ChemicalBook > CAS DataBase List > Cinchonidine

Cinchonidine

Product Name
Cinchonidine
CAS No.
485-71-2
Chemical Name
Cinchonidine
Synonyms
(-)-CINCHONIDINE;(-)-Cinchonidine;Cinchondine;(8s,9r)-cinchonidine;(8a,9R)-Cinchonan-9-ol;L-Cin;A-QUINIDINE;Cinchovatine;CINCHONIDINE;2'-Hydroxy-4'
CBNumber
CB5246395
Molecular Formula
C19H22N2O
Formula Weight
294.39
MOL File
485-71-2.mol
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Cinchonidine Property

Melting point:
204-206 °C(lit.)
alpha 
-115 º (c=1, EtOH)
Boiling point:
436.16°C (rough estimate)
Density 
1.0863 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
-107.5 ° (C=1, EtOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
0.25g/l
form 
Crystalline Powder
pka
5.80, 10.03(at 25℃)
color 
White to cream
PH
9 (0.2g/l, H2O, 20℃)
optical activity
[α]23/D 109.2°, c = 1.5 in ethanol
Water Solubility 
Insoluble
Sensitive 
Light Sensitive
Merck 
14,2286
BRN 
89690
Stability:
Stable, but light-sensitive. Incompatible with strong oxidizing agents.
InChIKey
KMPWYEUPVWOPIM-NAHPKXJFSA-N
LogP
2.68 at 25℃
CAS DataBase Reference
485-71-2(CAS DataBase Reference)
NIST Chemistry Reference
Cinchonidine(485-71-2)
EPA Substance Registry System
Cinchonan-9-ol, (8.alpha.,9R)- (485-71-2)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-42/43-36/37/38-20/22-48/22-43-22-63
Safety Statements 
22-24/25-36/37-36-26
RIDADR 
1544
WGK Germany 
3
RTECS 
GD2975000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29392900
Toxicity
LD50 i.p. in rats: 206 mg/kg (Johnson, Poe); LD50 orally in quail: >316 mg/kg (Schafer)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C80407
Product name
Cinchonidine
Purity
96%
Packaging
10g
Price
$38.4
Updated
2024/03/01
Sigma-Aldrich
Product number
PHL80961
Product name
(-)-Cinchonidine
Purity
phyproof? Reference Substance
Packaging
100mg
Price
$262
Updated
2024/03/01
Sigma-Aldrich
Product number
C80407
Product name
Cinchonidine
Purity
96%
Packaging
100g
Price
$138
Updated
2024/03/01
Sigma-Aldrich
Product number
44703
Product name
(−)-Cinchonidine
Purity
analyticalstandard
Packaging
100mg
Price
$45.9
Updated
2021/12/16
TCI Chemical
Product number
C0347
Product name
Cinchonidine
Purity
>98.0%(T)
Packaging
25g
Price
$73
Updated
2024/03/01
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Cinchonidine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

antiamebic, antiprotozoal

Uses

Cinchonidine occurs in most varieties of Cinchona bark and is stereoisomeric with Cinchonine. Cinchonidine exhibits Antimalarial properties.

Definition

ChEBI: 8-epi-Cinchonan in which a hydrogen at position 9 is substituted by hydroxy (R configuration). A diasteroisomer of cinchonine, it occurs in the bark of most varieties of Cinchona shrubs, and is frequently used for directing chirality in asymmetric synthesis.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise cinchonidine from aqueous EtOH. For the N-benzylcinchonidinium chloride see above entry in this section. [Beilstein 23 III/IV 2824.]

Cinchonidine Preparation Products And Raw materials

Raw materials

Preparation Products

Esfenvalerate 1,1'-Bis (di-t-butylphosphino)ferrocene palladium dichloride, (S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE Fosinopril 1,1'-SPIROBIINDANE-7,7'-DIOL 1,1'-Bis(di-tert-butylphosphino)ferrocene N-Benzylcinchonidinium chloride (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE Benazepril (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-PHENOXY QUININE SULFATE 2-(Dicyclohexylphosphino)biphenyl (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-DIMETHYLAMINE (R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE (S)-1,1'-SPIROBIINDANE-7,7'-DIOL
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Cinchonidine Suppliers

