ZLJ-6

Product Name: ZLJ-6
CAS No.: 1051931-39-5
Chemical Name: ZLJ-6
Synonyms: ZLJ-6;ZLJ-6 Exclusive;QEJPXTVPNIOEHZ-VEZAGKLZSA-N
CBNumber: CB52592894
Molecular Formula: C13H17N3O6S2
Formula Weight: 375.421
MOL File: 1051931-39-5.mol

More

Less

ZLJ-6 Property

storage temp.: Store at -20°C
solubility: ≤10mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 10mg
Price: $302
Updated: 2024/03/01

Cayman Chemical

Product number: 13271
Product name: ZLJ-6
Purity: ≥98%
Packaging: 25mg
Price: $660
Updated: 2024/03/01

AK Scientific

Product number: 2105AH
Product name: 2-Amino-1,5-dihydro-1-methyl-5-[[(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one,methanesulfonate
Packaging: 1mg
Price: $141
Updated: 2021/12/16

More

Less

ZLJ-6 Chemical Properties,Usage,Production

Description

ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC₅₀ = 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective COX inhibitors.

in vitro

zlj-6 was identified as a potent inhibitor of cyclooxygenase in human whole blood. it also inhibited the production of thromboxane b(2) and prostaglandin e(2) in calcium ionophore a23187-induced human and rat whole blood, and rat peritoneal leukocytes. zlj-6 suppressed the activity of 5-lipoxygenase in the rat basophilic leukemia (rbl-1) cell lysate and in intact cells and reduced the generation of leukotriene b(4) (ltb(4)) in a23187-stimulated human or rat whole blood, and rat peritoneal leukocytes [1].

in vivo

orally administered zlj-6 demonstrated potent anti-inflammatory activity in the carrageenin-induced paw oedema model in rats and showed analgesic activity in the acetic acid-induced abdominal construction model in mice. no gastrointestinal ulcers were found with the anti-inflammatory dose (30 mg/kg) in normal rats [1].

IC 50

0.73, 0.31, and 0.99 μm for cox-1, cox-2, and 5-lo, respectively

References

[1] li, l. ,ji, h.,sheng, l., et al. the anti-inflammatory effects of zlj-6, a novel dual cyclooxygenase/5-lipoxygenase inhibitor. european journal of pharmacology 607 (1-3), 244-250 (2009).

ZLJ-6 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ZLJ-6 Suppliers

China 22 United States 3 Global 25

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49734
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

1051931-39-5, ZLJ-6Related Search:

4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid ZL0580 5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ZL0420

ZLJ-6

ZLJ-6 Exclusive

QEJPXTVPNIOEHZ-VEZAGKLZSA-N

1051931-39-5

C12H13N3O3SCH3SO3H