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Fmoc-L-hydroxyproline

Product Name
Fmoc-L-hydroxyproline
CAS No.
88050-17-3
Chemical Name
Fmoc-L-hydroxyproline
Synonyms
G1-15;FMoc-Hyp;FMOC-HYP-OH;FMOC-L-HYP-OH;FMOC-HYP-OH 99%MIN;RARECHEM EM WB 0137;FMOC-HYP-OH (TRANS);FMOC-HYDROXYPROLINE;FMOC-TRANS-4-HYP-OH;FMOC-L-HYDROXYPROLINE
CBNumber
CB5230512
Molecular Formula
C20H19NO5
Formula Weight
353.37
MOL File
88050-17-3.mol
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Fmoc-L-hydroxyproline Property

Melting point:
189-193 °C
Boiling point:
595.5±50.0 °C(Predicted)
Density 
1.407±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
3.74±0.40(Predicted)
color 
White to off-white
optical activity
[α]20/D 60±2°, c = 1% in methanol
BRN 
4574378
InChI
InChI=1S/C20H19NO5/c22-12-9-18(19(23)24)21(10-12)20(25)26-11-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,12,17-18,22H,9-11H2,(H,23,24)/t12-,18+/m1/s1
InChIKey
GOUUPUICWUFXPM-XIKOKIGWSA-N
SMILES
N1(C(OCC2C3=C(C=CC=C3)C3=C2C=CC=C3)=O)C[C@H](O)C[C@H]1C(O)=O
CAS DataBase Reference
88050-17-3(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.52033
Product name
Fmoc-Hyp-OH
Purity
Novabiochem?
Packaging
5G
Price
$93.6
Updated
2025/07/31
Sigma-Aldrich
Product number
8.52033
Product name
Fmoc-Hyp-OH
Purity
Novabiochem?
Packaging
25g
Price
$372
Updated
2025/07/31
Sigma-Aldrich
Product number
47686
Product name
Fmoc-Hyp-OH
Purity
≥98.0% (sum of enantiomers, HPLC)
Packaging
5g
Price
$71.1
Updated
2025/07/31
TCI Chemical
Product number
F0899
Product name
Fmoc-Hyp-OH
Packaging
5G
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
F0899
Product name
Fmoc-Hyp-OH
Packaging
25G
Price
$122
Updated
2025/07/31
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Fmoc-L-hydroxyproline Chemical Properties,Usage,Production

Chemical Properties

Light brown solid

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

28920-43-6

51-35-4

88050-17-3

The general procedure for the synthesis of Fmoc-L-hydroxyproline from methyl 9-fluorenyl chloroformate and L-hydroxyproline is as follows: Example 2: Synthesis of (2S,4R)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid 1. Sodium bicarbonate (80 g) and water (400 ml) were added to a solution of tetrahydrofuran (THF, 200 ml) containing (2S,4R)-4-hydroxy-L-proline (100 g) at 25-30 °C. 2. A solution of 9-fluorenylmethoxycarbonyl (Fmoc) chloride (226 g) dissolved in 200 ml of THF was added slowly. 3. The reaction mixture was stirred continuously at 25-30°C for 10-12 hours until the reaction was complete. 4. Upon completion of the reaction, the reaction was terminated by the addition of an appropriate amount of water. 5. The reaction mixture was washed with diisopropyl ether (DIPE) and subsequently acidified with 1N hydrochloric acid. 6. The acidified mixture was continued to be stirred for 2-3 hours to promote precipitation of the product. 7. The solid product was collected by filtration to give 150 g of Fmoc-L-hydroxyproline as a white solid. Product Characterization: 1H NMR (300 MHz, DMSO-d6): δ 1.89-2.24 (m, 2H), 3.34-3.43 (m, 2H), 3.43-3.54 (m, 0.5H), 4.12-4.21 (m, 3H), 4.25 (s, 2H), 4.28-4.42 (m, 0.5H), 5.16 (brs, 1H) , 7.29-7.34 (m, 2H), 7.38-7.65 (m, 2H), 7.63-7.65 (m, 2H). Melting point: 188-190°C. Mass spectrum (M + H): 354.33.

