N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid

Product Name: N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid
CAS No.: 7365-44-8
Chemical Name: N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid
Synonyms: TES;N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID;Tes Buffer;TES,2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid, N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid;TESS;C05353;TESS-2;Tris TES;8-Fluoro-1;OmniPur TES
CBNumber: CB5114267
Molecular Formula: C6H15NO6S
Formula Weight: 229.25
MOL File: 7365-44-8.mol

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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Property

Melting point:: ~225 °C (dec.)
Density: 1.260 (estimate)
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: H₂O: 1 M at 20 °C, clear, colorless
form: Crystalline Powder
color: White
PH Range: 6.8 - 8.2
Odor: Odorless
PH: 3.5-5.0 (25℃, 1M in H2O)
pka: 7.5(at 25℃)
Water Solubility: SOLUBLE
λmax: λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045
Merck: 14,9176
BRN: 1957061
InChIKey: JOCBASBOOFNAJA-UHFFFAOYSA-N
CAS DataBase Reference: 7365-44-8(CAS DataBase Reference)
EPA Substance Registry System: Ethanesulfonic acid, 2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (7365-44-8)
Absorption: ≤0.045 at 280 in H2O at 1M
≤0.055 at 260 in H2O at 1M

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 1
TSCA: Yes
HS Code: 29221980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.05147
Product name: OmniPur® TES
Purity: TES, CAS 7365-44-8 , is a Zwitterionic buffer that is useful in the pH range of 6.8-8.2.
Packaging: 100G
Price: $192
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05147
Product name: OmniPur® TES
Purity: TES, CAS 7365-44-8 , is a Zwitterionic buffer that is useful in the pH range of 6.8-8.2.
Packaging: 1KG
Price: $1060
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1.10695
Product name: N-[Tris(hydroxymethyl)-methyl]-2-aminoethanesulfonic acid
Purity: Buffer substance TES
Packaging: 250 g
Price: $440
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1.10695
Product name: N-[Tris(hydroxymethyl)-methyl]-2-aminoethanesulfonic acid
Purity: Buffer substance TES
Packaging: 10 kg
Price: $9440
Updated: 2025/07/31

Sigma-Aldrich

Product number: 93359
Product name: TES
Purity: BioUltra, ≥99.5% (calc. based on dry substance, T)
Packaging: 25g
Price: $246
Updated: 2023/06/20

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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Chemical Properties,Usage,Production

Chemical Properties

White/clear crystalline powder

Uses

A structural analog to Tris buffer.

Uses

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid (TES) probably exists in solution as a zwitterion. Because the pKa is 7.4 (physiological pH) this buffer has considerable potential for a variety of biological applications. A buffer using TES free acid can be prepared by titrating the free acid (sc-206102) with sodium hydroxide to the desired pH, using about a half-equivalent of NaOH. Alternatively, solutions of equimolar TES free acid and TES sodium (sc-264384) can be mixed to attain a buffer of the desired pH. It has been shown to be toxic in vitro, but this toxicity may be due to its ability to form metal chelate complexes that are toxic for cells. TES is a commonly used biological buffering agent.

Definition

ChEBI: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid is a Good's buffer substance, pKa = 7.5 at 20 ℃. It is a member of ethanolamines, an amino sulfonic acid and a TES. It is functionally related to a taurine. It is a tautomer of a N-tris(hydroxymethyl)methyl-2-ammonioethanesulfonate.

Purification Methods

Crystallise the acid from hot EtOH containing a little water.

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Suppliers

Belgium 2 China 371 Europe 2 France 2 Germany 10 India 16 Japan 5 Poland 1 Switzerland 3 The Netherlands 1 United Kingdom 14 United States 45 Global 472

Buchem B.V./ Arc Technologies

Tel: --
Fax: --
Email: info@buchem.com
Country: The Netherlands
ProdList: 76
Advantage: 58

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View Lastest Price from N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid/TES 7365-44-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%-101%
Supply Ability: 500KGS
Release date: 2021-06-04

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid 7365-44-8
Price: US $0.00-0.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Apeloa production Co.,Limited

Product: TES (buffer) 7365-44-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000
Release date: 2024-06-05

7365-44-8, N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic AcidRelated Search:

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C05353

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<i>N</i>-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid

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N-tris(hydroxymethyl)methyl-2-aminoethanesulfonicaci

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3-cd]indol-6-one

5-tetrahydro-6H-azepino[5

8-Fluoro-1

N-[Tris(hydroxymethyl)metyl]-2-aminoethanesulfonic acid

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2- [[tri (hydroxymethyl) methyl] amino] ethanesulfonic acid/TRIS ethanesulfonic acid

N-Tri(hydroxymethyl)methyl-2-aminoethanesulfonic acid

EZNA MICROELUTE GEL EXTRACTION KIT

Tes(N-Tris[Hydroxymethyl]Methyl-2-AminoethanesulfonicAcid)Buffer