(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

Uses Preparation

Product Name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
CAS No.: 127852-28-2
Chemical Name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Synonyms: C1oHgF6O;R-MBT-PEL;(R)-1-[3,5-Bis(trifL;Aprepitant Impurity 49;Phenol,5-iodo-4-methyl-;Fosaprepitant Impurity 25;Rolapitant Intermediate 3;Thiazole,2-bromo-9-methyl-;(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et;(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL
CBNumber: CB5113482
Molecular Formula: C10H8F6O
Formula Weight: 258.16
MOL File: 127852-28-2.mol

More

Less

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Property

Melting point:: 53-58℃
Boiling point:: 175.8±35.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
pka: 13.99±0.20(Predicted)
form: Powder
color: White
optical activity: [α]/D +27±1°, c = 1 in acetonitrile
λmax: 272nm(MeOH)(lit.)
InChIKey: MMSCIQKQJVBPIR-RXMQYKEDSA-N
CAS DataBase Reference: 127852-28-2(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-52/53-22
Safety Statements: 26-36/37/39-61
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29062990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49554
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: ≥98.0% (GC)
Packaging: 5g
Price: $72
Updated: 2023/06/20

Sigma-Aldrich

Product number: 49554
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: ≥98.0% (GC)
Packaging: 25g
Price: $216
Updated: 2023/06/20

TCI Chemical

Product number: B4131
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $66
Updated: 2024/03/01

TCI Chemical

Product number: B4131
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol
Purity: >98.0%(GC)
Packaging: 25g
Price: $213
Updated: 2024/03/01

Alfa Aesar

Product number: H60893
Product name: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%
Packaging: 5g
Price: $73.08
Updated: 2023/01/06

More

Less

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Chemical Properties,Usage,Production

Uses

(R)-[3,5-bis (trifluoromethyl) phenyl] ethanol is an important chiral intermediate for the synthesis of novel chemotherapeutic and antiemetic drugs NK-1 receptor antagonists. Antidepressants have good potential efficacy in treating a range of central and peripheral nervous system depressions.

Preparation

At present, the methods for preparing optically pure (R)-[3,5-bis (trifluoromethyl) phenyl] ethanol include chemical methods and biological methods. Chemical synthesis requires the use of expensive transition metal Ru and other chemical catalysts, complicated steps, harsh reaction conditions, high energy consumption, large pollution, and low yield. Biological law is the use of free enzymes or whole cells for catalytic preparation. It has the characteristics of mild reaction conditions, high catalytic efficiency, and strong specificity.

Chemical Properties

White fine crystalline powder

Uses

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is an intermediate in the synthesis of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.

General Description

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol is a key intermediate for the synthesis of aprepitant, a potent human neurokinin-1 (NK-1) receptor.

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol Suppliers

Americas 1 Canada 1 China 345 Europe 2 France 1 Germany 7 India 20 Japan 5 Singapore 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 40 Global 435

Accela ChemBio Inc.

Tel: +1(858) 699-3322
Fax: +1(858) 876-1948
Email: marketing@accelachem.com
Country: United States
ProdList: 6024
Advantage: 65

Alfa Chemistry

Tel: 1-516-6625404
Fax: 1-516-927-0118
Email: support@alfa-chemistry.com
Country: United States
ProdList: 9171
Advantage: 60

Alfa Chemistry

Tel
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 24072
Advantage: 58

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 17322
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81215950 4000-868-328
Email: customer@uwalab.com
Country: United States
ProdList: 10404
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6075
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

BASF SE

Tel: --
Fax: --
Email: jennifer.moore-braun@basf.com
Country: United States
ProdList: 285
Advantage: 58

SynQuest Laboratories, Inc.,

Tel: --
Fax: --
Country: United States
ProdList: 2301
Advantage: 58

Chiral Quest Co Ltd

Tel: --
Fax: --
Country: United States
ProdList: 26
Advantage: 58

Alichem Inc.

Tel: --
Fax: --
Email: sales@alichem.com
Country: United States
ProdList: 6167
Advantage: 58

AstaTech, Inc.

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 904
Advantage: 58

MilliporeSigma (Sigma-Aldrich Corp.)

