,3-pentafluoropropanoate;4-fluoro-benzoicaci;The acid;AKOS 92636;p-Fluorobenzoic;fluorobenzoicacid;Fluoro benzoic ac;4-Fluorbenzoesure
CBNumber
CB4853637
Molecular Formula
C7H5FO2
Formula Weight
140.11
MOL File
456-22-4.mol
More
Less

4-Fluorobenzoic acid Property

Melting point:
182-184 °C (lit.)
Boiling point:
117 °C
Density 
1.479
storage temp. 
Sealed in dry,Room Temperature
solubility 
alcohol: soluble
form 
Crystalline Powder
pka
4.15(at 25℃)
color 
White to slightly yellow
Water Solubility 
Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water.
Merck 
14,4171
BRN 
1906922
InChIKey
BBYDXOIZLAWGSL-UHFFFAOYSA-N
CAS DataBase Reference
456-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 4-fluoro-(456-22-4)
EPA Substance Registry System
Benzoic acid, 4-fluoro- (456-22-4)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-41-36/37/38
Safety Statements 
26-39-24/25-22-37/39-36
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29163900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
128384
Product name
4-Fluorobenzoic acid
Purity
98%
Packaging
5g
Price
$17.8
Updated
2024/03/01
Sigma-Aldrich
Product number
128384
Product name
4-Fluorobenzoic acid
Purity
98%
Packaging
25g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
F0112
Product name
4-Fluorobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$47
Updated
2024/03/01
Alfa Aesar
Product number
A14129
Product name
4-Fluorobenzoic acid, 98%
Packaging
25g
Price
$34.4
Updated
2024/03/01
Alfa Aesar
Product number
A14129
Product name
4-Fluorobenzoic acid, 98%
Packaging
100g
Price
$77.65
Updated
2024/03/01
More
Less

4-Fluorobenzoic acid Chemical Properties,Usage,Production

Description

4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the 18F labeling of antibodies. It has been used in high resolution charge density study.

Reference

AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorobenzoic acid has been used in high resolution charge density study.

Definition

ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4.

Purification Methods

Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.]

4-Fluorobenzoic acid Preparation Products And Raw materials

Raw materials

Benzocaine Ethyl 4-fluorobenzoate 4-Fluorobenzaldehyde Fluoroboric acid STANDARD BUFFER

Preparation Products

Lomefloxacin 4-Fluorobenzoyl chloride (4-(4-[BIS(4-FLUOROPHENYL)METHYL]PIPERAZIN-1-YL)PHENYL)METHANOL
More
Less

4-Fluorobenzoic acid Suppliers

Americas 1 Australia 1 Belgium 1 Canada 3 China 479 Europe 3 France 1 Germany 9 India 23 Italy 1 Japan 5 Slovakia 1 Switzerland 2 Ukraine 2 United Kingdom 15 United States 42 Global 589
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Standard Reference Materials Group
Tel
--
Fax
--
Email
srminfo@nist.gov
Country
United States
ProdList
1045
Advantage
0
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AnsisChem
Tel
--
Fax
--
Country
United States
ProdList
409
Advantage
38
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Chemiplus Corporation
Tel
--
Fax
--
Email
okazaki@chemiplus.com
Country
United States
ProdList
3198
Advantage
38
M/S PANAMIT INTERNATIONAL
Tel
--
Fax
--
Email
sales@jyotichem.com
Country
United States
ProdList
312
Advantage
46
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Aakash Chemicals and Dye-Stuffs, Inc.
Tel
--
Fax
--
Email
info@aakashchemicals.com
Country
United States
ProdList
1012
Advantage
54
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
Honeywell Specialty Chemicals Seelze GmbH
Tel
--
Fax
--
Email
ofc@honeywell.com
Country
United States
ProdList
639
Advantage
87
Frinton Laboratories, Inc.
Tel
--
Fax
--
Email
sales@frinton.com
Country
United States
ProdList
1459
Advantage
61
Marshallton Research Laboratories Inc.
Tel
--
Fax
--
Email
marshallton@windstream.net
Country
United States
ProdList
513
Advantage
59
Eastern Chemical Corp.
Tel
--
Fax
--
Email
eastern@u-g.com
Country
United States
ProdList
2786
Advantage
34
Davos Chemical Corporation
Tel
--
Fax
--
Email
info@davos.com
Country
United States
ProdList
1640
Advantage
65
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
Narchem Corporation
Tel
--
Fax
--
Email
sales@narchem.com
Country
United States
ProdList
2813
Advantage
60
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
More
Less

View Lastest Price from 4-Fluorobenzoic acid manufacturers

Speranza Chemical Co., Ltd.
Product
4-Fluorobenzoic acid 456-22-4
Price
US $15.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300MT/year
Release date
2019-12-24
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
4-Fluorobenzoic acid 456-22-4
Price
US $40.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-30
Shanghai UCHEM Inc.
Product
4-Fluorobenzoic acid 456-22-4
Price
US $38.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100kg
Release date
2023-10-30

456-22-4, 4-Fluorobenzoic acidRelated Search:

4-Fluorobenzonitrile Stearic acid 4-Bromofluorobenzene Folic acid 4-Fluorobenzamide 4-Fluorobenzaldehyde 4-Fluoroanisole Florfenicol 4-(4-Fluorobenzoyl)butyric acid Methyl 4-fluorobenzoate 2,6-Difluorobenzoic acid Ethyl 4-fluorobenzoate Transfluthrin Ethyl 2-(Chlorosulfonyl)acetate 2,4,5-Trifluorobenzoic acid Citric acid 4-Fluorobenzyl alcohol Ascoric Acid

  • 4-FLUOROBENZOIC ACID
  • AKOS 92636
  • 4-fluoro-benzoicaci
  • Benzoic acid, p-fluoro-
  • Benzoicacid,4-fluoro-
  • fluorobenzoicacid
  • para-Fluorobenzoic acid
  • p-Fluorobenzoic Acid 4-Fluorobenzoic Acid
  • 4-Fluorobenzoi acid
  • 4-FLUOROBENZOIC ACID, SUBLIMED, 99%
  • 4-FLUOROBENZOIC ACID, FOR ELEMENTAL ANALYSIS
  • P-FLUOROBENZOIC ACID GRADE I
  • 4-Fluorobenzoicacid,98%
  • PFBA
  • P-FLUOROBENZOIC ACID
  • TIMTEC-BB SBB008568
  • RARECHEM AL BO 0053
  • potassium 2,2,3,3,3-pentafluoropropanoate
  • p-Fluorobenzoic
  • p-Fluorobenzoicacid,min.97%
  • 4-Fluorobenzoic acid ,99%
  • p-Fluorobenzoic acid, min. 97%
  • 4-Fluorobenzoic acid, 99% 25GR
  • 4-FLUOROBENZOIC ACID FOR SYNTHESIS
  • Fluoro benzoic ac
  • The acid
  • 4-Fluorobenzoic acid 99%, purified by sublimation
  • Haloperidol Impurity 14
  • 4-FluorobenzoicAcid&gt
  • 4-Fluorbenzoesure
  • 4-Fluorobenzoic Acid pure, 98%
  • 456-22-4
  • FC6H4COOH
  • Organic Building Blocks
  • C7
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • CARBOXYLIC ACID
  • carboxylic acid| alkyl Fluorine
  • Carboxylic Acids
  • Phenyls & Phenyl-Het
  • C7
  • Carbonyl Compounds
  • Benzene derivatives
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Carboxylic Acids
  • Phenyls & Phenyl-Het
  • Fluorobenzene
  • API intermediates
  • Fluorin-contained Benzoic acid series
  • bc0001