Ethyl 4-methoxycinnamate

Product Name: Ethyl 4-methoxycinnamate
CAS No.: 24393-56-4
Chemical Name: Ethyl 4-methoxycinnamate
Synonyms: ETHYL P-METHOXYCINNAMATE;4-METHOXYCINNAMIC ACID ETHYL ESTER;Ethyl trans-4-methoxycinnamate;(E)-Ethyl p-methoxycinnamate;ethyl (E)-4-methoxycinnamate;ETHYL 3-(4-METHOXYPHENYL)ACRYLATE;EPMC;RARECHEM AL BI 0241;Ethyl 4-Methoxyciamate;Ethyl 4-methoxycinmate
CBNumber: CB5205790
Molecular Formula: C12H14O3
Formula Weight: 206.24
MOL File: 24393-56-4.mol

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Ethyl 4-methoxycinnamate Property

Melting point:: 49°C
Boiling point:: 187 °C / 15mmHg
Density: 1.080±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Off-White
Water Solubility: insoluble in water
BRN: 2210033
LogP: 2.650 (est)
NIST Chemistry Reference: Ethyl p-methoxycinnamate(24393-56-4)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-24/25
WGK Germany: 3
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 42479
Product name: Ethyl trans-4-methoxycinnamate
Purity: analytical standard
Packaging: 10mg
Price: $207
Updated: 2022/05/15

TCI Chemical

Product number: M1204
Product name: Ethyl 4-Methoxycinnamate
Purity: >98.0%(GC)
Packaging: 5g
Price: $80
Updated: 2024/03/01

TCI Chemical

Product number: M1204
Product name: Ethyl 4-Methoxycinnamate
Purity: >98.0%(GC)
Packaging: 25g
Price: $228
Updated: 2024/03/01

Cayman Chemical

Product number: 11740
Product name: Ethyl p-methoxycinnamate
Packaging: 50mg
Price: $31
Updated: 2023/06/20

Cayman Chemical

Product number: 11740
Product name: Ethyl p-methoxycinnamate
Packaging: 100mg
Price: $55
Updated: 2023/06/20

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Ethyl 4-methoxycinnamate Chemical Properties,Usage,Production

Chemical Properties

White crystalline, soluble in methanol, ethanol, DMSO and other organic solvents, derived from cinnamon.

Uses

Ethyl 4-methoxycinnamate is an derivative of 4-methoxycinnamic acid, an antihyperglycemic/hypoglycemic agent that works by stimulating insulin secretion from pancreas and could be developed into a new potential for therapeutic agent used in type 2 diabetic patients.

Preparation

Ethyl 4-methoxycinnamate synthesis: 4-Methoxycinnamic Acid (0.60 g, 3.36 mmol) was dissolved in 10 mL of dry N,N-dimethylformamide (DMF) in a 25-mL, roundbottomed flask. Cesium carbonate (1.65 g, 5.06 mmol) was added followed by iodoethane (1.0 mL, 12.5 mmol). The flask was capped (rubber septum) and the heterogeneous mixture stirred vigorously at 50 °C for one hour. After this time, HCl (1.0 M, 4.0 mL) was added to quench the reaction. The liquid was decanted from any remaining solid and extracted with 3 : 1 hexanes/ethyl acetate (2 x 10 mL). The organic layer was washed with brine (20 mL), dried with MgSO4, filtered, and solvent removed. The remaining oil solidified on standing to form colorless prisms.

Synthesis of ethyl 4-methoxycinnamate

General Description

Ethyl p-methoxycinnamate (EPMC) is a natural product found in K. galanga and C. zedoaria extracts with anti-inflammatory, antiangiogenic, antifungal, larvicidal, and analgesic activities. It inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 μM, respectively) and reduces IL-1 and TNF-α production in vivo. EPMC inhibits granuloma tissue formation and acts as an analgesic, delaying tail flick time, in a dose-dependent manner in rats. It inhibits blood vessel growth in rat aortic explants (IC50 = 91.9 μg/ml). EPMC (<10 μg/ml) also reduces growth of T. rubrum, A. niger, S. cerevisiae, and E. floccosum and is larvicidal (LC50 = 53.64 ppm) against Ae. aegypti.

Ethyl 4-methoxycinnamate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl 4-methoxycinnamate Suppliers

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EMMX Biotechnology LLC

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View Lastest Price from Ethyl 4-methoxycinnamate manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: Ethyl 4-methoxycinnamate 24393-56-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-13

Hebei Kingfiner Technology Development Co.Ltd

Product: Ethyl 4-methoxycinnamate 24393-56-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000kg
Release date: 2023-11-23

Hebei Yime New Material Technology Co., Ltd.

Product: Ethyl 4-Methoxycinnamate 24393-56-4
Price: US $150.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2022-01-22

24393-56-4, Ethyl 4-methoxycinnamateRelated Search:

Ethylparaben Ethanol Ethyl formate Ethyl acetate 3,4-Dimethoxycinnamonitrile Ethyl cinnamate ISOXADIFEN-ETHYL Ethyl 4-methylcinnamate 4-(Trifluoromethyl)cinnamic acid Ethyl 4-methoxybenzoate Ethyl acrylate Ethyl oleate Acrylic acid 4-Bromocinnamic acid 4-Methoxycinnamic acid Octyl 4-methoxycinnamate Ethyl pyruvate Ethyl cyanoacetate

4-METHOXYCINNAMIC ACID ETHYL ESTER

3-(4-METHOXYPHENYL)ACRYLIC ACID ETHYL ESTER

ETHYL P-METHOXYCINNAMATE

ETHYL 3-(4-METHOXYPHENYL)ACRYLATE

ETHYL 4-METHOXYCINNAMATE

RARECHEM AL BI 0241

Methoxycinnamicacidethylester

4-METHOXYCINNAMIC ACID ETHYL ESTER 98+%

P-methoxyl ethyl cinnamate

4-Methoxycinnamic Acid Ethyl Ester Ethyl 3-(4-Methoxyphenyl)acrylate 3-(4-Methoxyphenyl)acrylic Acid Ethyl Ester

ParaMethoxyethylcinnaMate

1-(tert-butoxycarbonyl)-4-(4-Methoxyphenyl)pyrrolidine-3-carboxylic acid

(E)-Ethyl 3-(4-Methoxyphenyl)acrylate

Ethyl trans-4-methoxycinnamate

Ethyl 4-Methoxyciamate

(E)-3-(4-Methoxyphenyl)-2-propenoic acid ethyl ester

Ethyl (E)-3-(4-methoxyphenyl)-2-propenoate

trans-4-Methoxycinnamic acid ethyl ester

Ethyl trans-p-methoxycinnamate

Ethyl 4-methoxycinmate

(E)-Ethyl p-methoxycinnamate

trans-p-Methoxycinnamic acid ethyl ester

Ethyl4-Methoxycinnamate&gt

EPMC

Ethyl para-methoxycinnamate

2-Propenoic acid, 3-(4-methoxyphenyl)-, ethyl ester, (2E)-

Ethyl 4-methoxycinnamate USP/EP/BP

Ferulic acid,ethyl ester,4-Methoxycinnamic Acid Ethyl Ester,Ethyl trans-4-methoxycinnamate,ethyl p-methoxycinnamate,3-(4-Methoxyphenyl)acrylic Acid

ethyl (E)-4-methoxycinnamate

Ethyl trans-4-methoxycinnamate-d3

trans-p-Methoxycinnamic acid ethyl ester-RM

24393-56-4

Cinnamic acid