Sodium carboxymethyl cellulose
description Product Features Uses Synthesis Usage Instruction- Product Name
- Sodium carboxymethyl cellulose
- CAS No.
- 9004-32-4
- Chemical Name
- Sodium carboxymethyl cellulose
- Synonyms
- Carboxymethyl cellulose;CMC-Na;cellulose gum;carmellose sodium;b10;carbo;Carboxyl Methyl Cellulose sodium;cmc2;Color Speckles;Cellex
- CBNumber
- CB5209844
- Molecular Formula
- C6H7O2(OH)2CH2COONa
- Formula Weight
- 0
- MOL File
- 9004-32-4.mol
Sodium carboxymethyl cellulose Property
- Melting point:
- 274 °C (dec.)
- Density
- 1,6 g/cm3
- FEMA
- 2239 | CARBOXYMETHYLCELLULOSE
- storage temp.
- room temp
- solubility
- H2O: 20 mg/mL, soluble
- form
- low viscosity
- pka
- 4.30(at 25℃)
- color
- White to light yellow
- Odor
- Odorless
- PH Range
- 6.5 - 8.5
- PH
- pH (10g/l, 25℃) 6.0～8.0
- Water Solubility
- soluble
- Merck
- 14,1829
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- EPA Substance Registry System
- Sodium carboxymethyl cellulose (9004-32-4)
N-Bromosuccinimide Price
- Product number
- PHR2726
- Product name
- Carboxymethylcellulose Sodium
- Purity
- PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer
- Packaging
- 2G
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 17851-M
- Product name
- Aquacide II
- Packaging
- 17851-1KG
- Price
- $124
- Updated
- 2024/03/01
- Product number
- 17851-M
- Product name
- Aquacide II
- Packaging
- 17851-5KG
- Price
- $513
- Updated
- 2024/03/01
- Product number
- 1096553
- Product name
- Carboxymethylcellulose sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 1.5g
- Price
- $491
- Updated
- 2024/03/01
- Product number
- 17851-M
- Product name
- Aquacide II
- Packaging
- 1kg
- Price
- $103
- Updated
- 2022/05/15
Sodium carboxymethyl cellulose Chemical Properties,Usage,Production
description
Sodium carboxymethyl cellulose(9004-32-4) is a water-soluble polymer. As a solution in water, it has thixotropic properties. It is useful in helping to hold the components of pyrotechnic compositions in aqucous suspension (e.g., in the making of black match). It is also an especially effective binder that can be used in small amounts in compositions, where the binder can intcrfere with the intended effect (e.g., in strobe compositions). However, its sodium content obviously precludes its use in most color compositions. Sodium carboxymethyl-cellulose is manufactured from cellulose by various proccsses that replacc some of the hy drogen atoms in the hydroxyl[OH] groups of the cellulose molecule with acidic carboxymethyl [-CH2CO.OH] groups，which are neutralized to form the corresponding sodium salt. Sodium carboxymethyl cellulose is white when pure; industrial grade material may be grayish-white or cream granules or powder.
Product Features
Carboxymethyl cellulose (CMC) is tackifier, at room temperature, it is non-toxic tasteless white flocculent powder, it is stable and soluble in water, aqueous solution is neutral or alkaline transparent viscous liquid, it is soluble in other water-soluble gums and resins, it is insoluble in organic solvents such as ethanol. Carboxymethyl cellulose is the substituted product of cellulosic carboxymethyl group. According to their molecular weight or degree of substitution, it can be completely dissolved or insoluble polymer, the latter can be used as the weak acid cation of exchanger to separate neutral or basic proteins.
Carboxymethyl cellulose can form highly viscous colloidal solution with adhesive, thickening, flowing, emulsifying, shaping, water, protective colloid, film forming, acid, salt, suspensions and other characteristics, and it is physiologically harmless, so it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.
Uses
Sodium carboxymethyl cellulose (CMC,9004-32-4) is frequently called simply carboxymethyl cellulose and also known as cellulose gum. It is derived from purified cellulose from cotton and wood pulp. It is a water dispersible sodium salt of carboxy-methyl ether of cellulose that forms a clear colloidal solution. It is a hygroscopic material that has the ability to absorb more than 50% of water at high humidity. It is also a natural polymeric derivative that can be used in detergents, food and textile industries.
CMC is one of the most important products of cellulose ethers, which are formed by natural cellulose modification as a kind of cellulose derivate with an ether structure. Due to the fact that the acid form of CMC has poor water solubility, it is usually preserved as sodium carboxymethylcellulose, which is widely used in many industries and regarded as monosodium glutamate in industry.
