Torin 1

ChemicalBook > CAS DataBase List > Torin 1

Product Name: Torin 1
CAS No.: 1222998-36-8
Chemical Name: Torin 1
Synonyms: Torin 1;CS-1958;Torin 1, >=98%;TORIN-1;TORIN 1;Torin 1 USP/EP/BP;Torin 1, mTOR inhibitor;mTOR Inhibitor XI, Torin1 - Calbiochem;Torin 1 - MTOR inhibitor,potent and selective;1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naph;1-[4-(4-PROPANOYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL]-9-QUINOLIN-3-YLBENZO[H][1,6]NAPHTHYRIDIN-2-ONE
CBNumber: CB52534704
Molecular Formula: C35H28F3N5O2
Formula Weight: 607.62
MOL File: 1222998-36-8.mol

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Torin 1 Property

Melting point:: >223°C (dec.)
Boiling point:: 817.2±65.0 °C(Predicted)
Density: 1.362
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 8 mg/ml).
form: Yellowish-white powder
pka: 4.19±0.20(Predicted)
color: White or off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Safety

Safety Statements: 24/25
HS Code: 29334900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 475991
Product name: mTOR Inhibitor XI, Torin1 - Calbiochem<br />mTOR Inhibitor XI, Torin1, CAS 1222998-36-8, is a cell-permeable, highly potent, ATP-competitive inhibitor of mTOR and DNA-PK (IC50 = 4.32 and 6.34 nM, respectively).
Packaging: 10mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 10997
Product name: Torin 1
Purity: ≥95%
Packaging: 10mg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 10997
Product name: Torin 1
Purity: ≥95%
Packaging: 25mg
Price: $330
Updated: 2024/03/01

Cayman Chemical

Product number: 10997
Product name: Torin 1
Purity: ≥95%
Packaging: 50mg
Price: $537
Updated: 2024/03/01

Tocris

Product number: 4247
Product name: Torin1
Purity: ≥98%(HPLC)
Packaging: 10
Price: $278
Updated: 2021/12/16

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Torin 1 Chemical Properties,Usage,Production

Description

Torin1 (1222998-36-8) is a potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively.1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).2 Induces autophagy.3 Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.4 Downregulates NGF expression in RSC96 cells.5

Chemical Properties

White Solid

Uses

Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.

Definition

ChEBI: Torin 1 is a member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1. It is a potent inhibitor of mTOR and exhibits anti-cancer properties. It has a role as a mTOR inhibitor and an antineoplastic agent. It is a N-acylpiperazine, a N-arylpiperazine, an organofluorine compound, a pyridoquinoline and a member of quinolines.

General Description

A cell-permeable pyridinonequinoline derivative that acts as a highly potent, ATP-competitive inhibibitor against mTOR and DNA-PK (IC₅₀ = 4.32 and 6.34 nM, respectively, in cell-free kinase assays), inhibiting class I (IC₅₀ =171, 250, and 564 nM, respectively, against P110γ, P110α/P85α, and P110δ/P85α, respectively), class II (IC₅₀ =176 and 564 nM, respectively, against C2α, and C2β, respectively), and class III (IC₅₀ = 533 nM against hVPS34) PI 3-K only at much higher concentrations. Effectively inhibits mTORC1-mediated S6K1 Thr389 phosphorylation in MEF cultures (IC₅₀ = 2 nM) in vitro, as well as mTORC2-mediated Akt Ser473 and mTORC1-dependent S6 Ser235/236 phosphorylations in murine lung and liver in vivo (up to 6 h after single i.p. dose at 20 mg/kg). Despite its poor in vivo stability (T_1/2 = 4.52 h in mice; 10 mg/kg i.p.), Torin1 is reported to completely suppress U87MG-derived tumor expansion in mice when administered via daily i.p. at a high dosage of 200 mg/kg. Also reported to effectively inhibit cellular mTORC1 functionalities known to be rapamycin-resistant (Cat. Nos. 553210, 553211, and 553212).

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

References/Citations:

Torin 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Torin 1 manufacturers

Career Henan Chemical Co

Product: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one 1222998-36-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

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TORIN-1;TORIN 1

CS-1958

mTOR Inhibitor XI, Torin1 - Calbiochem

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one

1-[4-(4-PROPANOYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL]-9-QUINOLIN-3-YLBENZO[H][1,6]NAPHTHYRIDIN-2-ONE

Torin 1

Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-

1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one Torin 1

Torin 1 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one

1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one

Torin 1, >=98%

1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naph

Torin 1 USP/EP/BP

Torin 1 - MTOR inhibitor,potent and selective

Torin 1, mTOR inhibitor

1222998-36-8

C35H28F3N5O2

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pfizer Compounds

Pharmaceuticals

PI3K/Akt/mTOR

Inhibitors

Akt

mTOR

PI3K