ChemicalBook > CAS DataBase List > Methyl 5-amino-2,4-difluorobenzoate

Methyl 5-amino-2,4-difluorobenzoate

Product Name: Methyl 5-amino-2,4-difluorobenzoate
CAS No.: 125568-73-2
Chemical Name: Methyl 5-amino-2,4-difluorobenzoate
Synonyms: Methyl 5-amino-2,4-difluorobenzoate;Methyl 5-amino-2,4-difluorobenzoate USP/EP/BP;Benzoic acid, 5-amino-2,4-difluoro-, methyl ester;Benzoic acid, 5-amino-2,4-difluoro-, methyl ester (9CI)
CBNumber: CB51070708
Molecular Formula: C8H7F2NO2
Formula Weight: 187.14
MOL File: 125568-73-2.mol

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Methyl 5-amino-2,4-difluorobenzoate Property

Boiling point:: 284.0±40.0 °C(Predicted)
Density: 1.355±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 2.12±0.10(Predicted)
Appearance: Off-white to gray Solid

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Safety

HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M328910
Product name: Methyl5-amino-2,4-difluorobenzoate
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: X9630
Product name: Methyl5-amino-2,4-difluorobenzoate
Packaging: 1g
Price: $77
Updated: 2021/12/16

AK Scientific

Product number: X9630
Product name: Methyl5-amino-2,4-difluorobenzoate
Packaging: 10g
Price: $184
Updated: 2021/12/16

Apolloscientific

Product number: PC902802
Product name: Methyl5-amino-2,4-difluorobenzoate
Purity: 98%
Packaging: 25g
Price: $275
Updated: 2021/12/16

Matrix Scientific

Product number: 074560
Product name: Methyl 5-amino-2,4-difluorobenzoate
Purity: 95+%
Packaging: 1g
Price: $301
Updated: 2021/12/16

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Methyl 5-amino-2,4-difluorobenzoate Chemical Properties,Usage,Production

Uses

Methyl 5-amino-2,4-difluorobenzoate is a carboxylic acid ester derivative used in pharmaceutical synthesis and experimental research.

Synthesis

125568-71-0

125568-73-2

General procedure for the synthesis of methyl 5-amino-2,4-difluorobenzoate from methyl 2,4-difluoro-5-nitrobenzoate: to a solution of methyl 2,4-difluoro-5-nitrobenzoate (12.0 g, 0.06 mol, 1 eq.) in acetic acid (150 mL) and water was added iron powder (12.3 g, 0.22 mol, 4 eq.). The reaction mixture was heated to 40 °C and kept for 1.5 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford methyl 5-amino-2,4-difluorobenzoate (10.0 g, 96% yield) as a brown solid.1H NMR (400 MHz, DMSO-d6) δppm: 7.27 (dd, J=9.98,7.42 Hz, 1H), 7.14 (t, J=10.99 Hz, 1H), 5.28 (s, 2H), 3.77 (s, 3H).ES-LCMS: m/z 189.0 (M+H).

References

[1] Patent: WO2009/75960, 2009, A1. Location in patent: Page/Page column 22
[2] Patent: WO2009/58919, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: WO2009/58923, 2009, A1. Location in patent: Page/Page column 12
[4] Journal of Organic Chemistry, 1990, vol. 55, # 7, p. 2034 - 2044

Methyl 5-amino-2,4-difluorobenzoate Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from Methyl 5-amino-2,4-difluorobenzoate manufacturers

Career Henan Chemical Co

Product: Methyl 5-amino-2,4-difluorobenzoate 125568-73-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

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Methyl 5-amino-2,4-difluorobenzoate USP/EP/BP

125568-73-2

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