baohuoside I
- Product Name
- baohuoside I
- CAS No.
- 113558-15-9
- Chemical Name
- baohuoside I
- Synonyms
- Icarisid;Icariin II;baohuoside;icarisid Ⅱ;Icarisid II;Baohuside I;BaohuosideⅠ;Baohuoside-1;baohuoside I;Bahoroside I
- CBNumber
- CB51382373
- Molecular Formula
- C27 H30 O10
- Formula Weight
- 514.52
- MOL File
- 113558-15-9.mol
baohuoside I Property
- Melting point:
- 202-203 °C
- Boiling point:
- 759.4±60.0 °C(Predicted)
- Density
- 1.46
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO, Methanol
- pka
- 6.29±0.40(Predicted)
- form
- Solid
- color
- Light Yellow
- optical activity
- [α]/D -101 to -129°, c =0.5 in ethanol
- InChIKey
- NGMYNFJANBHLKA-MNYOFVDPNA-N
- SMILES
- C(C1C(=CC(O)=C2C(C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)=C(C3C=CC(OC)=CC=3)OC=12)=O)O)C=C(C)C |&1:10,12,14,16,18,r|
Safety
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H272May intensify fire; oxidizer
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P220Keep/Store away from clothing/…/combustible materials.
P221Take any precaution to avoid mixing with combustibles/…
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML3174
- Product name
- Icariside II
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $86.92
- Updated
- 2025/07/31
- Product number
- SML3174
- Product name
- Icariside II
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $369
- Updated
- 2025/07/31
- Product number
- B6443
- Product name
- Baohuoside I
- Packaging
- 25MG
- Price
- $289
- Updated
- 2025/07/31
- Product number
- 25062
- Product name
- Baohuoside I
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 25062
- Product name
- Baohuoside I
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $122
- Updated
- 2024/03/01
baohuoside I Chemical Properties,Usage,Production
Chemical Properties
Yellow needle-shaped crystals, soluble in methanol, derived from the whole herb of Epimedium.
Uses
Baohuoside I is an inhibitor of cell growth and also is a down-regulator of durvivin and cyclin D1 expression. Used in the treatment of esophageal cancer. Anti-cancer agent.
Definition
ChEBI: A glycosyloxyflavone that is 3,5,7-trihydroxy-4'-methoxy-8-prenylflavone in which the hydroxy group at position 3 has been converted to its alpha-L-rhamnopyranoside.
Biological Activity
Icariside II (Baohuoside-I) is a flavonoid with cytoprotective, neuroprotective, antiproliferative, and erectile function properties.
Synthesis
489-32-7
113558-15-9
The general procedure for the synthesis of 5,7-dihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-benzopyran-4-one from Icariin was performed as follows: firstly, mycelia from agar slants ( 2 cm2) of C. blakesleeana mycelium was transferred to 100 mL of medium and incubated at 30 °C and 175 rpm for 36 h to prepare the inoculum. Subsequently, 10 mL of inoculum was added to 1000 mL of liquid medium and the flasks were placed on a rotary shaker and pre-cultured for 36 h at 175 rpm, 30°C. After completion of the pre-culture, 100 mg of Icariin was dissolved in 2 mL of methanol and added to 2 L of medium for preparative biotransformation to reach a final concentration of 50 mg/L. After continuing the culture for 5 days, the culture was filtered, and the filtrate was extracted five times with equal volumes of EtOAc. At the same time, suspension cells of C. blakesleeana (5.2 g) were extracted using 1000 mL EtOAc. All EtOAc extracts were combined and concentrated under reduced pressure. The resulting residue (1.6 g) was upsampled onto an ODS column (200 g, 10 cm × 50 cm) and eluted with MeOH-H?O (10% to 90% gradient, flow rate 2.0 mL/min). Finally, 90.1 mg of icariside II was obtained from the 60% MeOH-eluted grade (500 mL) with a purity of 96.5%.
References
[1] Journal of Molecular Catalysis B: Enzymatic, 2015, vol. 122, p. 141 - 146
[2] Patent: CN104530127, 2016, B. Location in patent: Paragraph 0156-0159
[3] Patent: CN104387430, 2017, B. Location in patent: Paragraph 0109; 0110; 0111; 0112
[4] Journal of Natural Products, 2008, vol. 71, # 9, p. 1513 - 1517
[5] Journal of Asian Natural Products Research, 2015, vol. 17, # 6, p. 656 - 661
baohuoside I Preparation Products And Raw materials
Raw materials
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View Lastest Price from baohuoside I manufacturers
- Product
- baohuoside 113558-15-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-12-11
- Product
- baohuoside I 113558-15-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-07
- Product
- Baohuoside I Icariside II 113558-15-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-07