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2-Bromo-5-trifluoromethylphenol

Product Name
2-Bromo-5-trifluoromethylphenol
CAS No.
402-05-1
Chemical Name
2-Bromo-5-trifluoromethylphenol
Synonyms
2-Bromo-5-trifluoromethylphenol;5-BROMO-3-TRIFLUOROMETHYLPHENOL;5-Bromo-2-Trifluoromethyl-Phenol;2-Bromo-3-(trifluoromethyl)phenol;Phenol, 2-bromo-5-(trifluoromethyl)-;5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)
CBNumber
CB4855015
Molecular Formula
C7H4BrF3O
Formula Weight
241.01
MOL File
402-05-1.mol
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2-Bromo-5-trifluoromethylphenol Property

Melting point:
22-23°
Boiling point:
56.0-57.5 °C(Press: 3.5-4.0 Torr)
Density 
1.752
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
pka
7.43±0.10(Predicted)
color 
Pale brown
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Safety

RIDADR 
UN1760
HazardClass 
IRRITANT
HazardClass 
8
HS Code 
2905599890
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H332Harmful if inhaled

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B695955
Product name
2-Bromo-5-trifluoromethylphenol
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
B695955
Product name
2-Bromo-5-trifluoromethylphenol
Packaging
250mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64425
Product name
2-Bromo-5-(trifluoromethyl)phenol
Packaging
5G
Price
$200
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0353134
Product name
2-BROMO-5-TRIFLUOROMETHYLPHENOL
Purity
95.00%
Packaging
5MG
Price
$495.19
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB64425
Product name
2-Bromo-5-(trifluoromethyl)phenol
Packaging
25g
Price
$500
Updated
2021/12/16
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2-Bromo-5-trifluoromethylphenol Chemical Properties,Usage,Production

Chemical Properties

light brown liquid

Uses

2-Bromo-3-(trifluoromethyl)phenol is used as a reactant in the synthesis of benzimidazolone and benzothiazolone compounds as AMPA receptor modulators.

Synthesis

98-17-9

402-05-1

General procedure for the synthesis of 2-bromo-5-trifluoromethylphenol from 3-trifluoromethylphenol: To a stirred solution of 61.65 g (0.38 mol) of 3-trifluoromethylphenol dissolved in 240 ml of carbon disulfide, 19.6 ml (0.38 mol) of bromine was slowly added dropwise. The reaction mixture was stirred continuously at room temperature for about 18 hours. Subsequently, the reaction solution was partitioned between 200 ml of dichloromethane and 100 ml of water. The organic phase was separated, washed with 20 mL of saturated aqueous sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane containing 40% hexane as eluent. The eluate containing the target product was collected and concentrated under reduced pressure to give 48.8 g (53% yield) of 2-bromo-5-trifluoromethylphenol as a yellow oil. Ion spray mass spectrometry (MS) analysis showed m/e = 239,241 (M + 1).

References

[1] Journal of the American Chemical Society, 1951, vol. 73, p. 1325
[2] Journal of Organic Chemistry, 1951, vol. 16, p. 586,606
[3] Patent: US6638936, 2003, B1

2-Bromo-5-trifluoromethylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-trifluoromethylphenol Suppliers

China 116 Germany 1 India 3 United Kingdom 2 United States 15 Global 137
Insight Chemical Solutions Limited
Tel
--
Fax
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Country
Germany
ProdList
235
Advantage
46
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View Lastest Price from 2-Bromo-5-trifluoromethylphenol manufacturers

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Product
2-Bromo-5-trifluoromethylphenol 402-05-1
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
98%
Supply Ability
100kg
Release date
2023-03-04
Career Henan Chemical Co
Product
2-Bromo-5-trifluoromethylphenol 402-05-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-30

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  • 2-Bromo-5-trifluoromethylphenol
  • 2-Bromo-3-(trifluoromethyl)phenol
  • 5-Bromo-2-Trifluoromethyl-Phenol
  • 5-BROMO-3-TRIFLUOROMETHYLPHENOL
  • 5-BROMO-2-TRIFLUOROMETHYLPHENOL,SPECIFICATION: >99.0%(GC FID)
  • Phenol, 2-bromo-5-(trifluoromethyl)-
  • 402-05-1
  • C7H4OBrF3
  • Fluorine series