ChemicalBook > CAS DataBase List > Ranolazine

Ranolazine

Product Name
Ranolazine
CAS No.
122312-55-4
Chemical Name
Ranolazine
Synonyms
Ranolazine USP/EP/BP;(Mu7-((diosmin heptasulfato)(7-)))tetracontahydroxytetradecaaluminum
CBNumber
CB51031990
Molecular Formula
C28H61Al16O79S8
Formula Weight
2349.95
MOL File
122312-55-4.mol
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0152528
Product name
DOSMALFATE
Purity
97.00%
Packaging
1G
Price
$1758.49
Updated
2021/12/16
More
Less

Ranolazine Chemical Properties,Usage,Production

Description

Dosmalfate, a heptakis(hydrogensulfate) aluminium complex of diosmin, was launched in Spain for the prevention and treatment of gastroduodenal lesions induced by NSAID therapy. Dosmalfate can be prepared from diosmin by initial treatment with a pyridine sulfur trioxide complex followed by sodium hydroxide and finally aluminium hydroxychloride. In several pharmacological models of acute and chronic ulcers, this new cytoprotective agent has demonstrated significant protection against damage to the gastric mucosa or esophagus erosion, hemorrhage or perforation. Several mechanisms of action could be involved, partly mediated by the endogenous prostaglandins. In several clinical studies with patients receiving long-term NSAID therapy for chronic inflammatory disease, the efficacy of dosmalfate in preventing gastric ulcer was high and comparable to that of misoprostol, but with significantly less adverse events. In rats and humans, dosmalfate, administered orally at very high doses, displayed a very poor absorption and consequently, a very low incidence of side effects, particularly on CNS, cardiovascular or respiratory systems.

Originator

Faes (Spain)

brand name

Diotul

Ranolazine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ranolazine Suppliers

Foshan Nanhai Beisha Pharmaceutical Co., Ltd.
Tel
0757-85616808
Fax
+86-757-85669370
Email
bsyrylq@163.net
Country
China
ProdList
21
Advantage
60
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-029-89586680 +86-18192503167
Fax
+86-29-88380327
Email
1026@dideu.com
Country
China
ProdList
7724
Advantage
58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19689
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ:2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4148
Advantage
58
Sinoway Industrial co., ltd.
Tel
0592-5800732; +8613806035118
Fax
0592-5854960
Email
xie@china-sinoway.com
Country
China
ProdList
988
Advantage
58
Jinan Yufeng Bioengineering Co., Ltd
Tel
--
Fax
--
Email
sales@yufengpharm.com
Country
China
ProdList
66
Advantage
50
The Swiss biotechnology Shanghai Ltd.
Tel
--
Fax
--
Email
health@auspure.com
Country
China
ProdList
112
Advantage
34