CMC is used in cigarette adhesive, fabric sizing, footwear paste meal, home slimy. It is used in interior painting architectural, building lines melamine, thickening mortar, concrete enhancement. It is used in refractory fiber, ceramic production molding bond. It is used in oil drilling, exploration address slurry thickening, reducing water loss, quality paper surface sizing. It can be used as soap and washing powder detergent active additives, as well as other industrial production on the dispersion, emulsification, stability, suspension, film, paper, polishing and the like. Quality product can be used for toothpaste, medicine, food and other industrial sectors.
Synthesis
Sodium carboxymethyl cellulose is formed when cellulose reacts with mono chloroacetic acid or its sodium salt under alkaline condition with presence of organic solvent, hydroxyl groups substituted by Sodium carboxymethyl groups in C2, C3 and C6 of glucose, which substitution slightly prevails at C2 position.
Generally, there are two steps in manufacturing process of sodium carboxymethyl cellulose, alkalinization and etherification.
Step 1: Alkalinization
Disperse the raw material cellulose pulp in alkali solution (generally sodium hydroxide, 5–50%) to obtain alkali cellulose.
Cell-OH+NaOH →Cell·O-Na+ +H2O
Step 2: Etherification
Etherification of alkali cellulose with sodium monochloroacetate (up to 30%) in an alcohol-water medium. The mixture of alkali cellulose and reagent is heated (50–75°C) and stirred during the process.
ClCH2COOH+NaOH→ClCH2COONa+H2O
Cell·O-Na+ +ClCH2COO- →Cell-OCH2COO-Na
The DS of the sodium CMC can be controlled by the reaction conditions and use of organic solvents (such as isopropanol).
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Usage Instruction
Use warm water or cold water when preparing the solution, and stir till it completely melts. The amout of added water depends on variety and the use of multiple requirements.
High viscosity sodium carboxymethyl cellulose (HV-CMC) is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water. It is reacted by the acid and fibrous cotton, it is mainly used for water-based drilling fluids tackifier, it has certain role of fluid loss, it has strong salt and temperature resistance especially.
Chemical Properties
Carboxymethylcellulose sodium occurs as a white to almost white, odorless, tasteless, granular powder. It is hygroscopic after drying.
Uses
cellulose gum (Carboxymethyl cellulose) is a thickener, binder, and emulsifier equivalent to cellulose fiber. It is resistant to bacterial decomposition and provides a product with uniform viscosity. It can prevent skin moisture loss by forming a film on the skin’s surface, and also help mask odor in a cosmetic product. Constituents are any of several fibrous substances consisting of the chief part of a plant’s cell walls (often extracted from wood pulp or cotton).
Uses
In drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes, as protective colloid in general. As stabilizer in foods. Pharmaceutic aid (suspending agent; tablet excipient; viscosity-increasing agent).
Uses
Carboxymethylcellulose sodium salt is used in drilling muds, in detergents as a soil-suspending agent, in resin emulsion paints, adhesives, printing inks, textile sizes and protective colloid. It acts as a stabilizer in foods. It is also employed in pharmaceuticals as a suspending agent and excipients for tablets. It is used as viscosity modifiers to stabilize the emulsions. It is used as a lubricant in artificial tears and it is used to characterize enzyme activity from endoglucanases.
Production Methods
Alkali cellulose is prepared by steeping cellulose obtained from wood pulp or cotton fibers in sodium hydroxide solution. The alkaline cellulose is then reacted with sodium monochloroacetate to produce carboxymethylcellulose sodium. Sodium chloride and sodium glycolate are obtained as by-products of this etherification.
Definition
A semisynthetic, water-soluble polymer in which CH 2 COOH groups are substituted on the glucose units of the cellulose chain through an ether link- age. Mw ranges from 21,000 to 500,000. Since the reaction occurs in an alkaline medium, the prod- uct is the sodium salt of the carboxylic acid R-O- CH 2 COONa.
brand name
Celluvisc (Allergan); Refresh Plus, Cellufresh Formula (Allergan).
General Description
Sodium carboxymethyl cellulose (CMC) belongs to the class of anionic linear structured cellulose. Its components consist of polysaccharide composed of fibrous tissues of plants. It is a water soluble polymer which can be used as a polyelectrolyte cellulose derivative.
Pharmaceutical Applications
Sodium carboxymethyl cellulose (NaCMC) is the sodium salt of carboxymethyl cellulose, an anionic derivative.It is widely used in oral and topical pharmaceutical formulations, primarily for its viscosity-increasing properties. Viscous aqueous solutions are used to suspend powders intended for either topical application or oral and parenteral administration. Carboxymethylcellulose sodium may also be used as a tablet binder and disintegrant, and to stabilize emulsions.
Higher concentrations, usually 3–6%, of the medium-viscosity grade are used to produce gels that can be used as the base for applications and pastes; glycols are often included in such gels to prevent them drying out. Carboxymethylcellulose sodium is also used in self-adhesive ostomy, wound care, and dermatological patches as a muco-adhesive and to absorb wound exudate or transepidermal water and sweat. This muco-adhesive property is used in products designed to prevent post-surgical tissue adhesions; and to localize and modify the release kinetics of active ingredients applied to mucous membranes; and for bone repair. Encapsulation with carboxymethylcellulose sodium can affect drug protection and delivery. There have also been reports of its use as a cyto-protective agent.
