ChemicalBook > CAS DataBase List > methyl 5-bromo-1H-pyrrole-2-carboxylate

methyl 5-bromo-1H-pyrrole-2-carboxylate

Product Name
methyl 5-bromo-1H-pyrrole-2-carboxylate
CAS No.
934-07-6
Chemical Name
methyl 5-bromo-1H-pyrrole-2-carboxylate
Synonyms
5-bromo-1H-Pyrrole-2-carboxylic acid methyl ester;1H-Pyrrole-2-carboxylic acid, 5-bromo-, methyl ester;methyl 5-bromo-1H-pyrrole-2-carboxylate, 10 mM in DMSO
CBNumber
CB52500363
Molecular Formula
C6H6BrNO2
Formula Weight
204.02
MOL File
934-07-6.mol
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methyl 5-bromo-1H-pyrrole-2-carboxylate Property

Melting point:
101-103 °C
Boiling point:
290.5±20.0 °C(Predicted)
Density 
1.674±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Solid
pka
14.18±0.50(Predicted)
color 
White to off-white
InChI
InChI=1S/C6H6BrNO2/c1-10-6(9)4-2-3-5(7)8-4/h2-3,8H,1H3
InChIKey
ZYBOXSDTMZRWBC-UHFFFAOYSA-N
SMILES
N1C(Br)=CC=C1C(OC)=O
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M292715
Product name
Methyl5-Bromo-1H-pyrrole-2-carboxylate
Packaging
10g
Price
$2625
Updated
2021/12/16
TRC
Product number
M292715
Product name
Methyl5-Bromo-1H-pyrrole-2-carboxylate
Packaging
25g
Price
$4725
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-9-2W
Product name
Methyl 5-bromo-1H-pyrrole-2-carboxylate
Packaging
250mg
Price
$176
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-9-2W
Product name
Methyl 5-bromo-1H-pyrrole-2-carboxylate
Packaging
1g
Price
$392
Updated
2021/12/16
Matrix Scientific
Product number
119330
Product name
Methyl 5-bromo-1H-pyrrole-2-carboxylate
Purity
95+%
Packaging
1g
Price
$485
Updated
2021/12/16
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methyl 5-bromo-1H-pyrrole-2-carboxylate Chemical Properties,Usage,Production

Uses

Methyl 5-Bromo-1H-pyrrole-2-carboxylate is a chemical reagent used in pharmaceutical synthesis.

Synthesis

1193-62-0

934-07-6

Synthesis of 5-bromo-1H-pyrrole-2-carboxylic acid methyl ester (53): 1H-pyrrole-2-carboxylic acid methyl ester (52; 10 g, 80 mmol) was dissolved in a solvent mixture of 800 mL tetrahydrofuran (THF) and 400 mL methanol (MeOH). The reaction mixture was cooled to 0 °C. N-bromosuccinimide (NBS; 15 g, 8.4 mmol) was added in 5 additions in batches over 1.5 hours. After addition, the reaction mixture was continued to be stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated and purified by silica gel column chromatography (eluent: 2% ethyl acetate/petroleum ether) to afford 4.3 g of 5-bromo-1H-pyrrole-2-carboxylic acid methyl ester 53 as a white solid in 26% yield.The LCMS analysis resulted in: m/z 206.0 [M + H] and a retention time t R = 1.50 min.

References

[1] Journal of the American Chemical Society, 2006, vol. 128, # 18, p. 6054 - 6055
[2] Chemistry - A European Journal, 2009, vol. 15, # 28, p. 6910 - 6919
[3] Organic and Biomolecular Chemistry, 2013, vol. 11, # 16, p. 2574 - 2577
[4] Patent: WO2017/31213, 2017, A1. Location in patent: Paragraph 00361
[5] Patent: US2002/6943, 2002, A1

methyl 5-bromo-1H-pyrrole-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from methyl 5-bromo-1H-pyrrole-2-carboxylate manufacturers

Career Henan Chemical Co
Product
methyl 5-bromo-1H-pyrrole-2-carboxylate 934-07-6
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-09

934-07-6, methyl 5-bromo-1H-pyrrole-2-carboxylateRelated Search:

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  • 5-bromo-1H-Pyrrole-2-carboxylic acid methyl ester
  • 1H-Pyrrole-2-carboxylic acid, 5-bromo-, methyl ester
  • methyl 5-bromo-1H-pyrrole-2-carboxylate, 10 mM in DMSO
  • 934-07-6