CEP 33779

ChemicalBook > CAS DataBase List > CEP 33779

Product Name: CEP 33779
CAS No.: 1257704-57-6
Chemical Name: CEP 33779
Synonyms: CS-1066;CEP33779 CEP-33779;CEP 33779 USP/EP/BP;CEP-33779, 10 mM in DMSO;CEP33779; CEP-33779; CEP 33779.;Inhibitor,inhibit,JAK,CEP 33779,Janus kinase,CEP-33779;N-(3-(4-Methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridi;N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;[8-(4-Methylsulfonylphenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl][3-(4-methylpiperazin-1-yl)phenyl]amine;N-[3-(4-Methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
CBNumber: CB52627680
Molecular Formula: C24H26N6O2S
Formula Weight: 462.57
MOL File: 1257704-57-6.mol

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CEP 33779 Property

Density: 1.35
storage temp.: Store at -20°C
solubility: ≥23.15 mg/mL in DMSO with gentle warming; insoluble in EtOH
form: solid
pka: 7.78±0.42(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 16732
Product name: CEP-33779
Purity: ≥95%
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16732
Product name: CEP-33779
Purity: ≥95%
Packaging: 1mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 16732
Product name: CEP-33779
Purity: ≥95%
Packaging: 5mg
Price: $281
Updated: 2024/03/01

TRC

Product number: C256680
Product name: CEP-33779
Packaging: 500μg
Price: $55
Updated: 2021/12/16

ChemScene

Product number: CS-3439
Product name: CEP-33779
Purity: 99.36%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

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CEP 33779 Chemical Properties,Usage,Production

Description

Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC₅₀ = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models of systemic lupus erythematosus, CEP-33779 reduces the production of inflammatory cytokines, decreases splenomegaly and lymphomegaly, and extends survival. It also diminishes inflammatory signaling and improves clinical scores in mice during collagen antibody-induced arthritis and collagen type II-induced arthritis. CEP-33779 induces regression of established colorectal tumors in mice, reducing angiogenesis and proliferation of tumor cells.

Uses

CEP-33779 acts as an orally available inhibitor of JAK2 reducing the production of inflammatory cytokines and decreasing splenomegaly. Anti-arthritic agent. Anticancer agent.

target

JAK2

CEP 33779 Preparation Products And Raw materials

Raw materials

Preparation Products

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CEP 33779 Suppliers

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View Lastest Price from CEP 33779 manufacturers

Career Henan Chemical Co

Product: CEP 33779 1257704-57-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-24

1257704-57-6, CEP 33779Related Search:

AZD 1480 Y27632 (hydrochloride) xav-939 LY 2784544 R406 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile

{[8-(4-methanesulfonyl-phenyl)-[1,2,4]triazolo[1,5-a]-pyridin-2-yl]-[3-(4-methyl-piperazin-1-yl)-phenyl]-amine}

CEP33779; CEP-33779; CEP 33779.

CS-1066

[8-(4-Methylsulfonylphenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl][3-(4-methylpiperazin-1-yl)phenyl]amine

N-[3-(4-Methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine

[1,2,4]Triazolo[1,5-a]pyridin-2-amine, N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-

N-(3-(4-Methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridi

N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine

CEP 33779 USP/EP/BP

CEP33779 CEP-33779

Inhibitor,inhibit,JAK,CEP 33779,Janus kinase,CEP-33779

CEP-33779, 10 mM in DMSO

1257704-57-6

Inhibitors

JAK

STAT

Inhibitor

JAK/STAT