ChemicalBook > CAS DataBase List > N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

Product Name
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
CAS No.
312917-14-9
Chemical Name
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
Synonyms
CS-320;JNK-5A;SC-20267;SC-202671;TCS JNK 5a;F0016-0404;SC-202671, >98%;TCS JNK 5a, >98%;JNK Inhibitor IX;SC-202671 TCSJNK5a
CBNumber
CB52518872
Molecular Formula
C20H16N2OS
Formula Weight
332.42
MOL File
312917-14-9.mol
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N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide Property

Melting point:
88-90oC
Boiling point:
486.8±45.0 °C(Predicted)
Density 
1.32±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 13 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming)
form 
Tan solid
pka
11.95±0.20(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420136
Product name
JNK Inhibitor IX - CAS 312917-14-9 - Calbiochem
Packaging
5mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
15624
Product name
JNK Inhibitor IX
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
15624
Product name
JNK Inhibitor IX
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
15624
Product name
JNK Inhibitor IX
Purity
≥98%
Packaging
25mg
Price
$225
Updated
2024/03/01
Cayman Chemical
Product number
15624
Product name
JNK Inhibitor IX
Purity
≥98%
Packaging
50mg
Price
$419
Updated
2024/03/01
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N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide Chemical Properties,Usage,Production

Description

JNK inhibitor IX (312917-14-9) inhibits JNK2 and JNK3 via binding to the ATP binding domain. Displays little or no activity against JNK1, p38α and a panel of 30 other kinases.1?Induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells.2

Uses

JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product.

Definition

ChEBI: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthalenecarboxamide is a naphthalenecarboxamide.

storage

Store at RT

References

1) Angell?et al. (2007),?N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3; Med. Chem. Lett.,?17?1296 2) Jang?et al.?(2014),?Inhibition of JNK2 and JNK3 by JNK inhibitor IX induces prometaphase arrest-dependent apoptotic cell death in human Jurkat T cells?; Biochem. Biophys. Res. Commun.,?452?845

N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide Suppliers

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View Lastest Price from N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide manufacturers

Career Henan Chemical Co
Product
N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide 312917-14-9
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week 100kg
Release date
2019-09-05

312917-14-9, N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamideRelated Search:

ZM 447439 ZM 306416 hydrochloride SU 4312 JX401 AS601245 JNK-IN-8 U0126-EtOH 1,9-Pyrazoloanthrone ABT-199 ABT 737 SCH772984

  • JNK Inhibitor IX
  • N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide
  • TCS JNK 5a
  • 1-NaphthalenecarboxaMide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-
  • SC-202671
  • N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide
  • N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)-1-naphthalenecarboxamide JNK Inhibitor IX
  • N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide
  • F0016-0404
  • SC-202671, >98%
  • TCS JNK 5a, >98%
  • JNK INHIBITOR IX;TCSJNK-5A)
  • CS-320
  • N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
  • JNK Inhibitor IX, >=98%
  • TCS JNK 5a(JNK Inhibitor IX)
  • SC-20267
  • JNK-5A
  • N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide USP/EP/BP
  • SC202671|||SC 202671|||N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide|||JNK Inhibitor IX|||SC-202671
  • SC-202671 TCSJNK5a
  • 312917-14-9
  • Inhibitors