ChemicalBook > CAS DataBase List > 2,2'-Dithiodipyridine

2,2'-Dithiodipyridine

Product Name
2,2'-Dithiodipyridine
CAS No.
2127-03-9
Chemical Name
2,2'-Dithiodipyridine
Synonyms
1,2-Di(pyridin-2-yl)disulfane;Aldrithiol;2-Aldrithiol;2-PDS;Dithiodipyridine;ALDRITHIOL-2;Dipyridyldisulfide;2-Pyridyl disulfide;2,2'-DIPYRIDYL DISULFIDE;1,2-Bis(2-pyridinyl) Disulfide
CBNumber
CB5200205
Molecular Formula
C10H8N2S2
Formula Weight
220.31
MOL File
2127-03-9.mol
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2,2'-Dithiodipyridine Property

Melting point:
56-58 °C(lit.)
Boiling point:
356.1±17.0 °C(Predicted)
Density 
1.3078 (rough estimate)
refractive index 
1.5500 (estimate)
Flash point:
210 °C
storage temp. 
2-8°C
solubility 
methanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow
form 
powder
pka
1.52±0.19(Predicted)
color 
Clear colorless to yellow to tan
Water Solubility 
5 g/L (20 ºC)
BRN 
154629
InChIKey
HAXFWIACAGNFHA-UHFFFAOYSA-N
LogP
2.530 (est)
CAS DataBase Reference
2127-03-9(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 2,2'-dithiobis-(2127-03-9)
EPA Substance Registry System
Pyridine, 2,2'-dithiobis- (2127-03-9)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-37-20/22
Safety Statements 
36/37/39-37/39-25-22-36-26
RIDADR 
UN 3335
WGK Germany 
3
F 
10-23
Autoignition Temperature
340 °C
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
143049
Product name
Aldrithiol?-2
Purity
98%
Packaging
1g
Price
$67.2
Updated
2024/03/01
Sigma-Aldrich
Product number
8.41109
Product name
2,2′-Dipyridyl disulfide
Purity
for synthesis
Packaging
5G
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
143049
Product name
Aldrithiol?-2
Purity
98%
Packaging
5g
Price
$128
Updated
2024/03/01
TCI Chemical
Product number
D1114
Product name
2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
D1114
Product name
2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$162
Updated
2024/03/01
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2,2'-Dithiodipyridine Chemical Properties,Usage,Production

Chemical Properties

white to yellowish crystalline powder

Uses

2,2'-Dipyridyl disulfide is a useful reagent for determination of sulfhydryl groups, preparation of amino acid active esters and the thio esters of phosphoric acid. It acts as a peptide coupling reagent and as an oxidizing agent. It is also used for the activation of glycosides.

Uses

2,2'-Dipyridyldisulfide, sometimes known as DPS, is used for preparing thiols and activating or protecting carboxylic acid with triphenylphosphine.

Uses

2,2'-Dithiodipyridine was used in the synthesis of adenosine-5′-phosphoimidazolide. It was employed with PPh3 as a condensing agent in the amidation of carboxylic acid enantiomers for HPLC separation.

Definition

ChEBI: Aldrithiol is a member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols. It has a role as an oxidising agent. It is an organic disulfide and a member of pyridines.

General Description

2,2'-Dithiodipyridine is a nucleocapsid zinc finger targeting compound and can abrogate the infectivity of human immunodeficiency virus type-1 virions. It is a thiol reagent.

Biochem/physiol Actions

2,2′-Dithiodipyridine mediates inter-unit disulfide cross-linking. It interacts with carbon nucleophiles to yield thiopyridyl derivatives.

Purification Methods

Recrystallise the disulfide H2O from *C6H6/pet ether (6:7), ligroin or *C6H6. The picrate has m 119o (from EtOH). [Walter et al. Justus Liebigs Ann Chem 695 7785 1966, Marckwald et al. Chem Ber 33 1556 1900, Brocklehurst & Little Biochem J 133 67,78 1973, Beilstein 21 III/IV 48.] It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 2-mercaptopyridine anion, thereby shifting the from 340nm (of the disulfide) to 268nm (of the anion) at pH 9, or 278nm in H2O. (Compare

2,2'-Dithiodipyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Finasteride
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2,2'-Dithiodipyridine Suppliers

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View Lastest Price from 2,2'-Dithiodipyridine manufacturers

