ChemicalBook > CAS DataBase List > 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE

4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE

Product Name: 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
CAS No.: 33097-11-9
Chemical Name: 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE
Synonyms: ASISCHEM C51986;2-Aminomethylimidazoledihydrochloride;4,6-DICHLORO-2-(METHYLTHIO)-5-FORMYLPYRIMIDINE;2,4-Dichloro-5-formyl-2-(methylthio)pyrimidine;4,6-Dichloro-5-formyl-2-(methylthio)pyrimidine;4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARB;4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde;4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde;2-(Methylthio)-4,6-dichloropyriMidine-5-carboxaldehyde;4,6-Dichloro-2-(methylthio)-5-pyrimidinecarboxaldehyde
CBNumber: CB5225675
Molecular Formula: C6H4Cl2N2OS
Formula Weight: 223.08
MOL File: 33097-11-9.mol

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4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Property

Melting point:: 82-84°C
Boiling point:: 327.7±37.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Ether, Ethyl Acetate
form: Solid
pka: -6.47±0.39(Predicted)
color: Pale Yellow
InChI: InChI=1S/C6H4Cl2N2OS/c1-12-6-9-4(7)3(2-11)5(8)10-6/h2H,1H3
InChIKey: MRHGOAKYYORQGQ-UHFFFAOYSA-N
SMILES: C1(SC)=NC(Cl)=C(C=O)C(Cl)=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-43
Safety Statements: 36/37
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 759279
Product name: 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxaldehyde
Purity: 97%
Packaging: 1g
Price: $72
Updated: 2023/06/20

TRC

Product number: D435570
Product name: 4,6-Dichloro-2-(methylthio)-5-formylpyrimidine
Packaging: 10g
Price: $135
Updated: 2021/12/16

Matrix Scientific

Product number: 081710
Product name: 4,6-Dichloro-2-(methylthio)-pyrimidine-5-carbaldehyde
Purity: 97%
Packaging: 1g
Price: $48
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD09667
Product name: 2,4-Dichloro-5-formyl-2-(methylthio)pyrimidine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD09667
Product name: 2,4-Dichloro-5-formyl-2-(methylthio)pyrimidine
Packaging: 1g
Price: $105
Updated: 2021/12/16

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4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

4,6-Dichloro-2-(methylthio)-5-formylpyrimidine (cas# 33097-11-9) is a compound useful in organic synthesis.

Synthesis

1979-98-2

33097-11-9

The general procedure for the synthesis of 4,6-dichloro-2-methylthiopyrimidine-5-carbaldehyde from 4,6-dihydroxy-2-methylthiopyrimidine was as follows: the reaction system was cooled down to 0-10 °C and then slowly warmed up to room temperature. Subsequently, 6-hydroxy-2-(methylthio)-4(1H)-pyrimidinone (25 g, 0.16 mol) was added in batches. The reaction mixture was heated and reacted at 80 °C overnight. After completion of the reaction, the reaction mixture was concentrated under vacuum. The concentrated slurry residue was poured into ice and stirred continuously for about 2 hours, after which filtration was performed to obtain the crude product. The crude product was further purified by recrystallization with hexane to afford finally 4,6-dichloro-2-(methylthio)-5-pyrimidinecarboxaldehyde (21.3 g, 61% yield). The structure of the product was confirmed by 1H-NMR (CDCl3): δ 2.66 (s, 3H), 10.4 (s, 1H).

References

[1] Patent: WO2006/104889, 2006, A2. Location in patent: Page/Page column 113-114
[2] Patent: WO2007/147103, 2007, A2. Location in patent: Page/Page column 107-108

4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Sodium Phosphorus oxitrichloride Ethyl acetate Diethyl malonate PETROLEUM ETHER Iodomethane Thiourea

Preparation Products

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4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE Suppliers

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View Lastest Price from 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE manufacturers

Dideu Industries Group Limited

Product: 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 33097-11-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-14

Career Henan Chemical Co

Product: 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 33097-11-9
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-08

33097-11-9, 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDERelated Search:

4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 4-Chloro-5-methylpyrimidine 4-CHLORO-5-METHYL-2-METHYLSULFANYL-PYRIMIDINE 4,6-Dichloro-5-methylpyrimidine 4,6-Dichloro-5-pyrimidinecarbaldehyde 4-Chloro-6-methyl-2-(methylthio)pyrimidine 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE 4,6-Dichloropyrimidine 4-Chloro-2-methylthiopyrimidine 2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE

ASISCHEM C51986

4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE

4,6-DICHLORO-2-(METHYLTHIO)-5-FORMYLPYRIMIDINE

4,6-Dichloro-2-Methylsulfamylpyrimidine-5-Carboxaldehyde

2-Aminomethylimidazoledihydrochloride

4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde

4,6-Dichloro-2-(methylthio)-5-pyrimidinecarbaldehyde

4,6-Dichloro-2-(methylthio)-5-pyrimidinecarboxaldehyde

2,4-Dichloro-5-formyl-2-(methylthio)pyrimidine

2-(Methylthio)-4,6-dichloropyriMidine-5-carboxaldehyde

4,6-Dichloro-2-MethylsulfanylpyriMidine-5-carboxaldehyde

4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxaldehyde

4,6-Dichloro-5-formyl-2-(methylthio)pyrimidine

4,6-Dichloro-2-methylsulphanyl-pyrimidine-5-carbaldehyde

5-Pyrimidinecarboxaldehyde, 4,6-dichloro-2-(methylthio)-

4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH

4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE-5-CARB

4,6-DI CHLORO-2-METHYL SULPHONYL PYRIMIDINE-5-CARBAXALDEHYDE

33097-11-9

C6H4Cl2N2OS

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides

pyrimidine

Heterocycle-Pyrimidine series