ChemicalBook > CAS DataBase List > 2-Bromo-5-trifluoromethylphenol
2-Bromo-5-trifluoromethylphenol
- Product Name
- 2-Bromo-5-trifluoromethylphenol
- CAS No.
- 402-05-1
- Chemical Name
- 2-Bromo-5-trifluoromethylphenol
- Synonyms
- 2-Bromo-5-trifluoromethylphenol;5-BROMO-3-TRIFLUOROMETHYLPHENOL;5-Bromo-2-Trifluoromethyl-Phenol;2-Bromo-3-(trifluoromethyl)phenol;Phenol, 2-bromo-5-(trifluoromethyl)-;5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)
- CBNumber
- CB4855015
- Molecular Formula
- C7H4BrF3O
- Formula Weight
- 241.01
- MOL File
- 402-05-1.mol
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2-Bromo-5-trifluoromethylphenol Property
- Melting point:
- 22-23°
- Boiling point:
- 56.0-57.5 °C(Press: 3.5-4.0 Torr)
- Density
- 1.752
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Liquid
- pka
- 7.43±0.10(Predicted)
- color
- Pale brown
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Safety
- RIDADR
- UN1760
- HazardClass
- IRRITANT
- HazardClass
- 8
- HS Code
- 2905599890
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H332Harmful if inhaled
- Precautionary statements
-
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- B695955
- Product name
- 2-Bromo-5-trifluoromethylphenol
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
TRC
- Product number
- B695955
- Product name
- 2-Bromo-5-trifluoromethylphenol
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 059835
- Product name
- 2-Bromo-5-(trifluoromethyl)phenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 059835
- Product name
- 2-Bromo-5-(trifluoromethyl)phenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $35
- Updated
- 2021/12/16
AK Scientific
- Product number
- U577
- Product name
- 2-Bromo-5-(trifluoromethyl)phenol
- Packaging
- 5g
- Price
- $77
- Updated
- 2021/12/16
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2-Bromo-5-trifluoromethylphenol Chemical Properties,Usage,Production
Chemical Properties
light brown liquid
Uses
2-Bromo-3-(trifluoromethyl)phenol is used as a reactant in the synthesis of benzimidazolone and benzothiazolone compounds as AMPA receptor modulators.
Synthesis
98-17-9
402-05-1
General procedure for the synthesis of 2-bromo-5-trifluoromethylphenol from 3-trifluoromethylphenol: To a stirred solution of 61.65 g (0.38 mol) of 3-trifluoromethylphenol dissolved in 240 ml of carbon disulfide, 19.6 ml (0.38 mol) of bromine was slowly added dropwise. The reaction mixture was stirred continuously at room temperature for about 18 hours. Subsequently, the reaction solution was partitioned between 200 ml of dichloromethane and 100 ml of water. The organic phase was separated, washed with 20 mL of saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane containing 40% hexane as eluent. The eluate containing the target product was collected and concentrated under reduced pressure to give 48.8 g (53% yield) of 2-bromo-5-trifluoromethylphenol as a yellow oil. Ion spray mass spectrometry (MS) analysis showed m/e = 239,241 (M + 1).
References
[1] Journal of the American Chemical Society, 1951, vol. 73, p. 1325
[2] Journal of Organic Chemistry, 1951, vol. 16, p. 586,606
[3] Patent: US6638936, 2003, B1
2-Bromo-5-trifluoromethylphenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-5-trifluoromethylphenol manufacturers
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
- Product
- 2-Bromo-5-trifluoromethylphenol 402-05-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2023-03-04
Career Henan Chemical Co
- Product
- 2-Bromo-5-trifluoromethylphenol 402-05-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30
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