WAY-600

ChemicalBook > CAS DataBase List > WAY-600

Product Name: WAY-600
CAS No.: 1062159-35-6
Chemical Name: WAY-600
Synonyms: WAY-600;WAY-600;WAY 600;WAY-600 USP/EP/BP;6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine;4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine;6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine;1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-
CBNumber: CB52561500
Molecular Formula: C28H30N8O
Formula Weight: 494.59
MOL File: 1062159-35-6.mol

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WAY-600 Property

Density: 1.43
storage temp.: Store at -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder
pka: 16.08±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29214
Product name: WAY-600
Packaging: 1mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 29214
Product name: WAY-600
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 29214
Product name: WAY-600
Packaging: 5mg
Price: $330
Updated: 2024/03/01

ApexBio Technology

Product number: B1641
Product name: WAY-600
Packaging: 1unit
Price: $28
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010224
Product name: WAY-600
Purity: 95.00%
Packaging: 5MG
Price: $459.8
Updated: 2021/12/16

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WAY-600 Chemical Properties,Usage,Production

Biological Activity

WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with IC50 of 9 nM for recombinant mTOR enzyme. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.

in vitro

WAY-600 decreased exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically . Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. It dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association ) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).

in vivo

Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, po daily).

target

mTOR

9 nM (IC ₅₀ )

mTORC1

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mTORC2

PI3K alpha

1.96 μM (IC ₅₀ )

PI3K gamma

8.45 μM (IC ₅₀ )

WAY-600 Preparation Products And Raw materials

Raw materials

Preparation Products

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WAY-600 Suppliers

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1062159-35-6, WAY-600Related Search:

SAM-315 N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) WAY 208466 dihydrochloride WAY-204688 MAY-262611 WAY-151932 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol WYE-354 TENOVIN-1 PELITINIB KU-0063794 Afatinib Canertinib

WAY-600

6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

WAY-600;WAY 600

4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine

1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-

WAY-600 USP/EP/BP

4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine

1062159-35-6

C28H30N8O

Inhibitors

Akt

mTOR

PI3K

PI3K/Akt/mTOR