6-hydroxydexamethasone
- Product Name
- 6-hydroxydexamethasone
- CAS No.
- 55879-47-5
- Chemical Name
- 6-hydroxydexamethasone
- Synonyms
- 6-hydroxydexamethasone;6β-hydroxy Dexamethasone;Dexamethasone Impurity 12;Dexamethasone 6β-Hydroxy Impurity;Dexamethasone 6beta-Hydroxy Impurity;6-Hydroxydexamethasone Solution, 100ppm;(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
- CBNumber
- CB51341435
- Molecular Formula
- C22H29FO6
- Formula Weight
- 408.46
- MOL File
- 55879-47-5.mol
6-hydroxydexamethasone Property
- Melting point:
- 259-262°C
- Boiling point:
- 613.2±55.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Dioxane (Very Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- pka
- 12.06±0.70(Predicted)
- color
- White to Light Yellow
- InChIKey
- RVBSTEHLLHXILB-QIKGXCFKNA-N
- SMILES
- C1[C@]2(C)[C@]3(F)[C@@H](O)C[C@]4(C)[C@](O)(C(CO)=O)[C@@H](C)C[C@@H]4[C@@H]3C[C@@H](O)C2=CC(=O)C=1 |&1:1,3,5,8,10,16,19,20,22,r|
N-Bromosuccinimide Price
- Product number
- 22099
- Product name
- 6β-hydroxy Dexamethasone
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $214
- Updated
- 2023/06/20
- Product number
- 22099
- Product name
- 6β-hydroxy Dexamethasone
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $405
- Updated
- 2023/06/20
- Product number
- H939500
- Product name
- 6β-HydroxyDexamethasone
- Packaging
- 2.5mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- MTB0002203
- Product name
- 6-BETA-HYDROXY DEXAMETHASONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.21
- Updated
- 2021/12/16
- Product number
- 3637CA
- Product name
- 6beta-Hydroxydexamethasone
- Packaging
- 1mg
- Price
- $559
- Updated
- 2021/12/16
6-hydroxydexamethasone Chemical Properties,Usage,Production
Description
6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.
Chemical Properties
Off-White Solid
Uses
The hydrophilic metabolite of Dexamethasone (D298800).
References
[1] D M GENTILE. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 1: 105-112.
[2] JAMES C. RITCHIE . Preliminary studies of 6β-hydroxydexamethasone and its importance in the DST[J]. Biological Psychiatry, 1992, 32 9: Pages 825-833. DOI: 10.1016/0006-3223(92)90086-f
6-hydroxydexamethasone Preparation Products And Raw materials
Raw materials
Preparation Products
6-hydroxydexamethasone Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71