Tel: --
Fax: --
Email: @sial.com
Country: United States
ProdList: 5414
Advantage: 58

SK Life Science Inc.,

Tel: --
Fax: --
Country: United States
ProdList: 16
Advantage: 58

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United States
ProdList: 4583
Advantage: 58

SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)

Tel: --
Fax: --
Email: nfo@synquestlabs.com
Country: United States
ProdList: 1897
Advantage: 58

BASF Corporation (Pharmaceutical)

Tel: --
Fax: --
Country: United States
ProdList: 62
Advantage: 58

BASF Corporation

Tel: --
Fax: --
Country: United States
ProdList: 573
Advantage: 86

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

SK Energy and Chemical, Inc.

Tel: --
Fax: --
Email: info@skechem.com
Country: United States
ProdList: 78
Advantage: 50

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6962
Advantage: 56

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

AstaTech, Inc

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 6371
Advantage: 58

INDOFINE Chemical Company, Inc.

Tel: --
Fax: --
Email: chemical@indofinechemical.com
Country: United States
ProdList: 6176
Advantage: 69

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

Tel: --
Fax: --
Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

More

Less

View Lastest Price from (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol manufacturers

Hebei Dangtong Import and export Co LTD

Product: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price: US $300.00-250.00/kg
Min. Order: 100kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: (R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol 127852-28-2
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-19

Hangzhou ICH Biofarm Co., Ltd

Product: (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol 127852-28-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ≥1kg
Release date: 2023-07-18

127852-28-2, (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanolRelated Search:

2-AMINO-1-PHENYLETHANOL Diphenyl ether Chlorodimethylphenylsilane Phenyl salicylate Ethanol Silicone oil (high temperature) N-Methyldiethanolamine Ethyl acetate PHENYL VALERATE 2-Methylaminoethanol Phenethyl alcohol PHENYL RESIN methylphenyl silicone resin 2-(R)-[1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(S)-fluorophenylmorpholine 2-[3,5-Bis(trifluoromethyl)phenyl]propan-2-ol 2-Dimethylaminoethanol (S)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL,(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL Aprepitant

(R)-BIS-3,5-TRIFLUOROMETHYL-1-PHENYLETHANOL

Rolapitant Intermediate 3

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol127852-28-2

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol,99%e.e.

Fosaprepitant Impurity 25

Aprepitant Impurity 49

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol （Aprepitant）

(R)-1-[3,5-BIS(TRIFLUORO-METHYL)-PHENYL]ETHANOL 98%

(1R)-1-[3,6-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

R-MBT-PEL

(R)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)ETHAN-1-OL

(R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHANOL

(R)-1-[BIS-3,5-(TRIFLUOROMETHYL)PHENYL]ETHANOL

Benzenemethanol, a-methyl-3,5-bis(trifluoromethyl)-, (aR)-

(1R)-(+)-1-[3,5-Bis(trifluoromethyl)phenyl]ethan-1-ol

(R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethanol >=98.0% (GC)

Benzenemethanol, .alpha.-methyl-3,5-bis(trifluoromethyl)-, (.alpha.R)-

(R)-1-[3,5-Bis(trifluoromethyl) phenyl]ethanol,Aprepitant intermediate

(R)-1-[3,5-Bis(trilfuoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol &gt

(R)-1-[3,5-di (trifluoromethyl) phenyl] ethanol

(R)-1-[3,5-Bis(trifL

Benzenemethanol, α-methyl-3,5-bis(trifluoromethyl)-, (αR)-

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl Alcohol

(R)-3,5-Bis(trifluoromethyl)-alpha-methylbenzyl Alcohol

Aprepitant intermediates，(R)-1-[3,5- Bis(trifluoromethyl)phenyl]ethanol

?-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol

(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol, 98%,

(R)-1-[3,5-Bis(trifluoromethyl)phenyi]ethanol

Thiazole,2-bromo-9-methyl-

Phenol,5-iodo-4-methyl-

Benzenemethanol,α-methyl-3,5-bis(trifluoromethyl)-,(αR)-

(S)-1-(3,5-Bi(trifluoromethyl)phenyl)ethan-1-ol

(αR)-α-Methyl-3,5-bis(trifluoromethyl)benzenemethanol

(alphaR)-alpha-Methyl-3,5-bis(trifluoromethyl)-benzenemethanol

C1oHgF6O

(R)-l-(3,5-bis(trifluorom ethyl)pheny l)ethan-1 -ol

(R)-1-[3,5- Bis(trifluoromethyl)phenyl]et

127852-28-2

C10H8F7O

C10H8OF6

API intermediates

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds

127852-28-2