Alpelisib (BYL719)
- Product Name
- Alpelisib (BYL719)
- CAS No.
- 1217486-61-7
- Chemical Name
- Alpelisib (BYL719)
- Synonyms
- Alpelisib;Piqray;BYL-719;100803;CS-614;BLV-719;BYL-719 /BYL719;Alpelisib (BYL719);BYL-719(Alpelisib);Alpelisib (BLY-719
- CBNumber
- CB52604234
- Molecular Formula
- C19H22F3N5O2S
- Formula Weight
- 441.47
- MOL File
- 1217486-61-7.mol
Alpelisib (BYL719) Property
- Density
- 1.391
- storage temp.
- Store at -20°C
- solubility
- ≥22.07 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- White solid.
- pka
- 6.29±0.70(Predicted)
- InChIKey
- STUWGJZDJHPWGZ-LBPRGKRZSA-N
- SMILES
- N1(C(NC2=NC(C)=C(C3C=CN=C(C(C)(C)C(F)(F)F)C=3)S2)=O)CCC[C@H]1C(N)=O
Safety
- HS Code
- 29341000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16986
- Product name
- BYL719
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $54
- Updated
- 2024/03/01
- Product number
- 16986
- Product name
- BYL719
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $98
- Updated
- 2024/03/01
- Product number
- 16986
- Product name
- BYL719
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $207
- Updated
- 2024/03/01
- Product number
- M331055
- Product name
- (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide
- Packaging
- 25mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- A8346
- Product name
- BYL-719
- Packaging
- 20mg
- Price
- $200
- Updated
- 2021/12/16
Alpelisib (BYL719) Chemical Properties,Usage,Production
Description
BYL719 is an inhibitor of phosphoinositide 3-kinase α (PI3Kα; IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively). It is selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all). BYL719 (12.5, 25, and 50 mg/kg) reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model. It also reduces tumor burden in THP-1 acute myeloid leukemia (AML) and MCF-7 breast cancer mouse xenograft models. Formulations containing BYL719 have been used in the treatment of advanced or metastatic breast cancer.
Uses
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibitor for the treatment of proliferative diseases.
Uses
(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide is a newly developed phosphatidylinositol-3-kinase (PI3K) inhibitor and a mTOR inhibit or for the treatment of proliferative diseases.
Definition
ChEBI: (2S)-N1-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)-4-pyridinyl]-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.
target
PI3Kα
References
1. furet p, guagnano v, fairhurst ra et al. discovery of nvp-byl719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. bioorg med chem lett 2013; 23: 3741-3748. 2. azab f, vali s, abraham j et al. pi3kca plays a major role in multiple myeloma and its inhibition with byl719 decreases proliferation, synergizes with other therapies and overcomes stroma-induced resistance. br j haematol 2014; 165: 89-101. 3. juric d, argiles g, burris h et al. phase i study of byl719, an alpha-specific pi3k inhibitor, in patients with pik3ca mutant advanced solid tumors: preliminary efficacy and safety in patients with pik3ca mutant er-positive (er+) metastatic breast cancer (mbc). cancer res 2012; 72: p6-10.
Alpelisib (BYL719) Preparation Products And Raw materials
Raw materials
Preparation Products
Alpelisib (BYL719) Suppliers
View Lastest Price from Alpelisib (BYL719) manufacturers
- Product
- (2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide 1217486-61-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- Alpelisib (BYL719) 1217486-61-7
- Price
- US $50.00-500.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-30
- Product
- Alpelisib 1217486-61-7
- Price
- US $0.00/G
- Min. Order
- 1G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-08