2-Amino-5-nitrothiazole Property

Melting point:

195-200 °C (dec.) (lit.)

Boiling point:

345.1±15.0 °C(Predicted)

Density 

1.583 (estimate)

refractive index 

1.6740 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

95% ethanol: soluble1g/150g at 20°C

form 

Powder

pka

1.26±0.10(Predicted)

color 

Yellow

Water Solubility 

<0.1 g/100 mL at 20 ºC

Sensitive 

Light Sensitive

Merck 

14,457

BRN 

126797

Stability:

Stable. Incompatible with strong acids, strong oxidizing agents, acid chlorides, acid anhydrides.

InChIKey

MIHADVKEHAFNPG-UHFFFAOYSA-N

CAS DataBase Reference

121-66-4(CAS DataBase Reference)

IARC

3 (Vol. 31, Sup 7) 1987

EPA Substance Registry System

2-Amino-5-nitrothiazole (121-66-4)

Safety

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

XJ2800000

F 

8

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29341000

Hazardous Substances Data

121-66-4(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Amino-5-nitrothiazole Chemical Properties,Usage,Production

Uses

Niltazoxanide USP Related Compound A 2-Amino-5-nitrothiazole.

Chemical Properties

greenish yellow, to orange or brown powder

Uses

2-Amino-5-nitrothiazole was used as diazo component in the synthesis of monoazo disperse dyes. It was used as matrix during matrix-assisted laser desorption/ionization time-of-flight mass spectrometric study of oligonucleotide and protein.

Definition

ChEBI: 2-Amino-5-nitrothiazole is a member of thiazoles and a C-nitro compound.

Production Methods

Early production of 2-Amino-5-nitrothiazole was based on nitration of 2-acetylaminothiazole and careful hydrolysis. Direct nitration of 2-aminothiazole gives a cleaner product and is best achieved by adding 2-aminothiazole nitrate [57530-25-3] to concentrated sulfuric acid at 0 – 10 ℃. This process and the nitration of o-anisidine are the only large-scale processes based on rearrangement of an amine nitrate, and both are potentially hazardous due to the possibility of runaway exothermic reactions.

General Description

Greenish-yellow to orange-yellow fluffy powder or a brown chunky powder. Slightly bitter taste. Used as a veterinary medicine.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Amino-5-nitrothiazole may be sensitive to light. Incompatible with nitric acid and sulfuric acid. Also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. A preparative hazard .

Fire Hazard

Flash point data for 2-Amino-5-nitrothiazole are not available. 2-Amino-5-nitrothiazole is probably combustible.

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SO,. Incompatible with HNO3 and H2SO4. An antiprotozoal agent.

Potential Exposure

2-Amino-5-nitrothiazole is a synthetic veterinary antiprotozoal agent used since 1950 to treat farm fowl and pigeons. It is also used as an intermediate in manufacturing a group of dyes known as disperse azo dyes. It is not known to occur as a natural product. People may be exposed to 2-amino-5-nitrothiazole through contact with birds treated with the drug, releases from poultry farms, and occupational exposures in the dye industry.