Carboxymethylcellulose sodium is also used in cosmetics, toiletries, surgical prosthetics, and incontinence, personal hygiene, and food products.
Safety Profile
Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. It migrates to food from packagmg materials. When heated to decomposition it emits toxic fumes of NazO. See also POLYMERS, SOLUBLE.
Safety
Carboxymethylcellulose sodium is used in oral, topical, and some
parenteral formulations. It is also widely used in cosmetics,
toiletries, and food products, and is generally regarded as a
nontoxic and nonirritant material. However, oral consumption of
large amounts of carboxymethylcellulose sodium can have a
laxative effect; therapeutically, 4–10 g in daily divided doses of the
medium- and high-viscosity grades of carboxymethylcellulose
sodium have been used as bulk laxatives.
The WHO has not specified an acceptable daily intake for
carboxymethylcellulose sodium as a food additive since the levels
necessary to achieve a desired effect were not considered to be a
hazard to health. However, in animal studies, subcutaneous
administration of carboxymethylcellulose sodium has been found to
cause inflammation, and in some cases of repeated injection
fibrosarcomas have been found at the site of injection.
Hypersensitivity and anaphylactic reactions have occurred in
cattle and horses, which have been attributed to carboxymethylcellulose
sodium in parenteral formulations such as vaccines and
penicillins.
LD50 (guinea pig, oral): 16 g/kg
LD50 (rat, oral): 27 g/kg
storage
Carboxymethylcellulose sodium is a stable, though hygroscopic
material. Under high-humidity conditions, carboxymethylcellulose
sodium can absorb a large quantity (>50%) of water. In tablets, this
has been associated with a decrease in tablet hardness and an
increase in disintegration time.
Aqueous solutions are stable at pH 2–10; precipitation can occur
below pH 2, and solution viscosity decreases rapidly above pH 10.
Generally, solutions exhibit maximum viscosity and stability at pH
7–9.
Carboxymethylcellulose sodium may be sterilized in the dry state
by maintaining it at a temperature of 1608℃ for 1 hour. However,
this process results in a significant decrease in viscosity and some
deterioration in the properties of solutions prepared from the
sterilized material.
Aqueous solutions may similarly be sterilized by heating,
although this also results in some reduction in viscosity. After
autoclaving, viscosity is reduced by about 25%, but this reduction is
less marked than for solutions prepared from material sterilized in
the dry state. The extent of the reduction is dependent on the
molecular weight and degree of substitution; higher molecular
weight grades generally undergo a greater percentage reduction in
viscosity. Sterilization of solutions by gamma irradiation also
results in a reduction in viscosity.
Aqueous solutions stored for prolonged periods should contain
an antimicrobial preservative.
The bulk material should be stored in a well-closed container in a
cool, dry place.
Purification Methods
Dialyse it for 48hours against distilled water and freeze-dry if a solid is required.
Properties and Applications
|
TEST ITEMS |
SPECIFICATION |
|
|
CMC-LV |
CMC-HV |
|
|
Appearance |
Cream colored and free flowing powder |
Cream colored and free flowing powder |
|
Degree of Substitution |
0.6-0.9 |
0.6-0.9 |
|
pH |
6-9 |
6-9 |
|
Moisture % |
10% max |
10% max |
|
Sodium CMC content on dry basis |
70% min |
70% min |
|
Viscosity at 600RPM |
90 max in deionized water 10 max 4% salt water mud,API water loss |
30 max in deionized water 30 min in 4% salt water 30 min in 4% saturated salt water 10 max 4% salt water mud,API water loss |
Incompatibilities
Carboxymethylcellulose sodium is incompatible with strongly
acidic solutions and with the soluble salts of iron and some other
metals, such as aluminum, mercury, and zinc. It is also incompatible
with xanthan gum. Precipitation may occur at pH < 2, and also
when it is mixed with ethanol (95%).
Carboxymethylcellulose sodium forms complex coacervates
with gelatin and pectin. It also forms a complex with collagen
and is capable of precipitating certain positively charged proteins.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intraarticular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Sodium carboxymethyl cellulose Preparation Products And Raw materials
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View Lastest Price from Sodium carboxymethyl cellulose manufacturers
- Product
- Sodium carboxymethyl cellulose 9004-32-4
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-21
- Product
- Sodium carboxymethyl cellulose 9004-32-4
- Price
- US $46.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-13
- Product
- Sodium carboxymethyl cellulose 9004-32-4
- Price
- US $3.50/kg
- Min. Order
- 1kg
- Purity
- ≥99%
- Supply Ability
- 3000tons/month
- Release date
- 2024-08-17