ChemicalBook > CAS DataBase List > Maleimido-Tri(Ethylene Glycol)-Propionic Acid

Maleimido-Tri(Ethylene Glycol)-Propionic Acid

Product Name
Maleimido-Tri(Ethylene Glycol)-Propionic Acid
CAS No.
518044-40-1
Chemical Name
Maleimido-Tri(Ethylene Glycol)-Propionic Acid
Synonyms
3-(2-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid;Mai-PEG3-acid;Mal-PEG3-acid;Mal-PEG3-COOH;Mal-PEG3-C2-COOH;Mal-PEG3-CH2CH2COOH;Maleimide-PEG3-CH2CH2COOH;Maleimido-Tri(Ethylene Glycol)-Propionic Acid;3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid;3-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]ethoxy]ethoxy]propanoic Acid
CBNumber
CB51562148
Molecular Formula
C13H19NO7
Formula Weight
301.29
MOL File
518044-40-1.mol
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Maleimido-Tri(Ethylene Glycol)-Propionic Acid Property

Boiling point:
491.4±40.0 °C(Predicted)
Density 
1.293±0.06 g/cm3(Predicted)
pka
4.28±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0107746
Product name
Maleimido-tri(ethyleneglycol)-propionicacid
Packaging
100mg
Price
$300
Updated
2021/12/16
BroadPharm
Product number
BP-21565
Product name
Mal-PEG3-acid
Purity
98%
Packaging
100mg
Price
$320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
POL0002467
Product name
MAL-PEG3-ACID
Purity
95.00%
Packaging
100MG
Price
$525
Updated
2021/12/16
BroadPharm
Product number
BP-21565
Product name
Mal-PEG3-acid
Purity
98%
Packaging
500mg
Price
$850
Updated
2021/12/16
BroadPharm
Product number
BP-21565
Product name
Mal-PEG3-acid
Purity
98%
Packaging
1g
Price
$1350
Updated
2021/12/16
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Maleimido-Tri(Ethylene Glycol)-Propionic Acid Chemical Properties,Usage,Production

Description

Mal-PEG3-acid is a PEG linker containing a maleimide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Biological Activity

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It was used in the preparation of neolymphostin-based ADC precursors for the conjugation of site-specific cysteine mutant trastuzumab-A114C. Maleimido-tri(ethylene glycol)-propionic acid can also be used as a PEG-based PROTAC Linker for the synthesis of PROTACs.

in vitro

Mal-PEG3-C2-acid can be used to synthesize linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7. ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively. ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 195 and 202 nM, respectively. ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC 50 of 286 and 274 nM, respectively.

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Maleimido-Tri(Ethylene Glycol)-Propionic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Maleimido-Tri(Ethylene Glycol)-Propionic Acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Mal-PEG3-acid 518044-40-1
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-27

518044-40-1, Maleimido-Tri(Ethylene Glycol)-Propionic AcidRelated Search:

Mal-PEG4-Acid Mal-PEG1-NHS ester alpha-MaleiMidopropionyl-oMega-succiniMidyl-6(ethylene glycol) Mal-PEG2-amine Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester 3,4-Dibromo-Mal-PEG2-Amine Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid Mal-Amido-PEG4-acid

  • 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid
  • Mal-PEG3-acid
  • Maleimide-PEG3-CH2CH2COOH
  • Mal-PEG3-COOH
  • Mal-PEG3-CH2CH2COOH
  • Maleimido-Tri(Ethylene Glycol)-Propionic Acid
  • 3-(2-(2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid
  • Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-
  • 3-(2,5-dioxopyrrol-1-yl)-5-hydroxy-2,2-bis(2-hydroxyethyl)pentanoic acid
  • Mai-PEG3-acid
  • Mal-PEG3-CH2CH2COOH/Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-
  • Mal-PEG3-C2-COOH
  • 3-[2-[2-[2-(2,5-Dioxo-2,5-dihydro-1-pyrrolyl)ethoxy]ethoxy]ethoxy]propanoic Acid
  • 518044-40-1
  • C13H19NO7
  • peg

    • Cleavable

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