XPhos Pd G4

Product Name: XPhos Pd G4
CAS No.: 1599466-81-5
Chemical Name: XPhos Pd G4
Synonyms: XPhos Pd G4;XPhosPalladacycleG4;XPhos Pd G4 ChemBeads;Xphos Palladacycle Gen.4;Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-...;(2dicyclohexylphosphino2′,4′,6′triisopropyl1,1′biphenyl)[2(2′methylamino1,1′biphenyl)]palladium(II) methanesulfonate;Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II);methanesulfonylacid(2-dicyclohexylphosphinoyl-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-methylamineyl-1,1'-biphenyl-2-yl)paladium(I-I);XPhos Pd G4 / Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II);Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (XPhos Pd G4)
CBNumber: CB63139770
Molecular Formula: C47H64NO3PPdS
Formula Weight: 860.49
MOL File: 1599466-81-5.mol

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XPhos Pd G4 Property

Melting point:: 150 °C
storage temp.: 2-8°C, protect from light, stored under nitrogen
form: Powder
color: white to off-white
InChI: InChI=1S/C33H49P.C13H11N.CH4O3S.Pd/c1-23(2)26-21-30(24(3)4)33(31(22-26)25(5)6)29-19-13-14-20-32(29)34(27-15-9-7-10-16-27)28-17-11-8-12-18-28;1-14-13-10-6-5-9-12(13)11-7-3-2-4-8-11;1-5(2,3)4;/h13-14,19-25,27-28H,7-12,15-18H2,1-6H3;2-7,9-10H,1H3;1H3,(H,2,3,4);/q;-2;;+2
InChIKey: RWNNUNWRORBXQJ-UHFFFAOYSA-N
SMILES: P(C1CCCCC1)(C1CCCCC1)(C1C=CC=CC=1C1C(=CC(C(C)C)=CC=1C(C)C)C(C)C)[Pd+2]1(N(C2=CC=CC=C2C2=CC=CC=[C-]12)C)[O-]S(=O)(=O)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 804274
Product name: XPhos Pd G4
Purity: 95%
Packaging: 250mg
Price: $72
Updated: 2025/07/31

Sigma-Aldrich

Product number: 804274
Product name: XPhos Pd G4
Purity: 95%
Packaging: 1g
Price: $212
Updated: 2025/07/31

Sigma-Aldrich

Product number: 804274
Product name: XPhos Pd G4
Purity: 95%
Packaging: 1 unit
Price: $679.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 804274
Product name: XPhos Pd G4
Purity: 95%
Packaging: 1 unit
Price: $679.4
Updated: 2025/07/31

Strem Chemicals

Product number: 46-0327
Product name: Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II), min. 98% [XPhos Palladacycle Gen. 4]
Packaging: 250mg
Price: $71
Updated: 2024/03/01

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XPhos Pd G4 Chemical Properties,Usage,Production

Chemical Properties

Powder. Bench stable, soluble in most organic solvents.

Uses

XPhos Pd G4 is a powerful ligand for classic cross-coupling reactions combined with the Buchwald Fourth Generation Palladacycle.

Reactions

Palladium catalyst used in the Suzuki-Miyaura coupling of unstable boronic acids.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Cross Couplings
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: catalyst

Synthesis

A dry round-bottomed flask (25 mL) was equipped with a stirring bar and then palladium dimer methanesulfonate (1 mmol) and XPhos (0.953 g) were added to the reaction flask under nitrogen atmosphere. Dry dichloromethane was added to the above reaction mixture as reaction solvent (10 mL) and the mixture was stirred at room temperature for 16 hours. At the end of the reaction the resulting reaction mixture was concentrated under vacuum making the total volume of the mixture about 1-2 mL. To the above reaction mixture n-pentane (20 mL) was added to precipitate a black solid and the mixture was filtered. The resulting filtrate was concentrated in vacuo to afford XPhos Pd G4, (SP-4-3)-[dicyclohexyl[2',4',6'-tris(isopropyl)[1,1'-biphenyl]-2-yl]phosphine](methanesulfonic acid)[2'-(methylamino)[1,1'-biphenyl]-2-yl]palladium.

