6-Amino-1-hexanol Property

Melting point:

54-58 °C (lit.)

Boiling point:

135-140 °C/30 mmHg (lit.)

Density 

0.8872 (estimate)

refractive index 

1.4444 (estimate)

Flash point:

133 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Chloroform (Slightly), Methanol (Slightly)

form 

Crystals

pka

15.18±0.10(Predicted)

color 

Light yellow to brown

Water Solubility 

MISCIBLE

Sensitive 

Hygroscopic

BRN 

1732524

Stability:

Hygroscopic. Stable. Incompatible with strong oxidizing agents.

InChIKey

SUTWPJHCRAITLU-UHFFFAOYSA-N

CAS DataBase Reference

4048-33-3(CAS DataBase Reference)

NIST Chemistry Reference

NH2(CH2)6OH(4048-33-3)

EPA Substance Registry System

1-Hexanol, 6-amino- (4048-33-3)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

RTECS 

MO8840000

F 

3-10

HazardClass 

IRRITANT, HYGROSCOPIC

HS Code 

29221990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

6-Amino-1-hexanol Chemical Properties,Usage,Production

Chemical Properties

slightly yellow crystalline powder

Uses

6-Amino-1-hexanol is used in the synthesis of guanidino analogs of roscovitine, which is a cyclin-dependant kinase. Also used in the preparation of tocotrienols which maintain anticancer, antiprolifer ative and antimigratory activity. Behery, F

Uses

6-Amino-1-hexanol is used as pharmaceutical intermediate.

Uses

6-Amino-1-hexanol can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.

Synthesis

By volume ratio, 1 part of 6-aminohexanoic acid was added to the reactor containing 15 parts of diethyl ether or dry toluene solution At 40 ℃ constant temperature, At 1500rpm / min speed, rapidly injected 2 parts of a solution of sodium borohydride. At 250W, ultrasonic treatment 20min. Then, dropwise under reflux, 8 parts of ethylene glycol solution. Dropwise addition time was 30 minutes. Finally, at 90 ℃ and at a rate of 800rpm/min, maintain temperature under stirring and react for 16 h to obtain the reaction crude product. (2) By the amount of parts count, step (1) preparation of 1 part of the reaction crude was added 6 parts water for hydrolysis. Undrego vacuum distillation, collecting 125 ℃ fraction, to obtain the 6-amino-1-hexanol product.