NW-09-15-1

Product Name: NW-09-15-1
CAS No.: 81323-58-2
Chemical Name: NW-09-15-1
Synonyms: tert-butyl (tert-butoxycarbonyl)-L-homoserinate;N-Boc-L-homoserine tert-butyl ester;-(s);NW-09-15-1;BOC-HSE-OTBU;BOC-Hser-OtBU;Boc-L-Homo-Serine Butyl Ester;N-Boc-L-hoMoserine Butyl Ester;-tert-Butyl 2-((tert-butoxycarbonyl);tert-Butyl (S)-2-(Boc-amino)-4-hydroxybutyrate
CBNumber: CB52487594
Molecular Formula: C13H25NO5
Formula Weight: 275.34
MOL File: 81323-58-2.mol

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NW-09-15-1 Property

Boiling point:: 393.4±37.0 °C(Predicted)
Density: 1.071±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.91±0.46(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C13H25NO5/c1-12(2,3)18-10(16)9(7-8-15)14-11(17)19-13(4,5)6/h9,15H,7-8H2,1-6H3,(H,14,17)/t9-/m0/s1
InChIKey: WFSWHDJTFHDJFE-VIFPVBQESA-N
SMILES: C(OC(C)(C)C)(=O)[C@H](CCO)NC(OC(C)(C)C)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B692910
Product name: N-(tert-Butoxycarbonyl)-(S)-homoserinetert-ButylEster
Packaging: 100mg
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142033
Product name: (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate
Packaging: 50mg
Price: $160
Updated: 2021/12/16

Activate Scientific

Product number: AS87383
Product name: N-Boc-L-homoserine tert-butyl ester
Purity: 95+% ee
Packaging: 250mg
Price: $244
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0017709
Product name: (S)-TERT-BUTYL-2-(TERT-BUTOXYCARBONYLAMINO)-4-HYDROXYBUTANOATE
Purity: 95.00%
Packaging: 0.25G
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142033
Product name: (S)-tert-Butyl 2-((tert-butoxycarbonyl)amino)-4-hydroxybutanoate
Packaging: 100mg
Price: $250
Updated: 2021/12/16

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NW-09-15-1 Chemical Properties,Usage,Production

Uses

N-(tert-Butoxycarbonyl)-(S)-homoserine tert-Butyl Ester is used as a reactant in the synthesis of N-substituted sultam carboxylic acids as novel glycogen synthase activators.

Synthesis

34582-32-6

81323-58-2

General procedure for the synthesis of N-(tert-butoxycarbonyl)-(S)-homoserine tert-butyl ester from N-Boc-L-aspartic acid 1-tert-butyl ester: 1b) Boc-L-Asp-OtBu (3.00 g, 10.4 mmol) was dissolved in 1,2-dimethoxyethane (10 mL) at -15°C and 4-methylmorpholine (1.14 mL, 10.4 mmol) and isobutyl chloroformate (1.35 mL, 10.4 mmol) were added sequentially. The reaction mixture was stirred at -15°C for 10 min before the precipitate was removed by filtration and the precipitate was washed with cold 1,2-dimethoxyethane (20 mL). A solution of sodium borohydride (0.59 g, 15.6 mmol) in water (5 mL) was slowly added to the filtrate at -15°C. After 5 min, the reaction was terminated by adding water (250 mL). The reaction mixture was extracted with ethyl acetate, the organic layers were combined and dried over anhydrous sodium sulfate. The organic layer was concentrated under reduced pressure to give tert-butyl N-(tert-butoxycarbonyl)-(S)-homoserine. Yield: 2.70 g, 9.81 mmol, 95% yield. MS (ESIpos): m/z = 276 [M+H]+. 1H-NMR (400 MHz, chloroform-d): δ[ppm] = 1.46 (s, 9H), 1.48 (s, 9H), 1.51-1.58 (m, 1H), 2.09-2.20 (m, 1H), 3.45 (br.s., 1H), 3.55-3.76 (m, 2H), 4.31-4.40 (m, 1H). 5.35 (d, 1H).

References

[1] Patent: EP2322500, 2011, A1. Location in patent: Page/Page column 26-27
[2] Patent: WO2011/57986, 2011, A1. Location in patent: Page/Page column 53
[3] Organic and Biomolecular Chemistry, 2017, vol. 15, # 31, p. 6656 - 6667
[4] Organic Letters, 2001, vol. 3, # 20, p. 3153 - 3155
[5] Tetrahedron, 2017, vol. 73, # 9, p. 1265 - 1274

NW-09-15-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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NW-09-15-1 Suppliers

China 48 India 1 United Kingdom 1 United States 3 Global 53

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81323-58-2, NW-09-15-1Related Search:

BOC-L-3-FLUOROPHENYLALANINE N-Boc-L-valine (S)-N-Boc-allylglycine (S)-N-Boc-3-aminobutyric acid N-Boc-L-tert-Leucine (S)-N-Boc-3-Bromophenylalanine BOC-GLU(OME)-OH Boc-Hyp-OH Boc-L-glutamic acid 1-tert-butyl ester (S)-N-BOC-4-Bromophenylalanine BOC-7-HYDROXY-TIC-OH N-(tert-Butoxycarbonyl)-L-glutamine Boc-L-aspartic acid 4-benzyl ester BOC-L-ASPARTIMOL T-BUTYL ESTER

NW-09-15-1

(S)-tert-butyl 2-(tert-butoxycarbonylamino)-4-hydroxybutanoate

N-Boc-L-hoMoserine Butyl Ester

N-t-Butyloxycarbonyl-L-hoMoserine-t-butyl ester

N-Boc-L-homoserine tert-butyl ester

-tert-Butyl 2-((tert-butoxycarbonyl)

N-(tert-butyloxycarbonyl)-(S)-homoserine tert-butyl ester

tert-butyl (tert-butoxycarbonyl)-L-homoserinate

BOC-Hser-OtBU

2(S)-2-tert-butoxycarbonylamino-4-hydroxybutyric acid tert-butyl ester

2-Methyl-2-propanyl N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-hoMoserinate

BOC-HSE-OTBU

L-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester

-(s)

(2S)-tert-butyl 2-[N-Boc-amino]-4-hydroxybutanoate

Boc-L-Homo-Serine Butyl Ester

tert-Butyl (S)-2-(Boc-amino)-4-hydroxybutyrate

N-Boc-[(1,1-Dimethylethoxy)carbonyl]-L-homoserine

81323-58-2