XPhos Pd G4 Preparation Products And Raw materials

Raw materials

Preparation Products

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XPhos Pd G4 Suppliers

China 110 United States 5 Global 115

Wu Han Lbpchem Chemical Co., Ltd.

Tel: 02763499399 13797220777
Email: lpbchem@163.com
Country: China
ProdList: 99
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16676
Advantage: 50

Zhengzhou Kingorgchem Chemical Technology Co., Ltd.gy Co., Ltd.

Tel: 0371-65511006 18625597674
Email: sales@kingorgchem.com
Country: China
ProdList: 849
Advantage: 55

Wuhan Jiade Ruifeng New Materials Co., Ltd

Tel: 18271874579 / 18971104330 18971104330
Email: Xiaowei@JDchem.com.cn
Country: China
ProdList: 268
Advantage: 58

BeiJing Greenchem Technology Co.,Ltd.

Tel: 131-21959385 18804271668
Fax: 010-62925455
Email: chemrocking@bjgreenchem.com
Country: China
ProdList: 273
Advantage: 58

Sinocompound Catalysts Co., Ltd.

Tel: 0512-67216630 67216634
Fax: 0512-56316689
Email: sales@sinocompound.com
Country: China
ProdList: 263
Advantage: 64

Wuhan Houshuang Technology Co., Ltd

Tel: 13080686708; 13080686708
Email: houshuangchem@163.com
Country: China
ProdList: 78
Advantage: 58

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9411
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44802
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11032
Advantage: 64

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View Lastest Price from XPhos Pd G4 manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) 1599466-81-5
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: XPhos Pd G4 1599466-81-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-09

Shaanxi Dideu Medichem Co. Ltd

Product: Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) 1599466-81-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-04-21

1599466-81-5, XPhos Pd G4Related Search:

Methanesulfonato(triphenylphosphine)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) (PPH3 PD G3) XPhos Pd G3 SPhos Palladacycle Gen. 4 Xantphos Pd G3 BrettPhos Pd G3 XPhos Pd G2 RuPhos Pd G1 Methyl t--Butyl Ether Adduct SPhos Pd G2 BrettPhosPalladacycle Palladacycle Gen. 3 t-BuXphos Palladacycle Gen. 4 t-BuBrettPhos Palladacycle Gen. 3 SPhos Pd G3 SPhos Pd G1, Methyl t-Butyl Ether Adduct RuPhos Pd G2 tBuXPhos Pd G1 XPhos Pd G1 RuPhos Palladacycle Gen. 4

(SP-4-3)-[Dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine](methanesulfonato)[2'-(methylamino)[1,1'-biphenyl]-2-yl]palladium

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),[XPhos Palladacycle Gen. 4]

Xphos Palladacycle Gen.4

METHANESULFONATO(2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL)(2'-METHYLAMINO-1,1'-BIPHENYL-2-YL)PALLADIUM(II),MIN.98%[XPHOSPALLADACYCLEGEN.4]

(2dicyclohexylphosphino2′,4′,6′triisopropyl1,1′biphenyl)[2(2′methylamino1,1′biphenyl)]palladium(II) methanesulfonate

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) / XPhos Pd G4

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-...

XPhosPalladacycleG4

XPhos Pd G4 / Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II)

XPhos Pd G4

Methanesulfonato(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) (XPhos Pd G4)

XPhos Pd G4 ChemBeads

Methanesulfonicacid(2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II),[XPhosPalladacycleGen.4]

methanesulfonylacid(2-dicyclohexylphosphinoyl-2',4',6'-tri-isopropyl-1,1'-biphenyl)(2'-methylamineyl-1,1'-biphenyl-2-yl)paladium(I-I)

1599466-81-5

C47H64NO3PPdS

Buchwald Ligands&Precatalysts

Buchwald Precatalysts Series

Pd