ChemicalBook > CAS DataBase List > Maleimido-Tri(Ethylene Glycol)-Propionic Acid

Maleimido-Tri(Ethylene Glycol)-Propionic Acid

Product Name
Maleimido-Tri(Ethylene Glycol)-Propionic Acid
CAS No.
518044-40-1
Chemical Name
Maleimido-Tri(Ethylene Glycol)-Propionic Acid
Synonyms
3-(2-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid;Mai-PEG3-acid;Mal-PEG3-acid;Mal-PEG3-COOH;Mal-PEG3-C2-COOH;Mal-PEG3-CH2CH2COOH;Maleimide-PEG3-CH2CH2COOH;Maleimido-Tri(Ethylene Glycol)-Propionic Acid;3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid;3-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]ethoxy]ethoxy]propanoic Acid
CBNumber
CB51562148
Molecular Formula
C13H19NO7
Formula Weight
301.29
MOL File
518044-40-1.mol
More
Less

Maleimido-Tri(Ethylene Glycol)-Propionic Acid Property

Boiling point:
491.4±40.0 °C(Predicted)
Density 
1.293±0.06 g/cm3(Predicted)
pka
4.28±0.10(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0107746
Product name
Maleimido-tri(ethyleneglycol)-propionicacid
Packaging
100mg
Price
$300
Updated
2021/12/16
BroadPharm
Product number
BP-21565
Product name
Mal-PEG3-acid
Purity
98%
Packaging
100mg
Price
$320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
POL0002467
Product name
MAL-PEG3-ACID
Purity
95.00%
Packaging
100MG
Price
$525
Updated
2021/12/16
BroadPharm
Product number
BP-21565
Product name
Mal-PEG3-acid
Purity
98%
Packaging
500mg
Price
$850
Updated
2021/12/16
BroadPharm
Product number
BP-21565
Product name
Mal-PEG3-acid
Purity
98%
Packaging
1g
Price
$1350
Updated
2021/12/16
More
Less

Maleimido-Tri(Ethylene Glycol)-Propionic Acid Chemical Properties,Usage,Production

Description

Mal-PEG3-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It was used in the preparation of neolymphostin-based ADC precursors for the conjugation of site-specific cysteine mutant trastuzumab-A114C. Maleimido-tri(ethylene glycol)-propionic acid can also be used as a PEG-based PROTAC Linker for the synthesis of PROTACs.

in vitro

Mal-PEG3-C2-acid can be used to synthesize linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7. ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively. ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 195 and 202 nM, respectively. ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 286 and 274 nM, respectively.

target

Maleimido-Tri(Ethylene Glycol)-Propionic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Maleimido-Tri(Ethylene Glycol)-Propionic Acid Suppliers

