Description References
ChemicalBook > CAS DataBase List > GSK 189254A

GSK 189254A

Description References
Product Name
GSK 189254A
CAS No.
720690-73-3
Chemical Name
GSK 189254A
Synonyms
CS-2905;GSK 189254A;histamine H3 receptor antagonist GS189254A;Histamine Receptor,GSK-189254,GSK 189254,GSK-189254A,inhibit,GSK189254A,Inhibitor;6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-MethylnicotinaMide;N-(4-METHOXYBENZYL)-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDIN-4-AMINE;6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide;3-Pyridinecarboxamide, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-
CBNumber
CB52627923
Molecular Formula
C21H25N3O2
Formula Weight
351.44
MOL File
720690-73-3.mol
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GSK 189254A Property

Boiling point:
545.0±50.0 °C(Predicted)
Density 
1.195±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:25.0(Max Conc. mg/mL);71.13(Max Conc. mM)
form 
A solid
pka
14.26±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-6206
Product name
GSK189254A
Purity
98.45%
Packaging
1mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-6206
Product name
GSK189254A
Purity
98.45%
Packaging
5mg
Price
$100
Updated
2021/12/16
ChemScene
Product number
CS-6206
Product name
GSK189254A
Purity
98.45%
Packaging
10mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-6206
Product name
GSK189254A
Purity
98.45%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-6206
Product name
GSK189254A
Purity
98.45%
Packaging
100mg
Price
$650
Updated
2021/12/16
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GSK 189254A Chemical Properties,Usage,Production

Description

GSK189254A is a histamine H3 receptor antagonist for the treatment of narcolepsy.It may also be useful for the treatment of dementia and neuropathic pain. Its pharmacological effect may be related to its effect on increasing the release neurotransmitter in the brain. Microdialysis studies demonstrated that GSK189254 increased the release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK189254 significantly improved performance of rats in diverse cognition paradigms, including passive avoidance, water maze, object recognition, and attentional set shift. These data suggest that GSK189254 may have therapeutic potential for the symptomatic treatment of dementia in Alzheimer's disease and other cognitive disorders.

References

Medhurst, Andrew D., and A. I. J. Beresford. "GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models." Alzheimers & Dementia 321.3(2007):1032.
Plisson, Christophe, et al. "PET imaging of the CNS histamine H3 receptor using [11C] GSK189254A." Neuroimage 31.1(2006):T47-T47.
http://medkoo.com/products/10117

GSK 189254A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK 189254A Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4456
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
1008
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8014
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2982
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
6527
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
7539
Advantage
58

720690-73-3, GSK 189254ARelated Search:


  • GSK 189254A
  • 6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yloxy)-N-MethylnicotinaMide
  • N-(4-METHOXYBENZYL)-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B<WBR />]PYRIDIN-4-AMINE
  • 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylpyridine-3-carboxamide
  • histamine H3 receptor antagonist GS189254A
  • CS-2905
  • 3-Pyridinecarboxamide, 6-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-
  • Histamine Receptor,GSK-189254,GSK 189254,GSK-189254A,inhibit,GSK189254A,Inhibitor
  • 720690-73-3