References

[1] Tetrahedron Letters, 1994, vol. 35, # 51, p. 9509 - 9512
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 10, p. 1784 - 1787
[3] Patent: US9518048, 2016, B2. Location in patent: Page/Page column 24

Fmoc-L-hydroxyproline Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-L-hydroxyproline Suppliers

China 205 France 1 Germany 6 India 4 Japan 2 Switzerland 2 United Kingdom 7 United States 33 Global 260
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
Senn Chemicals AG
Tel
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Email
swiss@sennchem.com
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Switzerland
ProdList
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View Lastest Price from Fmoc-L-hydroxyproline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Fmoc-L-Hyp-OH 88050-17-3
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-26
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Fmoc-L-Hyp-OH 88050-17-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-12-07
Career Henan Chemical Co
Product
Fmoc-L-hydroxyproline 88050-17-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

88050-17-3, Fmoc-L-hydroxyprolineRelated Search:

cis-4-Hydroxy-L-proline L-Hydroxyproline N-Vinyl-2-pyrrolidone Fmoc-Phe-OH D-Proline Pyrrolidine Fmoc-Lys(Boc)-OH Boc-Hyp-OH Fmoc-Aib-OH N-Methyl-2-pyrrolidone 9-Fluorenylmethyl chloroformate CHLOROPHOSPHONAZO III Polyvinylpyrrolidone L-Proline L-PROLINE-(4-3H(N)) cis-4-Hydroxy-D-proline Fmoc-OSu Fmoc-L-glutamic acid

  • RARECHEM EM WB 0137
  • N-FMOC-TRANS-4-HYDROXY-L-PROLINE
  • N-FMOC-L-TRANS-4-HYDROXYPROLINE
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-TRANS-L-HYDROXYPROLINE
  • N-ALPHA-FMOC-L-TRANS-4-HYDROXYPROLINE
  • trans-N-Fmoc-L-4-hydroxyproline
  • trans-1-(((9H-Fluoren-9-yl)Methoxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
  • FMoc-Hyp
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Hyp-OH (Hyp of animal origin)
  • (9H-Fluoren-9-yl)MethOxy]Carbonyl Hyp-OH (Hyp of Non-animal origin)
  • Fmoc-Hyp-OH >=98.0% (sum of enantiomers, HPLC)
  • Fmoc-L-trans-4-hydroxyproline≥ 99% (HPLC)
  • 1,2-Pyrrolidinedicarboxylicacid, 4-hydroxy-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4R)-
  • N-Fmoc-trans-4-hydroxy-L-proline 98%
  • FMOC-(2S,4R)-(-)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
  • FMOC-L-4-HYDROXYPROLINE
  • FMOC-HYP-OH
  • FMOC-HYP-OH (TRANS)
  • FMOC-HYDROXYPROLINE
  • FMOC-L-T-4-HYDROXYPROLINE
  • FMOC-L-TRANS-4-HYDROXYPROLINE
  • FMOC-L-HYDROXYPROLINE
  • FMOC-L-HYP-OH
  • FMOC-TRANS-4-HYDROXY-L-PROLINE
  • FMOC-TRANS-4-HYP-OH
  • (2S,4R)-N-ALPHA-(Y-FLUORENYLMETHOXYCARBONYL)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
  • (2S,4R)-N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
  • N-Fmoc-cis-4-hydroxy-D-proline
  • FMOC-HYP-OH 99%MIN
  • (2R,4R)-N-FMOC-4-HYDROXY-D-PROLINE
  • NALPHA-9-Fluorenylmethoxycarbonyl-4-hydroxy-L-proline
  • (2S,4R)-1-(9H-Fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
  • trans-N-FMoc-4-hydroxy-L-proline, 97%
  • Fmoc-L-4-hydroxyproline ,98%
  • (2S,4R)-N-Fmoc-trans-4-hydroxy-L-proline
  • Fmoc-tarans-4-hydroxy-L-Proline
  • (2S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-3-hydroxypyrrolidine-2-carboxylic acid
  • Fmoc-L-hydroxyproline USP/EP/BP
  • (4R)-1-Fmoc-4-hydroxy-L-proline
  • -(2S,4R)-(-)-4-hydroxypyrrolidine-2-carboxylic acid,
  • TIANFU-CHEM_-Fmoc-L-hydroxyproline
  • G1-15
  • trans-N-Fmoc-4-hydroxy-L-proline
  • Icatibant Impurity 12
  • 88050-17-3
  • 8850-17-3
  • C20HNO5
  • Proline Derivatives
  • Peptide Synthesis
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Hydroxyproline [Hyp]
  • Unusual Amino Acids
  • Fmoc-Amino acid series
  • Heterocyclic Compounds
  • Amino Acids