Americas 1 Belgium 4 Canada 2 China 276 Europe 2 France 2 Germany 8 India 17 Japan 7 Poland 1 Slovakia 1 Switzerland 2 The Netherlands 1 United Kingdom 21 United States 52 Global 397
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View Lastest Price from Cinchonidine manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Cinchonidine 485-71-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-30
Baoji Guokang Bio-Technology Co., Ltd.
Product
Cinchonidine 485-71-2
Price
US $371.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2021-06-04
Hebei Guanlang Biotechnology Co., Ltd.
Product
Cinchonidine 485-71-2
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-05-24

485-71-2, CinchonidineRelated Search:

4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Anisole 4-Methoxyphenylacetone Diethylstilbestrol Clothianidin 3-Methoxybenzaldehyde p-Anisidine Quinidine VINYL PROPIONATE 4-Methoxybenzylchloride Cinchonine Triethoxyvinylsilane Methanol DL-CARNITINE N-Vinyl-2-pyrrolidone Vinylmagnesium bromide p-Anisaldehyde (Trifluoromethoxy)benzene

  • (8-alpha,9r)-cinchonan-9-o
  • (8alpha,9theta)-cinchonan-9-o
  • (8s,9r)-cinchonidine
  • 2-Quinuclidinemethanol, alpha-4-quinolyl-5-vinyl-
  • Cinchonan-9-ol
  • Cinchonan-9-ol, (8alpha,9R)-
  • Cinchovatine
  • Cinchonidinederivedcatalyst
  • {5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl}(quinolin-4-yl)Methanol
  • Cinchonidine, 98.5-101% 100GR
  • Cinchonidine, 98.5-101% 25GR
  • Cinchondine
  • (-)-CINCHONIDINE
  • CINCHONIDINE
  • 1-Cinchonidine
  • (-)-Cinchonidine (total base), may cont. up to 5% quinine
  • cinchonidine .base
  • Cinchonidine ,98.5%
  • Cinchonidine,()-Cinchonidine
  • (-)-CINCHONIDINE FOR RESOLUTION OF RACEM
  • (-)-Cinchonidine, 99%, may contain up to 5% quinine
  • (-)-Cinchonidine for resolution of racemates for synthesis
  • (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](quinolin-4-yl)methanol
  • (3alpha,4beta,8alpha,9S)-cinchonan-9-ol
  • (3alpha,9R)-9-hydroxycinchonan-1-ium
  • (4beta,8alpha,9R)-cinchonan-1-ium-9-ol
  • (8alpha,9R)-9-hydroxycinchonan-1-ium
  • (9R)-cinchonan-1-ium-9-ol
  • (9R)-cinchonan-9-ol
  • Quinine Sulphate EP Impurity B
  • L-Cin
  • CINCHONAN-9-OL,(8,9R)-
  • A-QUINIDINE
  • ALPHA-QUINIDINE
  • (8alpha,9r)-cinchonan-9-ol
  • CINCHONIDINE: CINCHONAN-9-OL,(8,9R)-,
  • Cinchonidine,99%
  • [8α,9R]-Cinchonan-9-ol
  • Cinchonidine, 98.5-101%
  • CINCHONIDINE(RG)
  • L-CINCHONIDINE
  • Cinchonidine (base and/or unspecified salts)
  • 4-Quinolyl-(5-vinyl-1-azabicyclo[2.2.2]oct-2-yl)methanol
  • (R)-Quinolin-4-yl[(2S,4S,5R)-5-vinyl-1-azabicyclo[2.2.2]oct-2-yl]methanol
  • (8S,9R)-Cinchonan-9-ol
  • (-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine
  • (8a,9R)-Cinchonan-9-ol
  • (R)-[(4S,5R,7S)-5-Ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-quinolin-4-ylmethanol
  • Cinchonidine, 98%, for synthesis
  • Cinchonidine &gt
  • Quinine EP Impurity B
  • (R)-Quinolin-4-yl((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methanol
  • Cinchonidine USP/EP/BP
  • (-)-Cinchonidine
  • [(2R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-quinolin-4-ylmethanol
  • 2'-Hydroxy-4'
  • Cinchonidine (8CI)
  • (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](quinolin-4-yl)methanol (cinchonidine)