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SPERMINE NONOATE

Product Name
SPERMINE NONOATE
CAS No.
136587-13-8
Chemical Name
SPERMINE NONOATE
Synonyms
NOC-22;SPER/NO;SPERMINE NONOATE;Spermine NONOate,97%;SpermineNONOate,SPER/NO;Spermine Bis(NO) Adduct;SPERMINE/NITRIC OXIDE COMPLEX;SPERMINE BIS (NITRIC OXIDE) ADDUCT;SPERMINE/NITRIC OXIDE COMPLEX (SPER/NO);Spermine-Nitric oxide complex hydrate
CBNumber
CB5128354
Molecular Formula
C10H26N6O2
Formula Weight
262.35
MOL File
136587-13-8.mol
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SPERMINE NONOATE Property

Melting point:
105-107°C
Boiling point:
405.6°C (rough estimate)
Density 
1.0879 (rough estimate)
refractive index 
1.7000 (estimate)
storage temp. 
-20°C
solubility 
methanol: ≥1mg/mL
form 
White solid
pka
5.47±0.69(Predicted)
color 
white
Stability:
Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Buffer solutions are not stable and must be prepared immediately before use.
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Safety

Safety Statements 
22-24/25
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S150
Product name
Spermine–Nitric oxide complex
Purity
source of nitric oxide
Packaging
25mg
Price
$197
Updated
2021/12/16
Cayman Chemical
Product number
82150
Product name
Spermine NONOate
Purity
≥98%
Packaging
10mg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
82150
Product name
Spermine NONOate
Purity
≥98%
Packaging
25mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
82150
Product name
Spermine NONOate
Purity
≥98%
Packaging
50mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
82150
Product name
Spermine NONOate
Purity
≥98%
Packaging
100mg
Price
$302
Updated
2024/03/01
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SPERMINE NONOATE Chemical Properties,Usage,Production

Description

Spermine NONOate (136587-13-8) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner.? ? The half-life of Spermine NONOate in 0.1 M phosphate buffer at pH 7.4 is 39 min at 37 °C, or 230 min at room temperature.1? ? Dissociation is essentially instantaneous at a pH of 5.0.

Chemical Properties

Off-White Solid

Uses

A reagent which releases Nitric Oxide into aqueous solutions at controlled rates for in vitro studies.

General Description

Complex of nitric oxide (NO) with spermine. Convenient reagent for preparing aqueous solutions of NO. Half-life (t?) of NO release = 230 min (PBS, pH 7.4, 22°C).

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC 50 = 6.2 μ M for relaxation of rabbit aorta, and t=39 min at 37℃, pH 7.4, aqueous solution).

Biochem/physiol Actions

Product does not compete with ATP.

References

1) Keefer et al. (1996), “NONOates” (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol., 268 281

SPERMINE NONOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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SPERMINE NONOATE Suppliers

Canada 1 China 37 Germany 1 India 1 Japan 1 Switzerland 3 United Kingdom 5 United States 21 Global 70
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from SPERMINE NONOATE manufacturers

Guangzhou Sunton Biotechnology Co., Ltd.
Product
Spermine NONOate 136587-13-8
Price
US $48.00-40.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200tons
Release date
2021-04-15

136587-13-8, SPERMINE NONOATERelated Search:

Sodium nitroprusside dihydrate NOC-18 DPTA NONOATE NOC-7 MAHMA NONOATE 4-(N-CYANOMETHYL-N-NITROSO)AMINOMORPHOLINE S-NITROSOGLUTATHIONE NOC-5 BETA-GAL-NONOATE GEA 3162 NOR-3 Ethylenediamine NITRIC OXIDE Dipentene SPERMINE DIHYDRATE SPERMINE NONOATE PAPA NONOATE DEA NONOATE

  • (Z)-1-[N-[3-AMINOPROPYL]-N-[4-(3-AMINOPROPYL-AMMONIO)BUTYL]-AMINO]-DIAZEN-1-IUM-1,2-DIOLATE
  • (Z)-1-[N-(3-AMMONIOPROPYL)-N-[4-(3-AMINOPROPYLAMMONIO) BUTYL]-AMINO]DIAZEN-1-IUM-1,2-DIOLATE
  • SPERMINE BIS (NITRIC OXIDE) ADDUCT
  • SPERMINE/NITRIC OXIDE COMPLEX
  • SPERMINE NONOATE
  • SPER/NO
  • NOC-22
  • N-[4-[1-(3-AMINOPROPYL)-2-HYDROXY-2-NITROSOHYDRAZINO]BUTYL]-1,3-PROPANEDIAMINE
  • N-(2-AMINOETHYL)-N-(2-HYDROXY-2-NITROSOHYDRAZINO)-1,2-ETHYLENEDIAMINE
  • N-(2-AMINOETHYL)-N-(2-HYDROXY-3-NITROSOHYDRAZINO)-1,2-ETHYLENEDIAMINE
  • SPERMINE/NITRIC OXIDE COMPLEX (SPER/NO)
  • SpermineNONOate,SPER/NO
  • N1-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]-1,3-propanediamine
  • Spermine Bis(NO) Adduct
  • SPER/NO, Spermine NONOate, N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine
  • Spermine-Nitric oxide complex hydrate
  • Spermine NONOate,97%
  • N'-(3-aMinopropyl)-N'-(4-((3-aMinopropyl)aMino)butyl)-N-hydroxynitrous hydrazide hydrate
  • Spermine NONOate - CAS 136587-13-8 - Calbiochem
  • N'-(3-Aminopropyl)-N'-(4-((3-aminopropyl)amino)butyl)-N-hydroxynitrous hydrazide
  • 1,3-Propanediamine, N1-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazinyl]butyl]-
  • 136587-13-8
  • C10H26N6O2H2O
  • C10H26N6O2
  • Application Index
  • Cell Signaling Enzymes
  • Biochemicals and Reagents
  • BioChemical
  • NO Donors
  • Nitric Oxide Metabolism
  • Enzymes, Inhibitors, and Substrates
  • Nitric Oxide Reagents
  • Amines