ChemicalBook > CAS DataBase List > LY 2784544

LY 2784544

Product Name
LY 2784544
CAS No.
1229236-86-5
Chemical Name
LY 2784544
Synonyms
Gandotinib (LY2784544);3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine LY 2784544;CS-13;LY2874544;LY 2784544;LY2784544/LY-2784544;LY2784544(gandotinib);Gandotinib, 10 mM in DMSO;Gandotinib (LY2784544) ，S2179;Gandotinib LY2784544 LY-2784544
CBNumber
CB52514748
Molecular Formula
C23H25ClFN7O
Formula Weight
469.94
MOL File
1229236-86-5.mol
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LY 2784544 Property

Density 
1.45
storage temp. 
Store at -20°C
solubility 
≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
pka
14.12±0.10(Predicted)
color 
Light yellow to yellow
InChIKey
SQSZANZGUXWJEA-UHFFFAOYSA-N
SMILES
C12=NC(C)=C(CC3=CC=C(Cl)C=C3F)N1N=C(NC1C=C(C)NN=1)C=C2CN1CCOCC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2567
Product name
LY2784544
Purity
≥98% (HPLC)
Packaging
5MG
Price
$122.29
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2567
Product name
LY2784544
Purity
≥98% (HPLC)
Packaging
25MG
Price
$291.9
Updated
2025/07/31
Cayman Chemical
Product number
16705
Product name
LY2784544
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
16705
Product name
LY2784544
Purity
≥98%
Packaging
5mg
Price
$135
Updated
2024/03/01
Cayman Chemical
Product number
16705
Product name
LY2784544
Purity
≥98%
Packaging
10mg
Price
$239
Updated
2024/03/01
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LY 2784544 Chemical Properties,Usage,Production

Uses

LY2784544 is a JAK2 inhibitor. LY2784544 may be used as a potential treatment for patients with myeloproliferative neoplasm.

Definition

ChEBI: Gandotinib is a member of pyridazines.

Biological Activity

LY2784544 is an orally active, ATP-competitive, potent and JAK2-selective janus tyrosine kinase inhibitor (IC50/[ATP] = 2.52 nM/5 μM/JAK2, 19.8 nM/20 μM/JAK1, 48.0 nM/2 μM/JAK3) with little activity toward 79 other kinases. LY2784544 selectively inhibits signaling/proliferation driven by oncogenic JAK2V617F (IC50 = 20/55 nM) over those mediated by wt JAK2 upon IL-3 induction (IC50 = 1183/1309 nM) in Ba/F3 cultures and displays in vivo efficacious in a JAK2V617F-induced murine MPN model (10-80 mg/kg bid po.). LY2784544 is also reported to display Zn-dependent (optimal [Zn+2] = 100 μM) GPR39 agonist activity, but not 11 other GPRs.

in vivo

Gandotinib (LY2784544) effectively inhibits STAT5 phosphorylation in Ba/F3-JAK2V617F-GFP (green fluorescent protein) ascitic tumor cells (TED50=12.7 mg/kg) and significantly reduces (P<0.05) Ba/F3-JAK2V617F-GFP tumor burden in the JAK2V617F-induced MPN model (TED50=13.7 mg/kg, twice daily)[1].

target

wild-type JAK2

IC 50

JAK2: 3 nM (IC50); Tyk2: 44 nM (IC50); JAK3: 48 nM (IC50); FGFR2: 32 nM (IC50); FGFR3: 106 nM (IC50); Flt-4: 25 nM (IC50); KDR: 109 nM (IC50); FLT3: 4 nM (IC50); TRKB: 95 nM (IC50); ALK: 138 nM (IC50); MUSK: 147 nM (IC50); AURKA: 168 nM (IC50); MAP3K9: 299 nM (IC50)

LY 2784544 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 2784544 Suppliers

China 159 India 2 United Kingdom 1 United States 21 Global 183
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
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View Lastest Price from LY 2784544 manufacturers

Apeloa production Co.,Limited
Product
LY2784544 1229236-86-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000
Release date
2024-06-17
Dingwang Technology (Wuhan) Co., Ltd.
Product
Tucatinib；LY 2784544 1229236-86-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-07
Career Henan Chemical Co
Product
LY 2784544 1229236-86-5
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

1229236-86-5, LY 2784544Related Search:

LY 2606368 LY-2562175 LY2228820 Etalocib 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol LY3214996 LY2584702 LY2409881 trihydrochloride LY-364947 LY 88074 (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 Tozasertib PD 0325901 Momelotinib (+)-JQ-1 Fedratinib PACRITINIB |CAS 937272-79-2

  • LY 2784544
  • 3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine
  • 3-(4-chloro-2-fluorobenzyl)-2-Methyl-N-(3-Methyl-1H-pyrazol-5-yl)-8-(MorpholinoMethyl)iMidazo[1,2-b]pyridazin-6-aMine
  • LY2784544/LY-2784544
  • IMidazo[1,2-b]pyridazin-6-aMine, 3-[(4-chloro-2-fluorophenyl)Methyl]-2-Methyl-N-(5-Methyl-1H-pyrazol-3-yl)-8-(4-MorpholinylMethyl)-
  • LY2874544
  • CS-13
  • Gandotinib (LY2784544)
  • 3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine LY 2784544
  • LY2784544(gandotinib)
  • 3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[
  • 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine
  • Gandotinib LY2784544 LY-2784544
  • VEGFR,inhibit,FGFR,LY-2784544,Janus kinase,CD135,FLT3,Cluster of differentiation antigen 135,LY 2784544,Inhibitor,Gandotinib,Fms like tyrosine kinase 3,Vascular endothelial growth factor receptor,JAK,Fibroblast growth factor receptor
  • Gandotinib, 10 mM in DMSO
  • Gandotinib (LY2784544) ，S2179
  • 1229236-86-5
  • C23H25ClFN7O
  • Inhibitors
  • JAK
  • STAT
  • Inhibitor
  • JAK/STAT