Moxin Chemicals
Product
Vonoprazan Impurity 103 2127-03-9
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
1000000
Release date
2024-12-31
Baoji Guokang Bio-Technology Co., Ltd.
Product
2,2'-Dithiodipyridine 2127-03-9
Price
US $0.00/GK
Min. Order
1GK
Purity
98%
Supply Ability
1-10mt
Release date
2021-06-02
Hebei Weibang Biotechnology Co., Ltd
Product
2,2'-Dithiodipyridine 2127-03-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

2127-03-9, 2,2'-Dithiodipyridine Related Search:

2,5-PYRIDINEDICARBOXYLIC ACID Diallyldisulfide Dimethyl disulfide THIODIGLYCOLIC ACID 2,2'-Bipyridine Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Pyridine Dibenzyl disulfide 2,6-Lutidine Allicin 2,2'-DITHIOBIS(5-NITROPYRIDINE) 6,6'-DITHIODINICOTINIC ACID Bispyrithione 4,4'-DITHIODIPYRIDINE,4,4Dipyridyldisulfide-(4,4dithiodipyridine) GGKPDLRPCHPPCHYIPRPKPR 2,2'-Dithiodipyridine 4,4'-DIPYRIDYL DISULPHIDE, (4,4'-DITHIODIPYRIDINE) DI[5-(TRIFLUOROMETHYL)-2-PYRIDYL] DISULFIDE

  • NSC 94055
  • 1,2-Di(pyridin-2-yl)disulfane
  • 2,2'-Disulphanediyldipyridine, 2,2'-Dithiodipyridine
  • Di(pyridin-2-yl) disulphide
  • Aldrithiol(TM)-2 98%
  • 1,2-Di(pyridin-2-yl)disulfide
  • 2-(2-Pyridinyldisulfanyl)pyridine
  • 2,2'-Dipyridinyl disulfide
  • 2,2'-Dithiobis(pyridine)
  • 2,2'-Dithiopyridine
  • 2-Dipyridyl disulfide
  • 2PDS
  • 2-Pyridyl disulfide
  • Aldrithol-2
  • 2,2'-Dithiodipyridine, >=99%
  • Bis(pyridin-2-yl) disulfide
  • Aldrithiol
  • 2,2μ-Dipyridyl disulfide, 2,2μ-Dithiodipyridine
  • Aldritiol
  • Di(2-pyridyl) persulfide
  • Dithiodipyridine
  • 2,2'-Dithiodipyridine,98%
  • 2,2'-Dithiodipyridin
  • Bis(pyridin-2-yl) disulphide
  • 2,2'- Dipyridil disulfide
  • 2-(pyridin-2-yldisulfanyl)pyridine
  • 1,2-Bis(2-pyridinyl) Disulfide
  • 2,2'-Bipyridyldisulfide
  • 2-Aldrithiol
  • 1,2-Di(pyridin-2-yl
  • Bis(2-pyridinyl) disulfide
  • Bis(2-pyridyl) disulfide
  • Di-2-Pyridyl disulfide
  • Nsc 677438
  • Pyridine, 2,2'-dithiodi-
  • ALDRITHIOL-2
  • ALDRITHIOL(TM)-2
  • 2,2'-DITHIODIPYRIDINE
  • 2,2'-DIPYRIDYL DISULFIDE
  • 2,2'-DIPYRIDYL DISULPHIDE
  • 2-(PYRIDIN-2-YLDITHIO)PYRIDINE
  • 2-PYRIDINYL DISULFIDE
  • 2-PDS
  • 2,2'-Dipyridyl Disulfide [for Peptide Synthesis]
  • Dipyridyldisulfide
  • Pyridine, 2,2-dithiobis-
  • 2,2''-DIPYRIDYL DISULFIDE 98+%
  • Di(pyridin-2-yl) disulfide
  • 2,2'-Dipyridyl disulfide, 98%, for synthesis
  • 2,2'-DipyridylDisulfide[forPeptideSynthesis]&gt
  • 2,2'-DIPYRIDYL DISULFIDE FOR SYNTHESIS
  • 2,2'-Dithiodipyridine ISO 9001：2015 REACH
  • 2-(2-Pyridyldisulfanyl)pyridine
  • 9-[(3aS,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-3H-purin-6-one
  • 2,2'-Dithiodipyridine
  • 2,2'-Dipyridyl disulfide
  • 2,2'-Dipyridyl disulfide|||OPSS|||Aldrithiol 2|||Orthopyridyl disulfide
  • 2127-03-9