Maleimido-Tri(Ethylene Glycol)-Propionic Acid
- Product Name
- Maleimido-Tri(Ethylene Glycol)-Propionic Acid
- CAS No.
- 518044-40-1
- Chemical Name
- Maleimido-Tri(Ethylene Glycol)-Propionic Acid
- Synonyms
- 3-(2-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid;Mai-PEG3-acid;Mal-PEG3-acid;Mal-PEG3-COOH;Mal-PEG3-C2-COOH;Mal-PEG3-CH2CH2COOH;Maleimide-PEG3-CH2CH2COOH;Maleimido-Tri(Ethylene Glycol)-Propionic Acid;3-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]propanoic acid;3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid
- CBNumber
- CB51562148
- Molecular Formula
- C13H19NO7
- Formula Weight
- 301.29
- MOL File
- 518044-40-1.mol
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Property
- Boiling point:
- 491.4±40.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- pka
- 4.28±0.10(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0107746
- Product name
- Maleimido-tri(ethyleneglycol)-propionicacid
- Packaging
- 100mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- BP-21565
- Product name
- Mal-PEG3-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- POL0002467
- Product name
- MAL-PEG3-ACID
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $525
- Updated
- 2021/12/16
- Product number
- BP-21565
- Product name
- Mal-PEG3-acid
- Purity
- 98%
- Packaging
- 500mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- BP-21565
- Product name
- Mal-PEG3-acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $1350
- Updated
- 2021/12/16
Maleimido-Tri(Ethylene Glycol)-Propionic Acid Chemical Properties,Usage,Production
Description
Mal-PEG3-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It was used in the preparation of neolymphostin-based ADC precursors for the conjugation of site-specific cysteine mutant trastuzumab-A114C. Maleimido-tri(ethylene glycol)-propionic acid can also be used as a PEG-based PROTAC Linker for the synthesis of PROTACs.
in vitro
Mal-PEG3-C2-acid can be used to synthesize linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7. ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively. ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 195 and 202 nM, respectively. ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 286 and 274 nM, respectively.
target
| Cleavable
| PEGs
|