ChemicalBook > CAS DataBase List > 9-Aminocamptothecin

9-Aminocamptothecin

Product Name
9-Aminocamptothecin
CAS No.
91421-43-1
Chemical Name
9-Aminocamptothecin
Synonyms
NSC-603071;1H-Pyrano(3;AMinocaMptothecin;9-AMINO-CAMPTOTHECIN;CAMPTOTHECIN, 9-AMINO-;9-Aminocamptothecin >Camptothecin Impurity 14;(20S)-9-AMINOCAMPTOTHECIN;9-Aminocamptothecin, >96%;9-amino-2(S)-camptothecin
CBNumber
CB5125434
Molecular Formula
C20H17N3O4
Formula Weight
363.37
MOL File
91421-43-1.mol
More
Less

9-Aminocamptothecin Property

Melting point:
142.0-145.0 °C
Boiling point:
819.6±65.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
≤1mg/ml in DMSO;1mg/ml in dimethyl formamide
form 
powder to crystal
pka
11.23±0.20(Predicted)
color 
Light yellow to Yellow to Orange
Merck 
14,431
InChIKey
FUXVKZWTXQUGMW-FQEVSTJZSA-N
CAS DataBase Reference
91421-43-1(CAS DataBase Reference)
More
Less

Safety

RTECS 
UQ0490500
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
A2063
Product name
9-Aminocamptothecin
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$485
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
17232
Product name
9-amino Camptothecin
Purity
≥95%
Packaging
25mg
Price
$381
Updated
2024/03/01
More
Less

9-Aminocamptothecin Chemical Properties,Usage,Production

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

9-Aminocamptothecin Suppliers

Americas 1 Canada 2 China 149 China Hong Kong 1 Czech Republic 1 Europe 3 Germany 4 India 5 Japan 1 Switzerland 1 United Kingdom 6 United States 31 Global 205
Xunteng International Trading Co.,Limited
Tel
Country
China Hong Kong
ProdList
878
Advantage
55
More
Less

View Lastest Price from 9-Aminocamptothecin manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
9-Aminocamptothecin 91421-43-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Shochem(Shanghai) Co.,Ltd
Product
9-Aminocamptothecin 91421-43-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
95%
Supply Ability
1kg/month
Release date
2020-04-20
Career Henan Chemical Co
Product
9-Aminocamptothecin 91421-43-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2019-12-31

91421-43-1, 9-AminocamptothecinRelated Search:

10-Hydroxycamptothecin Glycine Betaine (+)-Camptothecin ALTRENOGEST 4-Ethyl-4,10-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Rubitecan 9-methoxy-7-ethylcamptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Camptothecin 20R-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin 9-amino-20-camptothecin Hydroxyl camptothecine AMINO ACIDS 9-Aminocamptothecin

  • 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione
  • 4':6,7)indolizino(1,2-B)quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (S)-
  • CAMPTOTHECIN, 9-AMINO-(RG)
  • (S)-10-AMino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]-indolizino[1,2-b]quinoline-3,14(4H,12H)-di
  • CAMPTOTHECIN, 9-AMINO-
  • AMinocaMptothecin
  • 9-AMINO-CAMPTOTHECIN
  • 9-Amino-20-(S)-camptothecin
  • 10-amino-4(s)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
  • (20S)-9-AMINOCAMPTOTHECIN
  • 9-Aminocamptothecin, >96%
  • 2-aminobenzoic acid [(2R,3S,4R,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]-3-oxolanyl] ester
  • 9-Aminocamptothecin，9-Amino-20-(S)-camptothecin
  • (4S)-4α-Ethyl-4,12-dihydro-4-hydroxy-10-amino-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
  • 9-Amino-20(S)-camptothecine
  • NSC-603071
  • (S)-10-Amino-4-ethyl-4-hydroxy-1H-pyrano(3
  • 1H-Pyrano(3
  • 9-Aminocamptothecin, 98%, from the fruit of Camptotheca acuminata Decne.
  • 9-Aminocamptothecin &gt
  • 9-amino-2(S)-camptothecin
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-amino-4-ethyl-4-hydroxy-, (4S)-
  • Camptothecin Impurity 14
  • 91421-43-1
  • C20H17N3O4
  • Pharmaceutical Raw Materials
  • Alkaloids
  • Natural Anti-cancer Medical Materials and It's Derivatives