Methyl 5-amino-2,4-difluorobenzoate
- Product Name
- Methyl 5-amino-2,4-difluorobenzoate
- CAS No.
- 125568-73-2
- Chemical Name
- Methyl 5-amino-2,4-difluorobenzoate
- Synonyms
- Methyl 5-amino-2,4-difluorobenzoate;Methyl 5-amino-2,4-difluorobenzoate USP/EP/BP;Benzoic acid, 5-amino-2,4-difluoro-, methyl ester;Benzoic acid, 5-amino-2,4-difluoro-, methyl ester (9CI)
- CBNumber
- CB51070708
- Molecular Formula
- C8H7F2NO2
- Formula Weight
- 187.14
- MOL File
- 125568-73-2.mol
Methyl 5-amino-2,4-difluorobenzoate Property
- Boiling point:
- 284.0±40.0 °C(Predicted)
- Density
- 1.355±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.12±0.10(Predicted)
- Appearance
- Off-white to gray Solid
Safety
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M328910
- Product name
- Methyl5-amino-2,4-difluorobenzoate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- X9630
- Product name
- Methyl5-amino-2,4-difluorobenzoate
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- X9630
- Product name
- Methyl5-amino-2,4-difluorobenzoate
- Packaging
- 10g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- PC902802
- Product name
- Methyl5-amino-2,4-difluorobenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 074560
- Product name
- Methyl 5-amino-2,4-difluorobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $301
- Updated
- 2021/12/16
Methyl 5-amino-2,4-difluorobenzoate Chemical Properties,Usage,Production
Uses
Methyl 5-amino-2,4-difluorobenzoate is a carboxylic acid ester derivative used in pharmaceutical synthesis and experimental research.
Synthesis
125568-71-0
125568-73-2
General procedure for the synthesis of methyl 5-amino-2,4-difluorobenzoate from methyl 2,4-difluoro-5-nitrobenzoate: to a solution of methyl 2,4-difluoro-5-nitrobenzoate (12.0 g, 0.06 mol, 1 eq.) in acetic acid (150 mL) and water was added iron powder (12.3 g, 0.22 mol, 4 eq.). The reaction mixture was heated to 40 °C and kept for 1.5 hours. After completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford methyl 5-amino-2,4-difluorobenzoate (10.0 g, 96% yield) as a brown solid.1H NMR (400 MHz, DMSO-d6) δppm: 7.27 (dd, J=9.98,7.42 Hz, 1H), 7.14 (t, J=10.99 Hz, 1H), 5.28 (s, 2H), 3.77 (s, 3H).ES-LCMS: m/z 189.0 (M+H).
References
[1] Patent: WO2009/75960, 2009, A1. Location in patent: Page/Page column 22
[2] Patent: WO2009/58919, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: WO2009/58923, 2009, A1. Location in patent: Page/Page column 12
[4] Journal of Organic Chemistry, 1990, vol. 55, # 7, p. 2034 - 2044
Methyl 5-amino-2,4-difluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 5-amino-2,4-difluorobenzoate Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from Methyl 5-amino-2,4-difluorobenzoate manufacturers
- Product
- Methyl 5-amino-2,4-difluorobenzoate 125568-73-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25