Histamine dihydrochloride

Product Name: Histamine dihydrochloride
CAS No.: 56-92-8
Chemical Name: Histamine dihydrochloride
Synonyms: HISTAMINE 2HCL;HistaMine dihdrochloride;Ceplene;Peremin;OCHLORIDE;Histamine HCI;HistaMine dihy;HISTAMINE DIHCL;histaMine (HCl)2;HistaMine Chloride
CBNumber: CB5183827
Molecular Formula: C5H11Cl2N3
Formula Weight: 184.07
MOL File: 56-92-8.mol

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Histamine dihydrochloride Property

Melting point:: 249-252 °C(lit.)
storage temp.: 2-8°C
solubility: H₂O: 0.1 g/mL, clear, colorless
form: powder
color: white to off-white
Water Solubility: SOLUBLE
Merck: 14,4719
BRN: 3624116
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: PPZMYIBUHIPZOS-UHFFFAOYSA-N
CAS DataBase Reference: 56-92-8(CAS DataBase Reference)
EPA Substance Registry System: 1H-Imidazole-4-ethanamine, dihydrochloride (56-92-8)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-42/43-42-22
Safety Statements: 22-26-36/37/39-45-37-36/37
RIDADR: 3335
WGK Germany: 2
RTECS: MS1575000
F: 1-8-9
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29332900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53300
Product name: Histamine dihydrochloride
Purity: ≥99.0% (AT)
Packaging: 1g
Price: $20.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1309009
Product name: Histamine dihydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 250mg
Price: $436
Updated: 2024/03/01

TCI Chemical

Product number: H0146
Product name: Histamine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $15
Updated: 2021/12/16

TCI Chemical

Product number: H0146
Product name: Histamine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $39
Updated: 2021/12/16

Alfa Aesar

Product number: L09198
Product name: Histamine dihydrochloride, 98+%
Packaging: 5g
Price: $55.1
Updated: 2024/03/01

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Histamine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Present in most mammalian tissues; primarily stored in mast cells and basophils. Exhibits multiple biological effects through at least 3 specific receptors. Induces bronchoconstriction and vasodilation; stimulates gastric acid secretion; and acts as a neurotransmitter.

Uses

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. It is a potent vasodilator and endogenous histamine receptor agonist.

Uses

Histamine dihydrochloride has been used:

as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
to determine its level in fish using HPLC (high performance liquid chromatography)
to assess the tracheal response to antigens in guinea-pigs

General Description

Histamine Dihydrochloride is a derivative of histamine, which is implicated in tumor cell apoptosis and prevents the relapse of acute myeloid leukemia in patients. It prevents the formation of ROS (reactive oxygen species) and inhibits the activation of T cells and natural killer cells.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Endogenous agonist at histamine receptors (H 1-4 ). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo .

Biochem/physiol Actions

Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor.

storage

Room temperature (desiccate)

Purification Methods

The dihydrochloride crystallises from aqueous EtOH. The phosphate (2H3PO4) [51-74-1] has m 132-133o (from H2O). [Beilstein 25 III/IV 2049.]

Histamine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Histamine dihydrochloride Suppliers

Austria 1 Belgium 6 Brazil 1 Canada 5 China 382 Czech Republic 2 Europe 4 France 3 Germany 10 India 26 Japan 6 Russia 1 South Korea 1 Spain 2 Switzerland 7 The Netherlands 3 United Kingdom 26 United States 81 Global 567

Melrob Ltd (part of Nordmann)

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View Lastest Price from Histamine dihydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Histamine dihydrochloride 56-92-8
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-04

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Histamine dihydrochloride 56-92-8
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 99.0%min BR
Supply Ability: 10000G
Release date: 2021-08-23

Hebei Dangtong Import and export Co LTD

Product: Histamine dihydrochloride 56-92-8
Price: US $260.00-200.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 500 ton
Release date: 2023-09-14

56-92-8, Histamine dihydrochlorideRelated Search:

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Histamine Dinydrochloride

2-(3H-Imidazol-4-yl)ethanamine dihydrochloride

Histamine dihydrochloride, 98%, a histamine receptor agonist

bichlorhydrated’histamine

edihydrochlorideAvailablefrom1kgto100kg.

histaminedichloride

OCHLORIDE

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HISTAMINE DIHCL

HISTAMINE DIHYDROCHLORIDE

HISTAMINI DIHYDROCHLORIDUM

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2-(4-IMIDAZOLYL)ETHYLAMINE DIHYDROCHLORIDE

Ceplene

Peremin

2-(1H-Imidazole-5-yl)ethanamine·dihydrochloride

Histamine Dihydrochloride (250 mg)

2-(1H-iMidazol-4-yl)ethan-1-aMine dihydrochloride

HistaMine dihydrochloride, 99% 25GR

HistaMine dihydrochloride, 99% 5GR

4-(2-AMinoethyl)iMidazole Dihydrochloride

HistaMine Chloride

HistaMinediiuM Dichloride

Histamine dihydrochloride,99%

HistaMine dihdrochloride

histaMine (HCl)2

Histamine dihydrochloride, 2-(1H-Imidazol-4-yl)ethylamine dihydrochloride

1H-Imidazole-5-ethanamine, hydrochloride (1:2)

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HistaMine dihy

Histamine dihydrochL

Histamine dihydrochloride, 98%, Histamine Receptor agonist

Histamine dihydrochloride 97%

HistamineDihydrochloride&gt

Histamine Dihydrochloride Standard

Histamine dihydrochloride CRS

Histamine dihydrochloride USP/EP/BP

Histamine dihydrochlorider