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Ranolazine

Product Name
Ranolazine
CAS No.
122312-55-4
Chemical Name
Ranolazine
Synonyms
Ranolazine USP/EP/BP;(Mu7-((diosmin heptasulfato)(7-)))tetracontahydroxytetradecaaluminum
CBNumber
CB51031990
Molecular Formula
C28H61Al16O79S8
Formula Weight
2349.95
MOL File
122312-55-4.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CHM0152528
Product name
DOSMALFATE
Purity
97.00%
Packaging
1G
Price
$1758.49
Updated
2021/12/16
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Ranolazine Chemical Properties,Usage,Production

Description

Dosmalfate, a heptakis(hydrogensulfate) aluminium complex of diosmin, was launched in Spain for the prevention and treatment of gastroduodenal lesions induced by NSAID therapy. Dosmalfate can be prepared from diosmin by initial treatment with a pyridine sulfur trioxide complex followed by sodium hydroxide and finally aluminium hydroxychloride. In several pharmacological models of acute and chronic ulcers, this new cytoprotective agent has demonstrated significant protection against damage to the gastric mucosa or esophagus erosion, hemorrhage or perforation. Several mechanisms of action could be involved, partly mediated by the endogenous prostaglandins. In several clinical studies with patients receiving long-term NSAID therapy for chronic inflammatory disease, the efficacy of dosmalfate in preventing gastric ulcer was high and comparable to that of misoprostol, but with significantly less adverse events. In rats and humans, dosmalfate, administered orally at very high doses, displayed a very poor absorption and consequently, a very low incidence of side effects, particularly on CNS, cardiovascular or respiratory systems.

Originator

Faes (Spain)

brand name

Diotul

Ranolazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Ranolazine Suppliers

Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71