ChemicalBook > CAS DataBase List > MK-3903

MK-3903

Product Name
MK-3903
CAS No.
1219737-12-8
Chemical Name
MK-3903
Synonyms
MK-3903;MK-3903 ，S8803;MK-3903, 10 mM in DMSO;MK-3903; MK 3903; MK3903;1219737-12-8;AMPK,MK3903,AMP-activated protein kinase,inhibit,Inhibitor,MK-3903;Benzoic acid, 5-[(5-[1,1'-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-;5-((6-([1,1'-Biphenyl]-4-yl)-5-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid
CBNumber
CB52516050
Molecular Formula
C27H19ClN2O3
Formula Weight
454.9
MOL File
1219737-12-8.mol
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MK-3903 Property

Boiling point:
712.6±70.0 °C(Predicted)
Density 
1.349±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);219.83(Max Conc. mM)
form 
A solid
pka
3.40±0.25(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29661
Product name
MK-3903
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
29661
Product name
MK-3903
Packaging
25mg
Price
$534
Updated
2024/03/01
Cayman Chemical
Product number
29661
Product name
MK-3903
Packaging
5mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
29661
Product name
MK-3903
Packaging
10mg
Price
$310
Updated
2024/03/01
TRC
Product number
M424850
Product name
MK-3903
Packaging
1mg
Price
$85
Updated
2021/12/16
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MK-3903 Chemical Properties,Usage,Production

Uses

MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.

in vivo

The pharmacokinetics of MK-3903 (compound 42) in C57BL/6 mice, Sprague to Dawley rats, and beagle dogs are characterized by moderate systemic plasma clearance (5.0 to13 mL/min/kg), a volume of distribution at steady state of 0.6 to 1.1 L/kg, and a terminal halflife of ~2h. Acute oral administration of MK-3903 (3, 10, and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses[1].

IC 50

AMPK: 8 nM (EC50)

MK-3903 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-3903 Suppliers

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1219737-12-8, MK-3903Related Search:

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK-1775 MK-0941 MK-2206 2HCl MK-8353 MK-8998 MK-4101 MK8745 mk-1064 MK 0557 MK-0812 (Succinate) MKC9989 MKC3946

  • MK-3903
  • MK-3903; MK 3903; MK3903;1219737-12-8
  • Benzoic acid, 5-[(5-[1,1'-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-
  • AMPK,MK3903,AMP-activated protein kinase,inhibit,Inhibitor,MK-3903
  • 5-((6-([1,1'-Biphenyl]-4-yl)-5-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid
  • MK-3903, 10 mM in DMSO
  • MK-3903 ，S8803
  • 1219737-12-8
  • API