4-Chloro-1-butanol

Product Name: 4-Chloro-1-butanol
CAS No.: 928-51-8
Chemical Name: 4-Chloro-1-butanol
Synonyms: 4-chlorobutan-1-ol;4-CHLOROBUTANOL;oro-1-butanoL;4-Chlorolbutanol;4-Choro-1-bytanol;4-CHLOROBUTANOL-1;4-chloro-1-butano;4-Chlorbutan-1-ol;4-CHLORO-1-BUTANOL;4-ChIoro-1-butanoI
CBNumber: CB5100347
Molecular Formula: C4H9ClO
Formula Weight: 108.57
MOL File: 928-51-8.mol

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4-Chloro-1-butanol Property

Boiling point:: 84-85 °C/16 mmHg (lit.)
Density: 1.088 g/mL at 25 °C (lit.)
refractive index: n20/D 1.453(lit.)
Flash point:: 97 °F
storage temp.: 2-8°C
solubility: Soluble in methanol, chloroform, and dimethyl sufoxide.
form: Liquid
pka: 15.01±0.10(Predicted)
color: Clear colorless to light yellow
BRN: 1731408
InChIKey: HXHGULXINZUGJX-UHFFFAOYSA-N
CAS DataBase Reference: 928-51-8(CAS DataBase Reference)
NIST Chemistry Reference: 4-Chloro-1-butanol(928-51-8)
EPA Substance Registry System: 1-Butanol, 4-chloro- (928-51-8)

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Safety

Hazard Codes: Xn,C,F
Risk Statements: 10-22-36/37/38-20/21/22-34-40
Safety Statements: 23-24/25-36/37/39-26-16-36/37
RIDADR: UN 2920 8/PG 2
WGK Germany: 3
RTECS: EL1325000
Hazard Note: Harmful
TSCA: Yes
HazardClass: 3.2
PackingGroup: III
HS Code: 29055910

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 278823
Product name: 4-Chloro-1-butanol
Purity: technical grade, ~85%
Packaging: 50ml
Price: $120
Updated: 2024/03/01

Sigma-Aldrich

Product number: 278823
Product name: 4-Chloro-1-butanol
Purity: technical grade, ~85%
Packaging: 250ml
Price: $309.6
Updated: 2024/03/01

TCI Chemical

Product number: C0144
Product name: 4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran)
Purity: >85.0%(GC)
Packaging: 25g
Price: $58
Updated: 2024/03/01

TCI Chemical

Product number: C0144
Product name: 4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran)
Purity: >85.0%(GC)
Packaging: 500g
Price: $435
Updated: 2024/03/01

Alfa Aesar

Product number: L04042
Product name: 4-Chloro-1-butanol, tech. 85%
Packaging: 50g
Price: $72.8
Updated: 2024/03/01

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4-Chloro-1-butanol Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Tetramethylene chlorohydrin is used inorganic synthesis.

Uses

4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Uses

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Definition

ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.

General Description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.

Health Hazard

The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.

Fire Hazard

Flammable; flash point 36°C (97°F); vapor density 3.7 (air = 1); the vapor forms an explosive mixture with air, range is not reported. Fire-extinguishing agent: “alcohol” foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It decomposes to HCl and tetrahydrofuran on heating.

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES and ALCOHOLS.

Waste Disposal

Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.

4-Chloro-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Morpholinobutyl)hydrazine 2-(3-CHLOROPROPYL)-1,3-DIOXOLANE 4-CHLORO-BUTYRALDEHYDE 4-Amino-1-butanol 1-(4-(Pyrrolidin-1-yl)butyl)hydrazine

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4-Chloro-1-butanol Suppliers

Americas 1 Belgium 2 Canada 1 China 309 Europe 3 France 3 Germany 7 India 14 Japan 5 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 38 Global 404

Key Organics Ltd.

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Molekula Limited

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NBS Biologicals

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Manchester Organics

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Apollo Scientific Ltd.

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Leancare Ltd.

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MOLEKULA Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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ARIAC - Armenian Institute of Applied Chemistry

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Eurolabs Limited

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UK GREEN SCIENTIFIC CO.,LIMITED

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VWR International

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View Lastest Price from 4-Chloro-1-butanol manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: 4-Chloro-1-butanol 928-51-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-28

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Chloro-1-butanol 928-51-8
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Chloro-1-butanol 928-51-8
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 10 ton
Release date: 2024-08-21

928-51-8, 4-Chloro-1-butanolRelated Search:

Sodium tert-butoxide 1-Butanol tert-Butanol 2-Methyl-1-propanol Potassium tert-butoxide 3-Chloro-1,2-propanediol Ethambutol CYCLOBUTANE Epichlorohydrin TIROFIBAN HYDROCHLORIDE MONOHYDRATE 4-(4-Piperidyl)-1-butanol Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) 1-Butanesulfonyl chloride 2-butyl-4-methylpyridine L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE 1-Methylethyl 1-butanesulfonate 4,4'-Dimethyl-2,2'-bipyridyl 1-Butanesulfonic acid methyl ester

4-CHLORO-1-BUTANOL

4-CHLOROBUTANOL

4-CHLOROBUTANOL-1

TETRAMETHYLENE CHLOROHYDRIN

1-Butanol, 4-chloro-

4-Chlorbutan-1-ol

4-Chloro-1-butane-ol

4-chloro-1-butano

4-chlorobutan-1-ol

4-Choro-1-bytanol

4-CHLORO-1-BUTANOL, TECH., CA. 85%

4-Chloro-1-butanol, balance THF andHCl, 85%

4-CHLORO-1-BUTANOL TECH 85%

4-Chloro-1-butanol, tech. 85%

4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran)

4-CHLORO-1-BUTANOL GC ABOUT 90%

4-Chloro-1-butanol, 85%, balance THF and HCl

4-Chloro-1-butanol, balance THF and HCl,90-95%

4-Chloro-1-butanol ,85% [technical grade]

4-Chloro-1-butanol technical grade, ~85%

4-Chloro-1-butanol, 95%, tech.

4-Chloro-1-butanol (Technical Grade)

4 - chloride butyl alcohol

4-Chloro-1-hydroxybutane

4-Chlorobutane-1-ol

4-Chlorolbutanol

4-Chloro-n-butylclcohol

Tetramethylenechlorohydrine

4-Chloro-1-butanol, Pract.

4-Chloro-1-butanol, technical, 85%

4-ChIoro-1-butanoI

4-Chloro-1-butanol(containsvaryingamountsofTetrahydrofuran)&gt

oro-1-butanoL

928-51-8

213-175-5

ClCH24OH

C4H9OCl

CH2ClCH2CH2CH2OH

C4H9ClO

HOCH24Cl

Organic Building Blocks

Oxygen Compounds

Building Blocks

Alcohols

C2 to C6

蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides

蠅-Chloroalkanols

Alcohols

Building Blocks

C2 to C6

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds

API Intermediate

omega-Chloroalkanols

omega-Functional Alkanols, Carboxylic Acids, Amines & Halides

bc0001