6-hydroxydexamethasone

Product Name: 6-hydroxydexamethasone
CAS No.: 55879-47-5
Chemical Name: 6-hydroxydexamethasone
Synonyms: 6-hydroxydexamethasone;6β-hydroxy Dexamethasone;Dexamethasone Impurity 12;Dexamethasone 6β-Hydroxy Impurity;Dexamethasone 6beta-Hydroxy Impurity;6-Hydroxydexamethasone Solution, 100ppm;(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CBNumber: CB51341435
Molecular Formula: C22H29FO6
Formula Weight: 408.46
MOL File: 55879-47-5.mol

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6-hydroxydexamethasone Property

Melting point:: 259-262°C
Boiling point:: 613.2±55.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Dioxane (Very Slightly, Sonicated), Methanol (Slightly)
form: Solid
pka: 12.06±0.70(Predicted)
color: White to Light Yellow
InChIKey: RVBSTEHLLHXILB-QIKGXCFKNA-N
SMILES: C1[C@]2(C)[C@]3(F)[C@@H](O)C[C@]4(C)[C@](O)(C(CO)=O)[C@@H](C)C[C@@H]4[C@@H]3C[C@@H](O)C2=CC(=O)C=1 |&1:1,3,5,8,10,16,19,20,22,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22099
Product name: 6β-hydroxy Dexamethasone
Purity: ≥98%
Packaging: 500μg
Price: $214
Updated: 2023/06/20

Cayman Chemical

Product number: 22099
Product name: 6β-hydroxy Dexamethasone
Purity: ≥98%
Packaging: 1mg
Price: $405
Updated: 2023/06/20

TRC

Product number: H939500
Product name: 6β-HydroxyDexamethasone
Packaging: 2.5mg
Price: $215
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0002203
Product name: 6-BETA-HYDROXY DEXAMETHASONE
Purity: 95.00%
Packaging: 5MG
Price: $496.21
Updated: 2021/12/16

AK Scientific

Product number: 3637CA
Product name: 6beta-Hydroxydexamethasone
Packaging: 1mg
Price: $559
Updated: 2021/12/16

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6-hydroxydexamethasone Chemical Properties,Usage,Production

Description

6β-hydroxy Dexamethasone is a metabolite of dexamethasone (Item Nos. 11015 | 20340) that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans. The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

Chemical Properties

Off-White Solid

Uses

The hydrophilic metabolite of Dexamethasone (D298800).

References

[1] D M GENTILE. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 1: 105-112.
[2] JAMES C. RITCHIE . Preliminary studies of 6β-hydroxydexamethasone and its importance in the DST[J]. Biological Psychiatry, 1992, 32 9: Pages 825-833. DOI: 10.1016/0006-3223(92)90086-f

6-hydroxydexamethasone Preparation Products And Raw materials

Raw materials

Preparation Products

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6-hydroxydexamethasone Suppliers

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55879-47-5, 6-hydroxydexamethasoneRelated Search:

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6-hydroxydexamethasone

Dexamethasone 6β-Hydroxy Impurity

Dexamethasone Impurity 12

6-Hydroxydexamethasone Solution, 100ppm

(6R,8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

Dexamethasone 6beta-Hydroxy Impurity

6β-hydroxy Dexamethasone

55879-47-5

C22H29FO6

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Steroids