WAY-600

ChemicalBook > CAS DataBase List > WAY-600

Product Name: WAY-600
CAS No.: 1062159-35-6
Chemical Name: WAY-600
Synonyms: WAY-600;WAY-600;WAY 600;WAY-600 USP/EP/BP;6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine;4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine;6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-
CBNumber: CB52561500
Molecular Formula: C28H30N8O
Formula Weight: 494.59
MOL File: 1062159-35-6.mol

Less

WAY-600 Property

Density: 1.43
storage temp.: Store at -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder
pka: 16.08±0.30(Predicted)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 29214
Product name: WAY-600
Packaging: 1mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 29214
Product name: WAY-600
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Cayman Chemical

Product number: 29214
Product name: WAY-600
Packaging: 5mg
Price: $330
Updated: 2024/03/01

ApexBio Technology

Product number: B1641
Product name: WAY-600
Packaging: 1unit
Price: $28
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0010224
Product name: WAY-600
Purity: 95.00%
Packaging: 5MG
Price: $459.8
Updated: 2021/12/16

Less

WAY-600 Chemical Properties,Usage,Production

Biological Activity

WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with IC50 of 9 nM for recombinant mTOR enzyme. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.

in vitro

WAY-600 decreased exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically . Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. It dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association ) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).

in vivo

Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, po daily).

target

mTOR

9 nM (IC ₅₀ )

mTORC1

< /span>

mTORC2

PI3K alpha

1.96 μM (IC ₅₀ )

PI3K gamma

8.45 μM (IC ₅₀ )

WAY-600 Preparation Products And Raw materials

Raw materials

Preparation Products

Less

WAY-600 Suppliers

China 66 France 1 India 1 United States 12 Global 80

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1494
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3423
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9972
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9254
Advantage: 55

Chengdu Dianchun Technology Co., Ltd

Tel: 400-1166-196 18502815961
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14623
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131981
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28821
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3244
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Fujian boshi pharmaceutical technology co. LTD

Tel: 18120708884
Email: 393612455@qq.com
Country: China
ProdList: 255
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10523
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 28404
Advantage: 58

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Tel: 86-571-88216897,88216896 13588875226
Fax: 86-571-88216895
Email: sales@hzclap.com
Country: CHINA
ProdList: 6313
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 15093356674;
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30255
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-61998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9763
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9215
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4576
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4495
Advantage: 58

Zhengzhou Akem Chemical Co., Ltd

Tel: 13303867194
Email: 3001317055@qq.com
Country: China
ProdList: 9627
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10624
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6712
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9892
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 2780
Advantage: 58

Shanghai Tachizaki Biomedical Research Center

Tel: 18014399201
Email: sales@chemlab-tachizaki.com
Country: China
ProdList: 2490
Advantage: 58

Wuhan Jingkangen Biomedical Technology Co., Ltd

Tel: 13720134139 13720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 5223
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4164
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 8740
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 32686
Advantage: 60

Wuhan Jingkang en Biomedical Technology Co., Ltd

Tel: +8613720134139
Email: orders@jknbiochem.com
Country: China
ProdList: 4604
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6652
Advantage: 58

Nanjing Sai Ruirui Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: sales@shrbio.com
Country: CHINA
ProdList: 6873
Advantage: 58

Shanghai yiji industries Co., Ltd.

Tel: --
Fax: --
Email: yiji01@foxmail.com
Country: China
ProdList: 6294
Advantage: 50

Shanghai Yijie Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: SHYIJIEBIO@126.COM
Country: CHINA
ProdList: 3510
Advantage: 58

Shanghai Caiyou Industrial Co., Ltd.

Tel: --
Fax: --
Email: 15821073967@163.com
Country: CHINA
ProdList: 6894
Advantage: 58

Shimadzu (Shanghai) Experimental Equipment Co., Ltd.

Tel: --
Fax: --
Email: marketing@shimadzu-gl.com.cn
Country: CHINA
ProdList: 117
Advantage: 58

1062159-35-6, WAY-600Related Search:

SAM-315 N-[4-(2-BROMO-4,5-DIFLUOROPHENOXY)PHENYL]-L-ASPARAGINE BenzenesulfonaMide, 5-(phenylsulfonyl)-N-4-piperidinyl-2-(trifluoroMethyl)- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) WAY 208466 dihydrochloride WAY-204688 MAY-262611 WAY-151932 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol WYE-354 TENOVIN-1 PELITINIB KU-0063794 Afatinib Canertinib

WAY-600

6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine

6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine

WAY-600;WAY 600

4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine

1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-

WAY-600 USP/EP/BP

1062159-35-6

C28H30N8O

Inhibitors

Akt

mTOR

PI3K

PI3K/Akt/mTOR