ZLJ-6

Product Name: ZLJ-6
CAS No.: 1051931-39-5
Chemical Name: ZLJ-6
Synonyms: ZLJ-6;ZLJ-6 Exclusive;QEJPXTVPNIOEHZ-VEZAGKLZSA-N
CBNumber: CB52592894
Molecular Formula: C13H17N3O6S2
Formula Weight: 375.421
MOL File: 1051931-39-5.mol

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ZLJ-6 Property

storage temp.: Store at -20°C
solubility: ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 10mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 25mg
Price: $660
Updated: 2024/03/01

ApexBio Technology

Product number: C4357
Product name: ZLJ-6
Packaging: 25mg
Price: $753
Updated: 2021/12/16

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ZLJ-6 Chemical Properties,Usage,Production

Description

ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC₅₀ = 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective COX inhibitors.

in vitro

zlj-6 was identified as a potent inhibitor of cyclooxygenase in human whole blood. it also inhibited the production of thromboxane b(2) and prostaglandin e(2) in calcium ionophore a23187-induced human and rat whole blood, and rat peritoneal leukocytes. zlj-6 suppressed the activity of 5-lipoxygenase in the rat basophilic leukemia (rbl-1) cell lysate and in intact cells and reduced the generation of leukotriene b(4) (ltb(4)) in a23187-stimulated human or rat whole blood, and rat peritoneal leukocytes [1].

in vivo

orally administered zlj-6 demonstrated potent anti-inflammatory activity in the carrageenin-induced paw oedema model in rats and showed analgesic activity in the acetic acid-induced abdominal construction model in mice. no gastrointestinal ulcers were found with the anti-inflammatory dose (30 mg/kg) in normal rats [1].

IC 50

0.73, 0.31, and 0.99 μm for cox-1, cox-2, and 5-lo, respectively

References

[1] li, l. ,ji, h.,sheng, l., et al. the anti-inflammatory effects of zlj-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. european journal of pharmacology 607 (1-3), 244-250 (2009).

ZLJ-6 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZLJ-6 Suppliers

China 22 United States 3 Global 25

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ZLJ-6

ZLJ-6 Exclusive

QEJPXTVPNIOEHZ-VEZAGKLZSA-N

1051931-39-5

C12H13N3O3SCH3SO3H