China 53 India 1 United Kingdom 1 United States 6 Global 61
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
Advantage
66
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12742
Advantage
55
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5877
Advantage
58
Tel
19916721580
Fax
QQ：3154870176
Email
info@mashilabs.com
Country
China
ProdList
4115
Advantage
58
Tel
21-65679720
Fax
0086-21-5186 1128
Email
service@speedchemical.com
Country
China
ProdList
604
Advantage
55
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6357
Advantage
58
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28821
Advantage
58
Tel
571-85586718 +8613336195806
Fax
+86-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
29797
Advantage
60
Tel
025-66028182 18112977050
Fax
(3)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
15820
Advantage
58
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
Advantage
58
Tel
0411-39042497
Fax
0411-39042693
Email
sales@alphabiopharm.com
Country
China
ProdList
1951
Advantage
58
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Tel
+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
Country
China
ProdList
1947
Advantage
58
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
12722
Advantage
58
Tel
+86-0571-81612335 +8613336028439
Email
sales@nextpeptide.com
Country
China
ProdList
19915
Advantage
58
Tel
571-86758373 +8613588754946
Fax
0086-571-81131109
Email
sales@huarongpharm.com
Country
CHINA
ProdList
3149
Advantage
58
Tel
029-86217788 13892832556
Email
2440688701@qq.com
Country
China
ProdList
1992
Advantage
58
Tel
15990591583
Fax
qq: 1050376806 mailbox : sales@nbpharmabridge.com
Country
China
ProdList
5560
Advantage
58
Tel
+86-023-61398051 +8613650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2351
Advantage
58
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49323
Advantage
58
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26033
Advantage
58
Tel
0371-53736046 13393710386
Fax
QQ:2853979814
Email
2853979814@qq.com
Country
China
ProdList
10005
Advantage
58
Tel
4000-360-990 15268198094
Email
sales@torreybio.com
Country
China
ProdList
2655
Advantage
58
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31163
Advantage
58
Tel
13303867194
Email
3001317055@qq.com
Country
China
ProdList
9839
Advantage
58
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39997
Advantage
58
Tel
400-400-6966-012-012 17778955912
Email
2957605606@qq.com
Country
China
ProdList
2535
Advantage
58
Tel
19372841038 19372841038
Email
lixing@pharmahuici.com
Country
China
ProdList
216
Advantage
58
Tel
15841022315
Email
sales@affinitytech.cn
Country
China
ProdList
2480
Advantage
58
Tel
17717618050
Email
zllg@gh-reagent.com
Country
China
ProdList
10424
Advantage
58
Tel
0431-80514535 19917294565
Email
et@chemextension.com
Country
China
ProdList
5061
Advantage
58
Tel
3456065315 13260619011
Email
3456065315@qq.com
Country
China
ProdList
1708
Advantage
58
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50471
Advantage
58
Tel
13271120151
Email
1124560377@qq.com
Country
China
ProdList
333
Advantage
58
Tel
17882285575
Email
1276966012@qq.com
Country
China
ProdList
352
Advantage
58
Tel
021-57520305 15801958784
Email
lihua@jskchem.com
Country
China
ProdList
49036
Advantage
58
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
5019
Advantage
58
Tel
0372-15803728682 15803728682
Email
hnkmy2023@163.com
Country
China
ProdList
517
Advantage
58
Tel
028-85632863 18048500443
Fax
028-85632863
Email
sales@micxy.com
Country
China
ProdList
10476
Advantage
58
Tel
13771642864
Fax
1078336263
Email
snhuyu_2008@126.com
Country
China
ProdList
1028
Advantage
58
Tel
021-50795510 4000665055
Email
sy-c5@accelachem.com
Country
China
ProdList
10368
Advantage
58
Tel
189-25112307 18925113981
Email
3809205144@qq.com
Country
China
ProdList
10002
Advantage
58
Tel
18143011203
Email
ET-market@chemextension.com
Country
China
ProdList
36693
Advantage
58
Tel
3674309880
Email
hanfangpharma@126.com
Country
China
ProdList
30968
Advantage
58
Tel
+86-15680926068 +86-15680926068
Email
1924344760@confluore.cn
Country
China
ProdList
2996
Advantage
58
More
Less

View Lastest Price from Maleimido-Tri(Ethylene Glycol)-Propionic Acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Mal-PEG3-acid 518044-40-1
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-27

518044-40-1, Maleimido-Tri(Ethylene Glycol)-Propionic AcidRelated Search:

Mal-PEG4-Acid Mal-PEG1-NHS ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Mal-PEG2-amine Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester 3,4-Dibromo-Mal-PEG2-Amine Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid Mal-Amido-PEG4-acid

  • 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid
  • Mal-PEG3-acid
  • Maleimide-PEG3-CH2CH2COOH
  • Mal-PEG3-COOH
  • Mal-PEG3-CH2CH2COOH
  • Maleimido-Tri(Ethylene Glycol)-Propionic Acid
  • 3-(2-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid
  • Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-
  • 3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid
  • Mai-PEG3-acid
  • Mal-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-
  • Mal-PEG3-C2-COOH
  • 3-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]ethoxy]ethoxy]propanoic Acid
  • 518044-40-1
  • C13H19NO7
  • peg

    • Cleavable

    PEGs