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ChemicalBook > CAS DataBase List > Ethyl 6-bromoindole-2-carboxylate

Ethyl 6-bromoindole-2-carboxylate

Application
Product Name
Ethyl 6-bromoindole-2-carboxylate
CAS No.
103858-53-3
Chemical Name
Ethyl 6-bromoindole-2-carboxylate
Synonyms
6-Br-ICA-OEt;SPECS AR-437/43285096;6-BROMO-2-CARBETHOXYINDOLE;6-bromoindole-2-carboxylate;6-6-BROMO-2-INDOLECARBOXYLIC;6-Bromo-2- carboethoxyindole;Ethyl 6-bromoindole-2-carboxylat;ETHYL 6-BROMOINDOLE-2-CARBOXYLATE;Methyl 6-bromoindole-2-carboxyate;ethyl 6-broMo-1H-indol-2-carboxylate
CBNumber
CB5196593
Molecular Formula
C11H10BrNO2
Formula Weight
268.11
MOL File
103858-53-3.mol
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Ethyl 6-bromoindole-2-carboxylate Property

Melting point:
178-180 °C
Boiling point:
394.7±22.0 °C(Predicted)
Density 
1.554±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in acetone.
form 
Crystalline Powder
pka
14.08±0.30(Predicted)
color 
White
InChI
InChI=1S/C11H10BrNO2/c1-2-15-11(14)10-5-7-3-4-8(12)6-9(7)13-10/h3-6,13H,2H2,1H3
InChIKey
FVMZWWFKRMBNSZ-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC(Br)=C2)C=C1C(OCC)=O
CAS DataBase Reference
103858-53-3(CAS DataBase Reference)
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Safety

Risk Statements 
20/21/22
Safety Statements 
36/37
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E900863
Product name
Ethyl6-bromo-1H-indole-2-carboxylate
Packaging
100mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
3455BB
Product name
Ethyl6-bromo-1H-indole-2-carboxylate
Packaging
25g
Price
$654
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-9-46
Product name
Ethyl 6-bromo-1H-indole-2-carboxylate
Packaging
10g
Price
$272
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0043742
Product name
ETHYL 6-BROMO-1H-INDOLE-2-CARBOXYLATE
Purity
95.00%
Packaging
1G
Price
$722.8
Updated
2021/12/16
Matrix Scientific
Product number
046758
Product name
Ethyl 6-bromo-1H-indole-2-carboxylate
Purity
>95%
Packaging
500mg
Price
$35
Updated
2021/12/16
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Ethyl 6-bromoindole-2-carboxylate Chemical Properties,Usage,Production

Application

Ethyl 6-bromo-2-indolecarboxylate can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development and chemical production processes.

Chemical Properties

White solid

Synthesis

In a 250mL three-necked flask, add 80mL of ethanol and 7.2g (40mmol) of 6-bromo-2-indolecarboxylic acid, slowly drop 1.0mL of concentrated sulfuric acid at room temperature and reflux for 30h (TLC tracking). After the reaction, concentrate to 30mL and pour into 60mL of water, extract twice with 20mL of ether, wash the ether layer once with 5% sodium carbonate solution, and then wash with water until neutral, dry with anhydrous magnesium sulfate, and evaporate the ether to obtain 7.7g of yellow to brown powder Ethyl 6-bromoindole-2-carboxylate, with a yield of 92.3%.

References

[1] Patent: KR101741956, 2017, B1. Location in patent: Paragraph 0685; 0690-0692

Ethyl 6-bromoindole-2-carboxylate Preparation Products And Raw materials

Raw materials

Xylene Hexane Sodium azide Ethanol Acetone Sodium Ammonium chloride Dichloromethane 2,5-Di-tert-butylhydroquinone 4-Bromobenzaldehyde Ethyl chloroacetate

Preparation Products

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View Lastest Price from Ethyl 6-bromoindole-2-carboxylate manufacturers

Career Henan Chemical Co
Product
Ethyl 6-bromoindole-2-carboxylate 103858-53-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-26

103858-53-3, Ethyl 6-bromoindole-2-carboxylateRelated Search:

Indole-3-acetic acid Diethyl 1,3-acetonedicarboxylate Indole-2-carboxylic acid Tris(trimethylsilyl)phosphate Ethylparaben Indole-3-butyric acid Ethanol Indometacin 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester Ethyl acetate Ethyl bromodifluoroacetate Ethyl bromoacetate ISOXADIFEN-ETHYL 6-Bromo-1H-indole 2-Ethoxyethanol RESMETHRIN 6-Bromoindole-2-carboxylic acid Trinexapac-ethyl

  • 6-BROMOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
  • 6-BROMO-2-CARBETHOXYINDOLE
  • ETHYL 6-BROMOINDOLE-2-CARBOXYLATE
  • SPECS AR-437/43285096
  • 6-BROMO-2-INDOLECARBOXYLIC METHYL ESTER
  • 6-6-BROMO-2-INDOLECARBOXYLIC
  • 6-6-BROMO-2-INDOLECARBOXYLICMETHYLESTER
  • 6-Br-ICA-OEt
  • ethyl 6-bromo-1H-indole-2-carboxylate
  • 6-Bromoindole-2-carboxylic acid methyl ester
  • Ethyl 6-bromoindole-2-carboxylate ,97%
  • 6-Bromo-2-(ethoxylcarbonyl)-1H-indole
  • ethyl 6-broMo-1H-indol-2-carboxylate
  • 6-BroMo-2-Indolecarboxylic ethyl ester
  • 1H-Indole-2-carboxylic acid, 6-broMo-, ethyl ester
  • Methyl 6-broMoindole-2-carboxylate, 97%
  • Ethyl 6-bromoindole-2-carboxylat
  • Methyl 6-bromoindole-2-carboxyate
  • 6-Bromo-2- carboethoxyindole
  • Ethyl 6-Bromoindole-2-carboxylate≥ 98.5% (HPLC)
  • Ethyl 6-bromo-1H-indole-2-carboxylate 98%
  • 6-Bromo-1H-indole-2-carboxylic acid ethyl ester
  • Methyl6-bromoindole-2-carboxylate,97%
  • 6-bromoindole-2-carboxylate
  • 1H-Indole-2-carboxylic acid, 6-bromo-, ethyl ester (9CI, ACI)
  • 6-bromo-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI)
  • 103858-53-3
  • 327089-59-3
  • Indoles
  • Indole/indoline/oxindole