CEP 33779
- Product Name
- CEP 33779
- CAS No.
- 1257704-57-6
- Chemical Name
- CEP 33779
- Synonyms
- CS-1066;CEP33779 CEP-33779;CEP 33779 USP/EP/BP;CEP-33779, 10 mM in DMSO;CEP33779; CEP-33779; CEP 33779.;Inhibitor,inhibit,JAK,CEP 33779,Janus kinase,CEP-33779;N-(3-(4-Methylpiperazin-1-yl)phenyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridi;N-[3-(4-methylpiperazin-1-yl)phenyl]-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine;[8-(4-Methylsulfonylphenyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl][3-(4-methylpiperazin-1-yl)phenyl]amine;N-[3-(4-Methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-amine
- CBNumber
- CB52627680
- Molecular Formula
- C24H26N6O2S
- Formula Weight
- 462.57
- MOL File
- 1257704-57-6.mol
CEP 33779 Property
- Density
- 1.35
- storage temp.
- Store at -20°C
- solubility
- ≥23.15 mg/mL in DMSO with gentle warming; insoluble in EtOH
- form
- solid
- pka
- 7.78±0.42(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 16732
- Product name
- CEP-33779
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 16732
- Product name
- CEP-33779
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16732
- Product name
- CEP-33779
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $281
- Updated
- 2024/03/01
- Product number
- C256680
- Product name
- CEP-33779
- Packaging
- 500μg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- CS-3439
- Product name
- CEP-33779
- Purity
- 99.36%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
CEP 33779 Chemical Properties,Usage,Production
Description
Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription family. CEP-33779 is a potent, orally available inhibitor of JAK2 (IC50 = 1.3 nM). It shows 65-fold selectivity for JAK2 over JAK3. In mouse models of systemic lupus erythematosus, CEP-33779 reduces the production of inflammatory cytokines, decreases splenomegaly and lymphomegaly, and extends survival. It also diminishes inflammatory signaling and improves clinical scores in mice during collagen antibody-induced arthritis and collagen type II-induced arthritis. CEP-33779 induces regression of established colorectal tumors in mice, reducing angiogenesis and proliferation of tumor cells.
Uses
CEP-33779 acts as an orally available inhibitor of JAK2 reducing the production of inflammatory cytokines and decreasing splenomegaly. Anti-arthritic agent. Anticancer agent.
target
JAK2
CEP 33779 Preparation Products And Raw materials
Raw materials
Preparation Products
CEP 33779 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from CEP 33779 manufacturers
- Product
- CEP 33779 1257704-57-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-24