ChemicalBook > CAS DataBase List > 4-Chloro-1-butanol

4-Chloro-1-butanol

Product Name
4-Chloro-1-butanol
CAS No.
928-51-8
Chemical Name
4-Chloro-1-butanol
Synonyms
4-chlorobutan-1-ol;4-CHLOROBUTANOL;oro-1-butanoL;4-Chlorolbutanol;4-Choro-1-bytanol;4-CHLOROBUTANOL-1;4-chloro-1-butano;4-Chlorbutan-1-ol;4-CHLORO-1-BUTANOL;4-ChIoro-1-butanoI
CBNumber
CB5100347
Molecular Formula
C4H9ClO
Formula Weight
108.57
MOL File
928-51-8.mol
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4-Chloro-1-butanol Property

Boiling point:
84-85 °C/16 mmHg (lit.)
Density 
1.088 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.453(lit.)
Flash point:
97 °F
storage temp. 
2-8°C
solubility 
Soluble in methanol, chloroform, and dimethyl sufoxide.
form 
Liquid
pka
15.01±0.10(Predicted)
color 
Clear colorless to light yellow
BRN 
1731408
InChIKey
HXHGULXINZUGJX-UHFFFAOYSA-N
CAS DataBase Reference
928-51-8(CAS DataBase Reference)
NIST Chemistry Reference
4-Chloro-1-butanol(928-51-8)
EPA Substance Registry System
1-Butanol, 4-chloro- (928-51-8)
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Safety

Hazard Codes 
Xn,C,F
Risk Statements 
10-22-36/37/38-20/21/22-34-40
Safety Statements 
23-24/25-36/37/39-26-16-36/37
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
RTECS 
EL1325000
Hazard Note 
Harmful
TSCA 
Yes
HazardClass 
3.2
PackingGroup 
III
HS Code 
29055910
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H290May be corrosive to metals

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H351Suspected of causing cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
278823
Product name
4-Chloro-1-butanol
Purity
technical grade, ~85%
Packaging
50ml
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
278823
Product name
4-Chloro-1-butanol
Purity
technical grade, ~85%
Packaging
250ml
Price
$309.6
Updated
2024/03/01
TCI Chemical
Product number
C0144
Product name
4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran)
Purity
>85.0%(GC)
Packaging
25g
Price
$58
Updated
2024/03/01
TCI Chemical
Product number
C0144
Product name
4-Chloro-1-butanol (contains varying amounts of Tetrahydrofuran)
Purity
>85.0%(GC)
Packaging
500g
Price
$435
Updated
2024/03/01
Alfa Aesar
Product number
L04042
Product name
4-Chloro-1-butanol, tech. 85%
Packaging
50g
Price
$72.8
Updated
2024/03/01
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4-Chloro-1-butanol Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

Tetramethylene chlorohydrin is used inorganic synthesis.

Uses

4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Uses

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.

Definition

ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.

General Description

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.

Health Hazard

The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.

Fire Hazard

Flammable; flash point 36°C (97°F); vapor density 3.7 (air = 1); the vapor forms an explosive mixture with air, range is not reported. Fire-extinguishing agent: “alcohol” foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It decomposes to HCl and tetrahydrofuran on heating.

Safety Profile

Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES and ALCOHOLS.

Waste Disposal

Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.

4-Chloro-1-butanol Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Morpholinobutyl)hydrazine 2-(3-CHLOROPROPYL)-1,3-DIOXOLANE 4-CHLORO-BUTYRALDEHYDE 4-Amino-1-butanol 1-(4-(Pyrrolidin-1-yl)butyl)hydrazine
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4-Chloro-1-butanol Suppliers

Americas 1 Belgium 2 Canada 1 China 314 Europe 3 France 3 Germany 7 India 14 Japan 5 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 38 Global 409
HBCChem, Inc.
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View Lastest Price from 4-Chloro-1-butanol manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4-Chloro-1-butanol 928-51-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-27
Hebei Yanxi Chemical Co., Ltd.
Product
4-Chloro-1-butanol 928-51-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-28
Hebei Weibang Biotechnology Co., Ltd
Product
4-Chloro-1-butanol 928-51-8
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24

928-51-8, 4-Chloro-1-butanolRelated Search:

Sodium tert-butoxide 1-Butanol tert-Butanol 2-Methyl-1-propanol Potassium tert-butoxide 3-Chloro-1,2-propanediol Ethambutol CYCLOBUTANE Epichlorohydrin TIROFIBAN HYDROCHLORIDE MONOHYDRATE 4-(4-Piperidyl)-1-butanol Tirofiban IMpurity (4,4'-Dipyridyl-1,5-Pentane) 1-Butanesulfonyl chloride 2-butyl-4-methylpyridine L-N-BUTYLSULFONYL-P-HYDROXYPHENYLALANINE 1-Methylethyl 1-butanesulfonate 4,4'-Dimethyl-2,2'-bipyridyl 1-Butanesulfonic acid methyl ester

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  • 4 - chloride butyl alcohol
  • 4-Chloro-1-hydroxybutane
  • 4-Chlorobutane-1-ol
  • 4-Chlorolbutanol
  • 4-Chloro-n-butylclcohol
  • Tetramethylenechlorohydrine
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  • 4-ChIoro-1-butanoI
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  • oro-1-butanoL
  • 928-51-8
  • 213-175-5
  • ClCH24OH
  • C4H9OCl
  • CH2ClCH2CH2CH2OH
  • C4H9ClO
  • HOCH24Cl
  • Organic Building Blocks
  • Oxygen Compounds
  • Building Blocks
  • Alcohols
  • C2 to C6
  • 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • 蠅-Chloroalkanols
  • Alcohols
  • Building Blocks
  • C2 to C6
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • API Intermediate
  • omega-Chloroalkanols
  • omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • bc0001