ChemicalBook > CAS DataBase List > BrettPhosPalladacycle

BrettPhosPalladacycle

Reaction

Product Name: BrettPhosPalladacycle
CAS No.: 1148148-01-9
Chemical Name: BrettPhosPalladacycle
Synonyms: BrettPhos Pd G1;BrettPhos precatalyst;BrettPhos Palladacycle;BrettPhos Pd G1 Methyl-t-Butyl Ether Adduct;BrettPhos Pd G1 MTBE adduct;BrettPhos Palladacycle Gen. 1;chloro-(2-phenylethylamino)palladium;[2-(2-aminoethyl)phenyl]palladium(1+);(II) Chloro[2-(dicyclohexylphosphino)-3;(BrettPhos) palladium(II) phenethylamine chloride
CBNumber: CB52614378
Molecular Formula: C43H63ClNO2PPd
Formula Weight: 798.83
MOL File: 1148148-01-9.mol

Less

BrettPhosPalladacycle Property

Melting point:: 198-204 °C
storage temp.: 2-8°C, protect from light, stored under nitrogen
form: Powder
color: white

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 718750
Product name: BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity: may contain up to 1 mole equivalent of MTBE, 97%
Packaging: 100 mg
Price: $71.81
Updated: 2025/07/31

Sigma-Aldrich

Product number: 718750
Product name: BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity: may contain up to 1 mole equivalent of MTBE, 97%
Packaging: 1 g
Price: $384.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 718750
Product name: BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity: may contain up to 1 mole equivalent of MTBE, 97%
Packaging: 5 g
Price: $1490
Updated: 2025/07/31

Sigma-Aldrich

Product number: 718750
Product name: BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity: may contain up to 1 mole equivalent of MTBE, 97%
Packaging: 1g
Price: $533
Updated: 2024/03/01

Sigma-Aldrich

Product number: 718750
Product name: BrettPhos Pd G1, Methyl t-Butyl Ether Adduct
Purity: may contain up to 1 mole equivalent of MTBE, 97%
Packaging: 5g
Price: $1450
Updated: 2024/03/01

Less

BrettPhosPalladacycle Chemical Properties,Usage,Production

Reaction

Catalyst for cross-coupling reactions using aryl mesylates with electron-deficient anilines.
Catalyst for rapid C-N bond-forming processes at low catalyst loading.
Cross-coupling of 3-Bromo-2-aminopyridine with primary amines.

Uses

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst for:

C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
Amination reaction
N-arylation of aminophenols

General Description

BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to ?40 °C, and can be used in a variety of cross-coupling protocols.

reaction suitability

core: palladium
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst
reaction type: Cross Couplings

BrettPhosPalladacycle Preparation Products And Raw materials

Raw materials

Preparation Products

Less

BrettPhosPalladacycle Suppliers

China 89 India 1 United States 7 Global 97

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjin Cynthia chemicals Technology Co.,Ltd

Tel: 0550-5618439 15951861180
Fax: 0550-5610690
Email: cynthiachem@163.com
Country: China
ProdList: 291
Advantage: 62

WuHan Taiyukaishang Chemical Co., Ltd.

Tel: 027-027-87680032 18963957250
Email: taiyuchem@163.com
Country: China
ProdList: 180
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Shanghai Incat Chemtech Co.,Ltd.

Tel: 021-57603038 13601791340
Fax: 021-57603057
Email: 307593986@qq.com
Country: China
ProdList: 475
Advantage: 58

Sinocompound Catalysts Co., Ltd.

Tel: 0512-67216630 67216634
Fax: 0512-56316689
Email: sales@sinocompound.com
Country: China
ProdList: 271
Advantage: 64

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9279
Advantage: 55

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd.

Tel: 0371-65511006 18625597674
Email: sales@kingorgchem.com
Country: China
ProdList: 976
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

LaaJoo

Tel: 021-60702684 18516024827
Email: huang.jiayi@sinocompound.com
Country: China
ProdList: 2280
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

LinkChem Technology Co., Ltd.

Tel: 021-58950110 13124863828
Fax: 021-20922272
Email: sales@linkchem.cn
Country: China
ProdList: 2998
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 8596
Advantage: 58

XinYao(Shenzhen) Biological Technology Co., Ltd.

Tel: 0755-89880280
Fax: 0755-89880280
Email: 3004662104@qq.com
Country: China
ProdList: 1829
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 10083
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55055611 18137792234
Fax: QQ：3002694073
Email: 3002694073@qq.com
Country: China
ProdList: 9987
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 8460
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Zhuoer Chemical Co., Ltd

Tel: 02120970332; +8613524231522
Fax: +86-21-58816016
Email: sales@zhuoerchem.com
Country: China
ProdList: 2904
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

Wuhan LPBchem Technology Co.,Ltd

Tel: +86-027-63498399 15071314134
Fax: +86-027-63499599
Email: LPBchem@163.com
Country: CHINA
ProdList: 57
Advantage: 58

HUNAN CHEMFISH SCIENTIFIC CO.,LTD

Tel: +86-0731-85567275 13298656710
Fax: QQ:3554193828
Email: sales05@chemfish.com
Country: China
ProdList: 7448
Advantage: 58

Shanghai TenSus Biotechnology Co., Ltd.

Tel: 021-50895067 18616507272
Fax: 021-50895067
Email: tensus@163.com
Country: China
ProdList: 8073
Advantage: 58

Wu Han Lbpchem Chemical Co., Ltd.

