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Alpelisib (BYL719)

Product Name
Alpelisib (BYL719)
CAS No.
1217486-61-7
Chemical Name
Alpelisib (BYL719)
Synonyms
Alpelisib;Piqray;BYL-719;100803;CS-614;BLV-719;BYL-719 /BYL719;Alpelisib (BYL719);BYL-719(Alpelisib);Alpelisib (BLY-719
CBNumber
CB52604234
Molecular Formula
C19H22F3N5O2S
Formula Weight
441.47
MOL File
1217486-61-7.mol
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Alpelisib (BYL719) Property

Density 
1.391
storage temp. 
Store at -20°C
solubility 
≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
White solid.
pka
6.29±0.70(Predicted)
color 
Off-white to light yellow
InChIKey
STUWGJZDJHPWGZ-LBPRGKRZSA-N
SMILES
N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
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Safety

HS Code 
29341000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16986
Product name
BYL719
Purity
≥98%
Packaging
5mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
16986
Product name
BYL719
Purity
≥98%
Packaging
10mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
16986
Product name
BYL719
Purity
≥98%
Packaging
25mg
Price
$207
Updated
2024/03/01
TRC
Product number
M331055
Product name
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
Packaging
25mg
Price
$190
Updated
2021/12/16
ApexBio Technology
Product number
A8346
Product name
BYL-719
Packaging
20mg
Price
$200
Updated
2021/12/16
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Alpelisib (BYL719) Chemical Properties,Usage,Production

Description

BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.

Uses

(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor for the treatment of proliferative diseases.

Definition

ChEBI: (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.

brand name

Piqray

General Description

Class: lipid kinase; Treatment: breast cancer; Other name: NVP-BYL719; Elimination half-life = 13.7 h; Protein binding = 89%

target

PI3Kα

References

1. furet p, guagnano v, fairhurst ra et al. discovery of nvp-byl719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. bioorg med chem lett 2013; 23: 3741-3748. 2. azab f, vali s, abraham j et al. pi3kca plays a major role in multiple myeloma and its inhibition with byl719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance. br j haematol 2014; 165: 89-101. 3. juric d, argiles g, burris h et al. phase i study of byl719, an alpha-specific pi3k inhibitor, in patients with pik3ca mutant advanced solid tumors: preliminary efficacy and safety in patients with pik3ca mutant er-positive (er+) metastatic breast cancer (mbc). cancer res 2012; 72: p6-10.

Alpelisib (BYL719) Preparation Products And Raw materials

Raw materials

Preparation Products

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Alpelisib (BYL719) Suppliers

Canada 1 China 203 India 6 United States 20 Global 230
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from Alpelisib (BYL719) manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Alpelisib 1217486-61-7
Price
US $0.00/G
Min. Order
1G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-08
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Alpelisib. 1217486-61-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2025-01-14
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Alpelisib 1217486-61-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
50kg/Month
Release date
2024-06-28

1217486-61-7, Alpelisib (BYL719)Related Search:

D-ERYTHRO-SPHINGOSINE BKM120 (NVP-BKM120, Buparlisib) MK-2206 2HCl CAL-101 Trametinib 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]- BEZ235 (NVP-BEZ235, Dactolisib) KU-55933 Selumetinib BML-275 PLX-4720 CX-4945 Fluoxetine hydrochloride Tubastatin A hydrochloride N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide hydrochloride BI 2536 Neratinib Glucagon Receptor Antagonist I

  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719
  • BYL-719 /BYL719
  • Alpelisib
  • BLV-719
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-Methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxaMide
  • ALPELISIB;BYL-719; BYL 719
  • CS-614
  • Alpelisib - NVP-BYL719 | BYL-719
  • 100803
  • (2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide
  • 1,2-Pyrrolidinedicarboxamide, N1-[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-, (2S)-
  • Alpelisib (BYL719)
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide BYL-719
  • BYL-719 (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
  • BYL-719(Alpelisib)
  • (S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)-pyridin-4-yl)thiazol-2-yl)pyrrolid
  • Alpelisib, 98%, a potent and selective PI3Kα inhibitor
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide ISO 9001：2015 REACH
  • Alpelisib (BLY-719
  • Piqray
  • (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidine
  • Inhibitor,Phosphoinositide 3-kinase,PI3K,Alpelisib,inhibit,phosphorylation,p110α,cancer,BYL 719,antineoplastic,AKT,metastasis,mutant,BYL719,PIK3CA,breast
  • (2S) - N1- [4-methyl-5- [2- (2,2,2-trifluoro-1,1-dimethylethyl) -4-pyridyl] -2-thiazolyl] -1,2-pyrrolidine dicarboxylamide
  • Biopterin Impurity 2
  • Alpelisib, 10 mM in DMSO
  • 1217486-61-7
  • C19H22F3N5O2S
  • Inhibitors
  • Akt
  • mTOR
  • PI3K
  • Api
  • PI3K/Akt/mTOR
  • API