WAY-600
- Product Name
- WAY-600
- CAS No.
- 1062159-35-6
- Chemical Name
- WAY-600
- Synonyms
- WAY-600;WAY-600;WAY 600;WAY-600 USP/EP/BP;6-(1H-indol-5-yl)-4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine;4-[6-(1H-indol-5-yl)-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-4-yl]morpholine;6-(1H-Indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine;4-(6-(1H-Indol-5-yl)-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholine;1H-Pyrazolo[3,4-d]pyrimidine, 6-(1H-indol-5-yl)-4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-
- CBNumber
- CB52561500
- Molecular Formula
- C28H30N8O
- Formula Weight
- 494.59
- MOL File
- 1062159-35-6.mol
WAY-600 Property
- Density
- 1.43
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO > 10 mM
- form
- Powder
- pka
- 16.08±0.30(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29214
- Product name
- WAY-600
- Packaging
- 1mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 29214
- Product name
- WAY-600
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 29214
- Product name
- WAY-600
- Packaging
- 5mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- B1641
- Product name
- WAY-600
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
- Product number
- API0010224
- Product name
- WAY-600
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $459.8
- Updated
- 2021/12/16
WAY-600 Chemical Properties,Usage,Production
Biological Activity
WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with IC50 of 9 nM for recombinant mTOR enzyme. It blocks mTOR complex 1/2 (mTORC1/2) assembly and activation.
in vitro
WAY-600 decreased exhibits a concentration-dependent and time-dependent inhibition of f HepG2 and Huh-7 cells viability. Following WAY-600 (1-1000 nM) treatment, the number of HepG2 cell colonies is dramatically . Meanwhile, BrdU incorporation in HepG2 cells is also inhibited with WAY-600 treatment. It dose-dependently increases the activity of caspase-3 and caspase-9 in HepG2 cells. WAY-600 disrupts assemble of mTORC1 (mTOR-Raptor association ) and mTORC2 (mTOR-Rictor association). Activation of mTORC1 (indicated by p-S6K1 and p-4E-BP1) and mTORC2 is almost blocked by WAY-600 (100 nM).
in vivo
Administration of WAY-600 (10 mg/kg, daily) inhibits HepG2 tumor growth in nude mice. Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice. Importantly, the in vivo anti-cancer activity by WAY-600 is further potentiated with the co-administration of MEK-162 (2.5 mg/kg, po daily).
target
| mTOR 9 nM (IC 50 ) | mTORC1 < /span> | mTORC2
| PI3K alpha 1.96 μM (IC 50 ) | PI3K gamma 8.45 μM (IC 50 ) |