Tel: 02763499399 13797220777
Email: lpbchem@163.com
Country: China
ProdList: 99
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 5999
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-81138252 +86-173 9270 1263
Fax: 029-88380327
Email: 1057@dideu.com
Country: China
ProdList: 3999
Advantage: 58

Shanghai Moheng Technology Co., Ltd.

Tel: 15001930925
Email: sales@mohengsci.com
Country: CHINA
ProdList: 424
Advantage: 58

Richest Group Ltd

Tel: 18017061086
Email: oled@richest-group.com
Country: CHINA
ProdList: 5600
Advantage: 58

QINGDAO KAIENSI INTERNATIONAL TRADE CO.,LTD.

Tel: +86-0532-8699-9256 +8615254267723
Fax: 0532-86999256
Email: kaley@cnfdevelop.com
Country: China
ProdList: 1410
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

wuhan zitai technology co.,ltd.

Tel: 13995588728
Email: 303957778@qq.com
Country: China
ProdList: 224
Advantage: 58

Qicai Lanxin (Beijing) Science Co., Ltd.

Tel: 010-65771068 15510023055
Email: qicailanxin@163.com
Country: China
ProdList: 48
Advantage: 58

xinxiang runyu material co.,Ltd

Tel: 15690792173
Fax: 0373-7759608
Email: sales@runvmat.com
Country: China
ProdList: 265
Advantage: 58

Shanghai Botuo Biotechnology Co., LTD

Tel: 16621358918
Fax: QQ:402135374
Email: botuopharma888@163.com
Country: China
ProdList: 9208
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

Less

View Lastest Price from BrettPhosPalladacycle manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: BrettPhosPalladacycle 1148148-01-9
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-13

Shaanxi Dideu Medichem Co. Ltd

Product: Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II) 1148148-01-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-04-21

Wuhan LPBchem Technology Co.,Ltd

Product: Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) /BrettPhos Pd G1 1148148-01-9
Price: US $10.00-10.00/g
Min. Order: 1g
Purity: 0.98
Supply Ability: 50kg
Release date: 2020-09-27

1148148-01-9, BrettPhosPalladacycleRelated Search:

Chloro(2-dicyclohexylphosphino-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-aMino-1,1'-biphenyl-2-yl)palladiuM(II), Min. 98% [BrettPhos Palladacycle] XPhos Pd G3 SPhos Palladacycle Gen. 4 XPhos Pd G4 Xantphos Pd G3 BrettPhos Pd G3 XPhos Pd G2 RuPhos Pd G1 Methyl t--Butyl Ether Adduct SPhos Pd G2 Palladacycle Gen. 3 t-BuXphos Palladacycle Gen. 4 RuPhos Palladacycle Gen. 4 t-BuBrettPhos Palladacycle Gen. 3 SPhos Pd G3 SPhos Pd G1, Methyl t-Butyl Ether Adduct RuPhos Pd G2 tBuXPhos Pd G1 XPhos Pd G1

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-triisopropyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)

Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II),98%

BrettPhos Pd G1 Methyl-t-Butyl Ether Adduct

Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II), Min. 98% [BrettPhos Palladacycle]

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-aminoeth

Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-Minoethyl)phenyl]palladiuM(II),Min.98%[BrettPhosPalladacycle]

(BrettPhos) palladium(II) phenethylamine chloride

BrettPhos Palladacycle

BrettPhos precatalyst

Dicyclohexyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine-(2-(2-aminoethyl)phenyl)palladium(II) chloride

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(ii)

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl][2-(2-amino

CHLORO[2-(DICYCLOHEXYLPHOSPHINO)-3,6-DIMETHOXY-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL][2-(2-AMINOETHYL)PHENYL]PALLADIUM(II),MIN.98%[BRETTPHOSPALLADACYCLEGEN.1]

(SP-4-4)-[2-[2-(Amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine-κP]palladium

Chloro[2-(dicyclohexylphosphino)-3,6-diMethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl][2-(2-aMinoethyl)phenyl]palladiuM(II) [BrettPhos Palladacycle]

[2-(2-aminoethyl)phenyl]palladium(1+)

dicyclohexyl-[3,6-dimethoxy-2-(2,4,6-triisopropylphenyl)phenyl]phosphane

BrettPhos Palladacycle Gen. 1

Chloride (2-dicyclohexylphosphino-3,6-dimethoxy-2 ', 4', 6 '- triisopropyl-1,1' - biphenyl) [2 - (2-aminoethyl phenyl)] palladium (II)

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / BrettPhos Pd G1

Palladium, [2-[2-(amino-κN)ethyl]phenyl-κC]chloro[dicyclohexyl[3,6-dimethoxy-2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine-κP]-, (SP-4-4)-

BrettPhos Pd G1

Chloro[2-(dicyclohexylphosphino)-2',4',6'-triisopropyl-3,6-dimethoxybiphenyl][2-(2-aminoethyl)phenyl]palladium(II)

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-...

BrettPhos Pd G1 / Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)

chloro-(2-phenylethylamino)palladium

Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)

BrettPhos Pd G1 MTBE adduct

Chloro[2-(dicyclohexylphosphino)-2’,4’,6’-triisopropyl-3,6-dimethoxybiphenyl][2-(2-aminoethyl)phenyl]palladium(II)

(II) Chloro[2-(dicyclohexylphosphino)-3

(2-Dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-triisopropyl-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II)chloride,BrettPhosPalladacycleGen.1

BrettPhos Palladacycle Gen. 1 Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)

1148148-01-9

C43H63ClNO2PPd

C48H74ClNO3PPd

Buchwald Ligands&Precatalysts

Buchwald Precatalysts Series